DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and LRRC4

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_071426.1	Gene:	LRRC4 / 64101	HGNCID:	15586	Length:	653	Species:	Homo sapiens

Alignment Length:	646	Identity:	134/646 - (20%)
Similarity:	231/646 - (35%)	Gaps:	151/646 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYL 84
            |||...:| ..|.....:|.|.|:|  :|.....:|:...|:.:|..:.:..:.|.|.:|:|..:
Human    29 WILCAAIA-AAASAGPQNCPSVCSC--SNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMI 90

  Fly    85 NREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILY 149
            ..:.|..|.  :|:.:.|.::.::.|...:|..|..|..::|.||.|.::....|....:||.|:
Human    91 QADTFRHLH--HLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELW 153

  Fly   150 LNGNPLKRLAAYQFPILPHLRTLDMHDC-LISYIDP------MSLANLNL--------------- 192
            |..||::.:.:|.|..:|.|..||:.:. .:.||..      .:|..|||
Human   154 LRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLV 218

  Fly   193 ----LEF---------------------------------------------LNLKNNLLESLSE 208
                ||.                                             |||.:|.|.||..
Human   219 GLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPH 283

  Fly   209 YVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSLV---CKGPPAQKDRTWDSVDDEL 270
            .:|..:..|..|.|..|||.|:|.: .:..|::...:.:.|..   |..|...:.|....||...
Human   284 DLFTPLRYLVELHLHHNPWNCDCDI-LWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQAS 347

  Fly   271 FGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESE-----SIA 330
            |.|.... |.:.....||..|......|..  .|:..|.|     :|.|..||..:.     |:.
Human   348 FQCSAPF-IMDAPRDLNISEGRMAELKCRT--PPMSSVKW-----LLPNGTVLSHASRHPRISVL 404

  Fly   331 SDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMGIF 395
            :|   ..|...:|...|.|.|.|..:|..|:  .|.|.||: :....|..:..:|
Human   405 ND---GTLNFSHVLLSDTGVYTCMVTNVAGN--SNASAYLN-VSTAELNTSNYSF---------- 453

  Fly   396 GTVFLLISISFVVCLCKRTTRQHRHANKAGVKSSVSFNDQEKKLLDSS---------VTTTTNDR 451
               |..:::.......:.|||:::...........::......|:.::         .|.||
Human   454 ---FTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTT--- 512

  Fly   452 GDSYGIDNQPTSIG-MNKGDSAGMG-FNQIEIHAVESHRHGSMLV----QQQPQQQQVAGGGGMR 510
                  |...||:. :.|.....:| |..:.:.|      .:||:    .::..||:........
Human   513 ------DKMQTSLDEVMKTTKIIIGCFVAVTLLA------AAMLIVFYKLRKRHQQRSTVTAART 565

  Fly   511 QQLMQVKDSTCGMMSVPTSMAGHAHSHPAQISEEFPLNVGVFPPPPEFCSNIVPNPAFGGN 571
            .:::||.:      .:|.:.:..|.:.|:.:|.|   ...|.|...:..:.....||.|.:
Human   566 VEIIQVDE------DIPAATSAAATAAPSGVSGE---GAVVLPTIHDHINYNTYKPAHGAH 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:290566	16/58 (28%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	14/48 (29%)
		leucine-rich repeat	145..168	CDD:275380	8/22 (36%)
		leucine-rich repeat	169..216	CDD:275380	19/117 (16%)
		LRRCT	225..274	CDD:214507	13/51 (25%)
		Ig	295..367	CDD:143165	19/76 (25%)
LRRC4	NP_071426.1	LRRNT	46..79	CDD:214470	8/34 (24%)
		LRR	<74..291	CDD:227223	45/218 (21%)
		LRR 1	76..97		5/20 (25%)
		leucine-rich repeat	77..100	CDD:275380	6/24 (25%)
		LRR 2	100..121		4/20 (20%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR 3	124..145		6/20 (30%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR 4	148..169		8/20 (40%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		LRR 5	172..194		5/21 (24%)
		leucine-rich repeat	173..197	CDD:275380	5/23 (22%)
		LRR 6	197..218		4/20 (20%)
		leucine-rich repeat	198..219	CDD:275380	4/20 (20%)
		LRR 7	219..240		2/20 (10%)
		leucine-rich repeat	220..243	CDD:275380	2/22 (9%)
		LRR 8	243..264		0/20 (0%)
		leucine-rich repeat	244..267	CDD:275380	0/22 (0%)
		LRR 9	267..288		8/20 (40%)
		leucine-rich repeat	268..289	CDD:275380	8/20 (40%)
		LRRCT	300..351	CDD:214507	13/51 (25%)
		IG	359..441	CDD:214652	25/94 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910