DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and vasn

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001005036.1	Gene:	vasn / 448556	XenbaseID:	XB-GENE-941552	Length:	661	Species:	Xenopus tropicalis

Alignment Length:	669	Identity:	135/669 - (20%)
Similarity:	215/669 - (32%)	Gaps:	236/669 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYL 84
            ||:|...|..:..:   .|.:.|.|   |..::..|.:.:.:..|.::..:...|.:.:|.|..:
Frog     7 WIILLATAQQMITE---GCPAGCQC---NTPQTVFCLARKNSNFPRSVPPDTLNLYVFENGISSI 65

  Fly    85 NREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILY 149
              ||.|.:||..|..:.|..:::..:....||||..|..:||:.|:|..:..|||.|..||..||
Frog    66 --EESSFIGLNGLHLLDLSHNQLSSLPGGVFRNLANLSNLDLTSNQLTEISADTFQGLSRLERLY 128

  Fly   150 LNGNPLKRLAAYQFP---------------------ILPHLRTLDMHDCLISY------------ 181
            ||||.::.:....|.                     .||||..||     :||
Frog   129 LNGNRIRSIHPEAFKGIESLLELKLSNNQLVTPPAFSLPHLLLLD-----LSYNAIPVIQQGVFN 188

  Fly   182 ---IDPMSLANLNLLEF---------------------------------LNLKNNL-------- 202
               |:.:.||.|.|.|.                                 ||:..|:
Frog   189 AGNIESLRLAGLGLKEVPEELLSGLKNLHELDLSDNQLDKVPPGLHGLTKLNIAGNVGFSQIQVD 253

  Fly   203 -----------------LESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVN-SRLSSVS 249
                             |::|.:.:|:....|:.:||.:||:.|.|.|    ||... .|:|.|.
Frog   254 DLSNLPALQELDLSGLSLQTLPKGLFRSSKRLRAVSLAQNPFNCVCSL----GWLSEWMRVSGVV 314

  Fly   250 LV------CKGPPAQKDRTWDSVDDELFGCP---------------------------------- 274
            |:      |..||....:|...:.|..:|||
Frog   315 LLRPDETRCHFPPKNAGKTLRQLRDSEYGCPAPTTIQMPSTMPPSTTTGPPTTTKHLQTEAPTTA 379

  Fly   275 -------PRVEIFNNEEVQNIDIGSNTTF----SCLVYG----DP-------------------- 304
                   |..|  ..|:.|........|.    :||..|    ||
Frog   380 STTTTTIPHQE--QEEDTQPFQFDFEDTLCPPQTCLNGGSCHLDPTGQLECECPPGFQGTYCETG 442

  Fly   305 --LPEVAWEL---NGKILD----NDNVLFESESIASDKLWS-NLTVFNVTSLD------------ 347
              .|.|..|:   ..||::    :..|..:|.|...:||.: .|||.|:...|
Frog   443 PVTPAVVTEMYIEQVKIIEVTVSSIRVDLQSYSQNKEKLRAIRLTVRNLYGADRRPMIYKLPPTL 507

  Fly   348 -----------AGTYACTGSNSIGSMTQNI---SIYLSEIVQHVLEKTPETFWYFGLIM--GIFG 396
                       :..:.|.||...|...:::   :..|.|..:|..:.|........|::  .:..
Frog   508 PEYTVRALSSNSSYWVCLGSQGEGGPEEDLCTETHTLGEPPKHSPQVTQSQEGNLTLVLVPAVAA 572

  Fly   397 TVFLLISISFVVCLCKRTTRQHRHANKA------GVKSSVSFNDQEKKLL-DSSVTTTTNDRGDS 454
            .:.|..:::...|..:|...:.......      |||..:....:.|||. |.:....|....:.
Frog   573 GILLSAAVAAAACYARRRKGKGHSVEDGGPLEMDGVKKGLDGKGEVKKLSEDPTGPEKTGAESEE 637

  Fly   455 YGIDNQPTSIGMNKGDSAG 473
            ..:|:  |.||.|.....|
Frog   638 PLMDS--TRIGNNNDAPTG 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/24 (33%)
		LRR_8	96..155	CDD:290566	23/58 (40%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		LRR_4	144..186	CDD:289563	18/77 (23%)
		leucine-rich repeat	145..168	CDD:275380	9/43 (21%)
		leucine-rich repeat	169..216	CDD:275380	17/119 (14%)
		LRRCT	225..274	CDD:214507	17/55 (31%)
		Ig	295..367	CDD:143165	25/135 (19%)
vasn	NP_001005036.1	LRRNT	21..52	CDD:214470	6/33 (18%)
		leucine-rich repeat	52..75	CDD:275380	8/24 (33%)
		LRR 1	52..72		6/21 (29%)
		LRR	<60..>276	CDD:227223	50/222 (23%)
		LRR 2	75..96		3/20 (15%)
		leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		LRR_8	99..158	CDD:338972	18/58 (31%)
		LRR 3	99..120		8/20 (40%)
		leucine-rich repeat	100..123	CDD:275380	9/22 (41%)
		LRR 4	123..144		9/20 (45%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR 5	147..168		1/20 (5%)
		leucine-rich repeat	148..169	CDD:275380	2/20 (10%)
		LRR 6	169..189		5/24 (21%)
		leucine-rich repeat	170..191	CDD:275380	4/25 (16%)
		LRR 7	191..212		6/20 (30%)
		leucine-rich repeat	192..215	CDD:275380	6/22 (27%)
		LRR 8	215..237		0/21 (0%)
		leucine-rich repeat	216..235	CDD:275380	0/18 (0%)
		leucine-rich repeat	236..260	CDD:275380	3/23 (13%)
		LRR 9	238..258		3/19 (16%)
		LRR 10	259..281		3/21 (14%)
		leucine-rich repeat	261..281	CDD:275380	3/19 (16%)
		PCC	265..>344	CDD:188093	22/82 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..395		3/48 (6%)
		EGF	407..438	CDD:333761	5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	591..661		14/66 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49155
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000