DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and ISLR2

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001123608.1	Gene:	ISLR2 / 57611	HGNCID:	29286	Length:	745	Species:	Homo sapiens

Alignment Length:	587	Identity:	115/587 - (19%)
Similarity:	196/587 - (33%)	Gaps:	171/587 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 WTVADDWSL-----SCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNRE 87
            |.|   |:|     ||...|.|......:.|.|:..:|..:|..|...:..|.|:.|.|..|.|.
Human     8 WLV---WALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRG 69

  Fly    88 EFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNG 152
            .|:  .:..:..::|..:||:.:...:...|..|..:|||.|.:.............|::|.:|.
Human    70 AFA--DVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNH 132

  Fly   153 NPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANL 217
            |.|..|.......||.||:                        |.:.||.|.:|:...|..::.|
Human   133 NRLGSLPRDALGALPDLRS------------------------LRINNNRLRTLAPGTFDALSAL 173

  Fly   218 KTLSLEENPWQCNCKLRKFRGWYVNSRLS---SVSLVCKGPPAQKDRTWDSVDDELFG------- 272
            ..|.|..||:.|.|.|...:.|..::|:|   ..|:.|..|||            |.|
Human   174 SHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPA------------LQGVPVYRLP 226

  Fly   273 ----CPPRVEIFNNEEVQ----NIDIGSNTTFSCLVYGDPLPEVAWEL---NGKILDNDNVLF-E 325
                .||.|.:.....::    .:..|......|:..|.|.|.:.|:|   .|.::....||. |
Human   227 ALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGE 291

  Fly   326 SESIASDK----------------------LW--------------SNLTVFNVTSLDAGTYACT 354
            .:.:.:::                      .|              .:|.|..:::.:||.|.|.
Human   292 DDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCR 356

  Fly   355 GSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMGIFGTVFLLISISFVVCLCKRTTRQHR 419
            ..|.:|:.:.:|.:.::                                          .|...:
Human   357 AHNELGANSTSIRVAVA------------------------------------------ATGPPK 379

  Fly   420 HANKAGVKSSVSFNDQEKKLLDSSVTTTTNDRGDSYGIDNQPTSIGMNKGDSAGMGFNQIEIHAV 484
            ||..||.:........|:|       :|...||:|. :.::|      :|...|.|..::.|...
Human   380 HAPGAGGEPDGQAPTSERK-------STAKGRGNSV-LPSKP------EGKIKGQGLAKVSILGE 430

  Fly   485 ESHRHGSMLVQQQPQQQQVAGGGGMRQQLMQ-VKDSTCGMMSVPTSMAGHAHSHPAQISEE-FPL 547
                     .:.:|::....|.....|.|.. .::..||.......::.||.:..|::... |.|
Human   431 ---------TETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELKPHVFEL 486

  Fly   548 NV 549
            .|
Human   487 GV 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:290566	13/58 (22%)
		leucine-rich repeat	97..120	CDD:275380	4/22 (18%)
		leucine-rich repeat	121..144	CDD:275380	5/22 (23%)
		LRR_4	144..186	CDD:289563	10/41 (24%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		leucine-rich repeat	169..216	CDD:275380	8/46 (17%)
		LRRCT	225..274	CDD:214507	15/62 (24%)
		Ig	295..367	CDD:143165	19/111 (17%)
ISLR2	NP_001123608.1	leucine-rich repeat	36..52	CDD:275380	4/15 (27%)
		LRR_8	52..109	CDD:404697	15/58 (26%)
		LRR 1	52..73		7/22 (32%)
		leucine-rich repeat	53..76	CDD:275380	7/24 (29%)
		LRR 2	76..97		3/20 (15%)
		leucine-rich repeat	77..100	CDD:275380	4/22 (18%)
		LRR_8	99..159	CDD:404697	18/83 (22%)
		LRR 3	100..123		5/22 (23%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR 4	124..145		6/20 (30%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR 5	148..169		8/44 (18%)
		leucine-rich repeat	149..172	CDD:275380	8/46 (17%)
		PCC	154..>228	CDD:188093	23/85 (27%)
		Ig_3	232..359	CDD:404760	21/126 (17%)
		Ig strand B	256..263	CDD:409353	1/6 (17%)
		Ig strand C	269..274	CDD:409353	1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..326		4/38 (11%)
		Ig strand C'	305..307	CDD:409353	0/1 (0%)
		Ig strand D	331..335	CDD:409353	0/3 (0%)
		Ig strand E	338..343	CDD:409353	1/4 (25%)
		Ig strand F	351..359	CDD:409353	3/7 (43%)
		Ig strand G	362..372	CDD:409353	2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..466		22/113 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	656..722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910