DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and lrrc24

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_009297158.1	Gene:	lrrc24 / 565790	ZFINID:	ZDB-GENE-060503-496	Length:	692	Species:	Danio rerio

Alignment Length:	610	Identity:	147/610 - (24%)
Similarity:	237/610 - (38%)	Gaps:	145/610 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFSTLGLLNLQR 99
            ||:|.|.|.|.    ..:..|.|:.:..||..::...|.:.|.||.|..:.:.:.|.||  .|..
Zfish   119 SLACPSGCRCY----SLTVECGSIGIKEIPQGITQGTQTIFLQDNAIGQIRQRDLSDLG--QLHY 177

  Fly   100 IYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFP 164
            :||:.:.:..:...:||:|.:|:|:.|:.|::.::..|.|.|.|.||||||.||.:.||..|.|.
Zfish   178 LYLQNNSISTLEPGAFRSLGLLLELALNGNRIHLITADVFRGLDHLRILYLAGNQINRLEDYTFR 242

  Fly   165 ILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENPWQC 229
            .|..|:.|.:.:.::..:...:|..|:.|..|:|..|.|.:||....:.:.:|:.|.:.:|||:|
Zfish   243 GLQRLQELHLQENVLEVLGDQALVGLSSLALLDLSRNNLRTLSPASLKPLVSLQVLRVTDNPWRC 307

  Fly   230 NCKLRKFRGWYVNSR----LSSVS--LVCKGPPAQKDRTWDSVDDELFGC-PPRVEIFNNEEVQN 287
            :|.|...||| :|..    |||..  ::|..||.....:...|......| ||.|::  ......
Zfish   308 DCALHWLRGW-INEEGQRLLSSAERRMLCAEPPRLSHLSLVEVPPNSLVCIPPVVQL--EPSHLT 369

  Fly   288 IDIGSNTTFSCLVYGDPLPEVAWE--LNGKI------------LDND------------------ 320
            :.:|.:...||...|.|.|:|.|.  .:||.            :|.|
Zfish   370 VRLGESLRVSCQASGYPQPQVTWRKASHGKAQLSPRGLVQEVGMDGDTRNGGRLVTARPGGKGGP 434

  Fly   321 ----------NVLFESESIASDKLWSNLTVFNVTSLDAGTYACTGSN--SIGSMTQNISIYLSEI 373
                      :...:.|:...|.....|.:.|||...||.|.|...|  .:..:|.::|:.:|.
Zfish   435 SSHGPIRGGADDGADRENFDPDTGSGMLFLSNVTVAHAGRYECEAWNPGGVARVTFHLSVNMSS- 498

  Fly   374 VQHVLEKTPETFW-------YF----------------GLIMGIFGTV--------FLLISISFV 407
                 ..:....|       |:                .:.....||.        ..|::::.:
Zfish   499 -----SSSRSEIWPRLHSSSYYHPSSVDVSQEPLYELESMDFNALGTATQTAIAVGISLLALTAL 558

  Fly   408 VCLCKRTTRQHRHANK--AGVKSSVSFNDQEKKLLDSSVTTTTNDRGDSYGIDNQPTSIGMNKGD 470
            :.||...:| ||...|  .|..:|     :|:.:|      ..||..|.      ||:
Zfish   559 LLLCMIYSR-HRQRQKEEGGYGAS-----KEESIL------YVNDYSDG------PTT------- 598

  Fly   471 SAGMGFNQIEIHAVESHRHGSMLVQQQ------PQQQQVAGGGGMRQQLMQVKDSTCGMMSVPTS 529
                 |.|:|.:..|  |...|.|..:      ||...:..|..      .:|.|.|..:..|..
Zfish   599 -----FAQLEEYRDE--RGHEMYVLNRAKPVLAPQPMCIQQGSA------TLKASECQGVLTPGR 650

  Fly   530 MAG-HAHSHPAQISEEFPLN-VGVF 552
            ..| .....||:..|..||: .|:|
Zfish   651 AGGIGPRRAPAEGGEAPPLDPEGLF 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/24 (33%)
		LRR_8	96..155	CDD:290566	22/58 (38%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_4	144..186	CDD:289563	15/41 (37%)
		leucine-rich repeat	145..168	CDD:275380	13/22 (59%)
		leucine-rich repeat	169..216	CDD:275380	11/46 (24%)
		LRRCT	225..274	CDD:214507	18/55 (33%)
		Ig	295..367	CDD:143165	23/115 (20%)
lrrc24	XP_009297158.1	leucine-rich repeat	151..174	CDD:275378	8/24 (33%)
		LRR_8	174..257	CDD:290566	29/82 (35%)
		LRR_4	174..238	CDD:289563	24/63 (38%)
		leucine-rich repeat	175..222	CDD:275378	13/46 (28%)
		leucine-rich repeat	199..218	CDD:275380	5/18 (28%)
		LRR_8	222..304	CDD:290566	26/81 (32%)
		LRR_4	222..258	CDD:289563	15/35 (43%)
		leucine-rich repeat	223..246	CDD:275378	13/22 (59%)
		leucine-rich repeat	247..294	CDD:275378	11/46 (24%)
		leucine-rich repeat	295..307	CDD:275378	5/11 (45%)
		LRRCT	303..356	CDD:214507	17/53 (32%)
		IG_like	365..494	CDD:214653	24/128 (19%)
		Ig	376..491	CDD:143165	23/114 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910