DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and LRFN1

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_065913.1	Gene:	LRFN1 / 57622	HGNCID:	29290	Length:	771	Species:	Homo sapiens

Alignment Length:	406	Identity:	93/406 - (22%)
Similarity:	152/406 - (37%)	Gaps:	79/406 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SRTPRTLPVCWILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVL 74
            |..|..||     ..|:.|..|.. ...|...|.|:......:.:|:...|..:|..:...:..|
Human    12 SPPPAALP-----FLLLLWAGASR-GQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVEL 70

  Fly    75 VLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTF 139
            .|.||.|..:.|.:|:  .:.:|..:.|.::.:..:...:|.:|:.|..:.|..|:|..:..|..
Human    71 RLTDNFIAAVRRRDFA--NMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQL 133

  Fly   140 MGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNL------------ 192
            .|...||.|.|..|.::|:.:..|            |..:|.::.:.|:..||
Human   134 RGLGNLRHLILGNNQIRRVESAAF------------DAFLSTVEDLDLSYNNLEALPWEAVGQMV 186

  Fly   193 -LEFLNLKNNLLESLSEYVFQHMANL--------------------------------KTLSLEE 224
             |..|.|.:||::.::|..|..:..|                                .|:|...
Human   187 NLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGG 251

  Fly   225 NPWQCNCKLRKFRGWYVNSRLSSVSLVCKGPPAQKDRTWDSVDDELFGC-PPRVEIFNNEEVQNI 288
            ||..|||:|...|.......|.:    |..|....||.:.|:.:|.|.| ||.:..........:
Human   252 NPLHCNCELLWLRRLTREDDLET----CATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVV 312

  Fly   289 DIGSNTTFSCLVYGDPLPEVAWEL-NGKILDNDNVLFESESIASDKLWSNLTVFNVTSLDAGTYA 352
            : |...:..|...|||.|.|.|.. :|::|.|.:    ...:..|   ..|.|...|..|:||:.
Human   313 E-GQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSS----RTRVRGD---GTLDVTITTLRDSGTFT 369

  Fly   353 CTGSNSIGSMTQNISI 368
            |..||:.|..|..:.:
Human   370 CIASNAAGEATAPVEV 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:290566	15/58 (26%)
		leucine-rich repeat	97..120	CDD:275380	4/22 (18%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	9/41 (22%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		leucine-rich repeat	169..216	CDD:275380	12/59 (20%)
		LRRCT	225..274	CDD:214507	16/49 (33%)
		Ig	295..367	CDD:143165	22/72 (31%)
LRFN1	NP_065913.1	LRR_RI	<65..174	CDD:238064	27/122 (22%)
		LRR_8	65..125	CDD:290566	14/61 (23%)
		LRR 1	66..87		7/22 (32%)
		leucine-rich repeat	67..90	CDD:275380	7/24 (29%)
		LRR 2	90..111		3/20 (15%)
		leucine-rich repeat	91..114	CDD:275380	4/22 (18%)
		LRR_8	113..174	CDD:290566	16/72 (22%)
		LRR 3	114..135		5/20 (25%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR 4	138..159		7/32 (22%)
		leucine-rich repeat	139..163	CDD:275380	8/35 (23%)
		LRR_8	162..222	CDD:290566	12/59 (20%)
		LRR 5	163..184		3/20 (15%)
		leucine-rich repeat	164..187	CDD:275380	3/22 (14%)
		LRR_4	165..203	CDD:289563	8/37 (22%)
		LRR 6	187..208		7/20 (35%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		LRR 7	211..232		1/20 (5%)
		leucine-rich repeat	212..230	CDD:275380	1/17 (6%)
		LRRCT	252..>284	CDD:214507	10/35 (29%)
		IG_like	310..385	CDD:214653	23/82 (28%)
		Ig	314..387	CDD:299845	23/79 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422
		fn3	426..500	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..743
		PDZ-binding	768..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960