DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and lrit3a

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001122166.1	Gene:	lrit3a / 558559	ZFINID:	ZDB-GENE-080723-63	Length:	636	Species:	Danio rerio

Alignment Length:	400	Identity:	95/400 - (23%)
Similarity:	163/400 - (40%)	Gaps:	95/400 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LVAWTVADDWSLS---CASNCTCKW-----TNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHI 81
            |||..:...||::   |.|.|||.:     ..|.:|.:|:...::.||              .::
Zfish     5 LVAQVLLGCWSVAQPFCPSQCTCVYHGRSDGTGSRSVLCNDPDMSDIP--------------VNV 55

  Fly    82 PYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLR 146
            |            |:..::.::|:.|:.:..|:|..|..|..:.::.|.:..:|..:|.....|.
Zfish    56 P------------LDTVKLRVEKTAVRRVPTEAFYYLSELRYLWITYNSITSVDPGSFYNLKVLH 108

  Fly   147 ILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESL-SEYV 210
            .|.|:||.:..........:|.|:|||:|:..::.:...:...|..:.:|::.:|.|.:| |:.|
Zfish   109 ELRLDGNMIATFPWESLKEMPSLKTLDLHNNRLTSVPVEAAPYLINITYLDISSNKLTTLPSDLV 173

  Fly   211 --------FQHMANL--KT-LSLEENPWQCNCKLRKFRGWYVNSRLSSVSLV-------CKGPPA 257
                    .|..||.  || |.|::|||.|:|::.|.   ...|:::.:.:|       |.||
Zfish   174 DIWPPFSGIQPSANTSQKTVLGLQDNPWYCDCRISKL---IELSKMAGIPVVLMDQVLTCSGP-- 233

  Fly   258 QKDRTWDSVDDELFGCPPRVEIFNNEEVQNI--------------DIGSNTTFSCLVYGDPLPEV 308
                      :.|.|.     :|...|:...              .:|||....|...|.|.|.:
Zfish   234 ----------EHLSGV-----LFQRAELDQCVKPTVMTSATKITSPLGSNVLLRCDANGFPTPTL 283

  Fly   309 AW-ELNGKILDNDNVLFESESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSE 372
            .| ..:|.:::|..|   .||......||.|::.::...|||.|.|...|..|    |...|::.
Zfish   284 LWTTADGSVVNNTVV---QESPGEGVRWSILSLHSIVFKDAGDYRCKAKNVAG----NAEAYITL 341

  Fly   373 IVQHVLEKTP 382
            .|..|...||
Zfish   342 SVDGVQPTTP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	1/24 (4%)
		LRR_8	96..155	CDD:290566	14/58 (24%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	4/22 (18%)
		LRR_4	144..186	CDD:289563	11/41 (27%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		leucine-rich repeat	169..216	CDD:275380	13/55 (24%)
		LRRCT	225..274	CDD:214507	13/55 (24%)
		Ig	295..367	CDD:143165	21/72 (29%)
lrit3a	NP_001122166.1	LRR_8	81..141	CDD:290566	15/59 (25%)
		leucine-rich repeat	83..106	CDD:275378	4/22 (18%)
		LRR_4	107..145	CDD:289563	11/37 (30%)
		leucine-rich repeat	107..130	CDD:275378	5/22 (23%)
		LRR_8	129..>171	CDD:290566	11/41 (27%)
		LRR_4	129..170	CDD:289563	11/40 (28%)
		leucine-rich repeat	131..154	CDD:275378	6/22 (27%)
		leucine-rich repeat	155..168	CDD:275378	3/12 (25%)
		TPKR_C2	199..249	CDD:301599	15/69 (22%)
		Ig	252..343	CDD:299845	25/97 (26%)
		IG_like	261..343	CDD:214653	25/88 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910