DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and LRFN2

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_065788.1	Gene:	LRFN2 / 57497	HGNCID:	21226	Length:	789	Species:	Homo sapiens

Alignment Length:	895	Identity:	190/895 - (21%)
Similarity:	308/895 - (34%)	Gaps:	244/895 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFS 90
            :|:.|.|    :|...|.|:..:.....:|.|..|..:|..:......|.|..|.|.:::|::|:
Human    13 MAFAVVD----ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFA 73

  Fly    91 TL-GLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNP 154
            .: ||::|.   |.::.:.:|...||.:|:.|..:.|..|:|..|.:||..|...|:.|.:|.|.
Human    74 NMTGLVDLT---LSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQ 135

  Fly   155 LKRLAAYQFPILPHLRTLDMHDCLISYID----PM-SLANLNLLEFLNLKNNLLESLSEYVFQHM 214
            |..:|...|.  ..|.||:  |..:||.:    |. |:..:..|..|:|.:|||:.::|..|..:
Human   136 LGGIADEAFE--DFLLTLE--DLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADL 196

  Fly   215 ANLKTLSLEE-----------------------------------NPWQCNCKLRKFRGWYVNSR 244
            ..|..|.|..                                   ||..|||:|...|....:..
Human   197 QKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDD 261

  Fly   245 LSSVSLVCKGPPAQKDRTWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVA 309
            |.:    |..|...|.|.:..|.:|.|.|.|.:...:..::..:: |...|..|...|||.|.:.
Human   262 LET----CGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLE-GQAATLKCKAIGDPSPLIH 321

  Fly   310 WELNGKILDNDNVLFESESIASDKLWSN--LTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSE 372
            |     :..:|.::..|...|   ::.|  |.:|..||.|:|.:.|..:|:.|..|..:.:   .
Human   322 W-----VAPDDRLVGNSSRTA---VYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEV---S 375

  Fly   373 IVQ--HVLEKTPETFWYFGLIMGIFGTVFLLISISFVVCLCKRTTRQHRHANKAGVKSSVSFNDQ 435
            |||  |:...|..|......:..|.|:              .:|:|  ......|.:...|  ..
Human   376 IVQLPHLSNSTSRTAPPKSRLSDITGS--------------SKTSR--GGGGSGGGEPPKS--PP 422

  Fly   436 EKKLLDSSVTTTT---------------------NDRGD-------------SYGIDNQPTSIG- 465
            |:.:|.|.||||:                     |...|             ::.::|..:..|
Human   423 ERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGY 487

  Fly   466 ----MNKGDSAGMGFNQIEIHAVESHRHGSMLVQQQPQQQQVAGG------GGMRQQ-------L 513
                :...|..........|.........:...|.|....|:.||      ||:...       :
Human   488 DLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVI 552

  Fly   514 MQVKDSTCGMMSVPTSMAGHAHSHPAQISEEFPLNVGVFPPPPEFCSNIVP--NPAFGGNIFIRV 576
            :.|:...|. ...|:.||       |.:|..:....|..||||.......|  .|.       :|
Human   553 LMVRYKVCN-HEAPSKMA-------AAVSNVYSQTNGAQPPPPSSAPAGAPPQGPP-------KV 602

  Fly   577 SVTQDMLD-GADLNMYPDLLNIPKRMQDVQES---GAGAVA--------VPEGQFATLPRHTARR 629
            .|..::|| .|.|          .|..|...|   |:|..|        :|..  |..|:.:..|
Human   603 VVRNELLDFTASL----------ARASDSSSSSSLGSGEAAGLGRAPWRIPPS--APRPKPSLDR 655

  Fly   630 GILKKDTSLQQQQQQHQQQHQHQQQQQQQQIQQQQHQQLQQQHQPSGLYTHDEIVTYNLEASGYD 694
             ::....||                    .::.|:.::|.....|:|              .|..
Human   656 -LMGAFASL--------------------DLKSQRKEELLDSRTPAG--------------RGAG 685

  Fly   695 PHQSGYHSNAMELPPPP--------PPPAVTAVVQCHHPSPNNCASCINNAPPPPSACQSPPVEV 751
            ....|:||:...|..||        |.|......:.|.....:.|:.......|..  .|||.:|
Human   686 TSARGHHSDREPLLGPPAARARSLLPLPLEGKAKRSHSFDMGDFAAAAAGGVVPGG--YSPPRKV 748

  Fly   752 TPMRPLDSSAYPKYDNMGRRITASGGLGGSNLSLHDEERYENETLFGQAE 801
                   |:.:.|     |.::.:|.|    |...:.:.......||.:|
Human   749 -------SNIWTK-----RSLSVNGML----LPFEESDLVGARGTFGSSE 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/25 (32%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_4	144..186	CDD:289563	14/46 (30%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		leucine-rich repeat	169..216	CDD:275380	16/51 (31%)
		LRRCT	225..274	CDD:214507	15/48 (31%)
		Ig	295..367	CDD:143165	21/73 (29%)
LRFN2	NP_065788.1	LRR 1	53..74		6/20 (30%)
		leucine-rich repeat	54..77	CDD:275380	6/22 (27%)
		LRR_8	76..136	CDD:316378	20/62 (32%)
		LRR 2	77..98		7/23 (30%)
		leucine-rich repeat	78..101	CDD:275380	7/25 (28%)
		LRR 3	101..122		7/20 (35%)
		leucine-rich repeat	102..125	CDD:275380	8/22 (36%)
		LRR_8	125..185	CDD:316378	19/63 (30%)
		LRR 4	125..146		7/22 (32%)
		leucine-rich repeat	126..150	CDD:275380	8/25 (32%)
		LRR 5	150..171		7/22 (32%)
		leucine-rich repeat	151..174	CDD:275380	6/24 (25%)
		LRR_8	174..>215	CDD:316378	11/40 (28%)
		LRR 6	174..195		8/20 (40%)
		leucine-rich repeat	175..198	CDD:275380	8/22 (36%)
		LRR 7	198..219		3/20 (15%)
		LRRCT	242..286	CDD:214507	15/47 (32%)
		Ig	303..376	CDD:325142	22/83 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..424		8/58 (14%)
		fn3	420..493	CDD:306538	12/74 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..602		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..654		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..702		9/47 (19%)
		PDZ-binding	786..789
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960