DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek6 and LRRC24

DIOPT Version :9

Sequence 1:NP_001263151.1 Gene:kek6 / 43729 FlyBaseID:FBgn0039862 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001019849.2 Gene:LRRC24 / 441381 HGNCID:28947 Length:513 Species:Homo sapiens


Alignment Length:540 Identity:142/540 - (26%)
Similarity:216/540 - (40%) Gaps:99/540 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 RTPRTLPVCWILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLV 75
            |.|..||:..:||.|.|        ..|.:.|.|.    ..:..|.:|:|..:|..:....|.|.
Human     4 RAPALLPLLLLLLPLRA--------AGCPAACRCY----SATVECGALRLRVVPLGIPPGTQTLF 56

  Fly    76 LNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFM 140
            |.||:|..|  |..:...|..|:|:||..:.::.:...:||....|:|:.|:.|:|..|....|:
Human    57 LQDNNIARL--EPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFV 119

  Fly   141 GNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLES 205
            |..:||:|||.||.|.||..:.|..||.|:.|.:.:..|..::..:||.|:.|..|:|..|.|.:
Human   120 GLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGT 184

  Fly   206 LSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGW-------YVNSRLSSVSLVCKGPPAQKDRTW 263
            :|....|.:|:|:.|.|.||||:|:|.|.....|       .:.||  ...::|..||....::.
Human   185 ISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSR--DRKIMCAEPPRLALQSL 247

  Fly   264 DSVDDELFGC-PPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAW---------------EL 312
            ..|......| ||.|.:...|...|  :|.:...:|...|.|.|.|.|               :|
Human   248 LDVSHSSLICIPPSVHVQPLELTAN--LGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQL 310

  Fly   313 NGKILDNDNVLFESESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHV 377
            .|.:|....      ..|||.....|.:.|:|...||.|.|..||:.|:......:.::...|..
Human   311 EGGLLGLGG------HSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNASRQQP 369

  Fly   378 ---------------LEKTPE----TFWYFGLI--MGIFGTVFL--LISISFVVCLCKRTTRQHR 419
                           .|..||    .|...|:.  ..|...:.|  |.::..|..:|:|..|:.:
Human   370 QQPAQPPPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTALLLVAMICRRRRRRKK 434

  Fly   420 HANKAGVKSSVSFNDQEKKLLDSSVT-----TTTNDRGDSYGIDNQ------------PTSIGMN 467
            .....| :.::..||    .||...|     ...::||....:.|:            |...|..
Human   435 ARGPPG-EGALFVND----YLDGPCTFAQLEELRDERGHEMFVINRSKPLFAEGPAEAPADCGPE 494

  Fly   468 KGDSAGMGFN-----QIEIH 482
            :|  ||.|..     ..|||
Human   495 QG--AGPGLRVPPPVAYEIH 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek6NP_001263151.1 leucine-rich repeat 71..96 CDD:275380 9/24 (38%)
LRR_8 96..155 CDD:290566 21/58 (36%)
leucine-rich repeat 97..120 CDD:275380 6/22 (27%)
leucine-rich repeat 121..144 CDD:275380 8/22 (36%)
LRR_4 144..186 CDD:289563 16/41 (39%)
leucine-rich repeat 145..168 CDD:275380 12/22 (55%)
leucine-rich repeat 169..216 CDD:275380 13/46 (28%)
LRRCT 225..274 CDD:214507 14/56 (25%)
Ig 295..367 CDD:143165 22/86 (26%)
LRRC24NP_001019849.2 LRR_RI 49..>158 CDD:238064 38/110 (35%)
LRR_8 <50..86 CDD:290566 13/37 (35%)
LRR 1 51..72 8/22 (36%)
leucine-rich repeat 53..75 CDD:275380 9/23 (39%)
LRR 2 75..96 5/20 (25%)
LRR_8 76..134 CDD:290566 21/57 (37%)
leucine-rich repeat 76..99 CDD:275380 6/22 (27%)
LRR 3 99..120 7/20 (35%)
leucine-rich repeat 100..123 CDD:275380 8/22 (36%)
LRR_8 123..205 CDD:290566 31/81 (38%)
LRR 4 123..144 11/20 (55%)
leucine-rich repeat 124..147 CDD:275380 12/22 (55%)
LRR 5 147..168 4/20 (20%)
leucine-rich repeat 148..171 CDD:275380 6/22 (27%)
LRR 6 171..192 6/20 (30%)
leucine-rich repeat 172..195 CDD:275380 7/22 (32%)
LRRCT 204..257 CDD:214507 13/54 (24%)
Ig 259..364 CDD:299845 28/112 (25%)
IG_like 266..362 CDD:214653 25/103 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 365..391 3/25 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
32.870

Return to query results.
Submit another query.