DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and Lrit3

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006232069.1	Gene:	Lrit3 / 502596	RGDID:	1559637	Length:	702	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	97/402 - (24%)
Similarity:	168/402 - (41%)	Gaps:	83/402 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WILLCL-VAWTVADDWSLSCASNCTCKW-----TNGKKSAICSSLQLTTIPNTLSTELQVLVLND 78
            |:..|| :..:.....:.:|.|.|:|::     .:|.:|.:|:.|.:..:|..|..:...|.:..
  Rat     2 WLFACLCLVLSFLGGVNCTCPSQCSCEYHGRHEGSGSRSVLCNDLDMNEVPTNLPVDTAKLRIEK 66

  Fly    79 NHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGND 143
            ..:..:..|.|  ..|:.||.::|..:.|..|...||.|||.|.|:.|..|.|.
  Rat    67 TVVRRIPAEAF--YYLVELQYLWLTYNSVASIETRSFYNLKQLHELRLDGNSLT----------- 118

  Fly   144 RLRILYLNGNPLKRLAAYQFP-----ILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLL 203
                              :||     .:|||||||:|:..|:.:...::..|..|..|:|.:|.|
  Rat   119 ------------------EFPWASLLDMPHLRTLDLHNNRITSVTNEAVRYLRNLTCLDLSSNRL 165

  Fly   204 ESL-SEYV--FQHMANLKT-----------LSLEENPWQCNCKLRKFRGWYVNSRLSSVS----- 249
            .:| .:::  :.|:|...:           |.|::|||.|:|.:.|.      ..||.|:
  Rat   166 TTLPPDFLDSWSHLAMTPSRSPDLPPKRIILGLQDNPWFCDCHISKV------IELSKVADHAAV 224

  Fly   250 -----LVCKGPPAQKDRTWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVA 309
                 :||..|...:...:..|  ||..|.....:.:..::.:. :|||....|...|.|.|::.
  Rat   225 LLDPLMVCSEPEYLQGIAFQRV--ELEKCLKPSVMMSATKITSA-LGSNVLLRCDAKGYPTPQLM 286

  Fly   310 WELNGKILDNDNVLFES--ESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSE 372
            |..:.....|..|:.||  |.:.    ||.|::..:|..|||.|:|...|..|:....:::.:..
  Rat   287 WTRSDSSPVNATVIQESPGEGVR----WSILSLTGITYRDAGDYSCKAKNLAGTSEAVVTVTVVG 347

  Fly   373 IVQHVLEKTPET 384
            :....|  :|:|
  Rat   348 VATTTL--SPDT 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	4/24 (17%)
		LRR_8	96..155	CDD:290566	15/58 (26%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	5/22 (23%)
		LRR_4	144..186	CDD:289563	11/46 (24%)
		leucine-rich repeat	145..168	CDD:275380	2/27 (7%)
		leucine-rich repeat	169..216	CDD:275380	15/49 (31%)
		LRRCT	225..274	CDD:214507	15/58 (26%)
		Ig	295..367	CDD:143165	21/73 (29%)
Lrit3	XP_006232069.1	LRR_8	61..117	CDD:290566	18/57 (32%)
		LRR_4	83..121	CDD:289563	15/66 (23%)
		leucine-rich repeat	83..106	CDD:275378	9/22 (41%)
		LRR_8	105..165	CDD:290566	22/88 (25%)
		LRR_4	105..146	CDD:289563	17/69 (25%)
		leucine-rich repeat	107..130	CDD:275378	7/51 (14%)
		LRR_4	129..170	CDD:289563	16/40 (40%)
		leucine-rich repeat	131..154	CDD:275378	8/22 (36%)
		leucine-rich repeat	155..168	CDD:275378	5/12 (42%)
		IGc2	268..335	CDD:197706	23/70 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910