DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and chp

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001263137.1	Gene:	chp / 43690	FlyBaseID:	FBgn0267435	Length:	1338	Species:	Drosophila melanogaster

Alignment Length:	717	Identity:	149/717 - (20%)
Similarity:	249/717 - (34%)	Gaps:	242/717 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 LQVLVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLD 135
            |::|.|:||.|..:.:..|.......|:.|.|:.:.:..|.:.:|.:|:.|.::.|.|||::.::
  Fly   549 LRLLELHDNRIEQVLKGTFQGDIHSKLEEISLRFNHLTSISQHTFFDLEALRKLHLDDNKIDKIE 613

  Fly   136 KDTFMGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDM-----HDCLISYIDPM-SLANLNLLE 194
            :..||..|.|..|.|.||.:..||...|..||.|..|||     .:....|.|.: :|:|||
  Fly   614 RRAFMNLDELEYLSLRGNKINNLADESFQNLPKLEILDMAFNQLPNFNFDYFDQVGTLSNLN--- 675

  Fly   195 FLNLKNNLLESL---------SEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSL 250
             :|:.:|.:..|         :|:...:.:|:|.|.|..|                     ::|:
  Fly   676 -VNVSHNQIRQLMYNSSWSGRNEHGGMYHSNIKILDLSHN---------------------NISI 718

  Fly   251 VCKG--PPAQKDRT-----WDSVDD---ELFGCPPRVE----------------IFNNEEVQNID 289
            :..|  .||:...|     ::|:.:   ::||..|.::                ..|.:::|.:.
  Fly   719 IHPGYFRPAEISLTHLHLGYNSLMNTTRDVFGNMPHLQWLDLSYNWIHELDFDAFKNTKQLQLVF 783

  Fly   290 IGSNTTFSCLVYGDPLPEVAWE-LNG-KILD---------NDNVLFE-----------------S 326
            .|.|       |...:|:..:: :.| :|:|         .||:.:.                 |
  Fly   784 FGHN-------YLSDIPQDIFKPVQGLRIVDFSHNHLRGLPDNLFYNGGMEKLDVSHNMMLKIPS 841

  Fly   327 ESIAS-------DKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQ-NISI-YLSEIVQHVLEKTP 382
            .|::|       :...||..:..:.|:|.       ||...|:.. :||. ||..|...|....|
  Fly   842 SSLSSLAALTLCELHLSNNFISTIHSMDL-------SNKFRSLRYLDISYNYLLRIDDAVFATMP 899

  Fly   383 -----------------ETFWYFGLIMGIFGTVFLL----ISISFVVCLCKRTTRQHR--HANKA 424
                             ::|      ||:..::..|    ||:|.|..:..:..|:.|  :....
  Fly   900 KLAVLDLSHNRDLKVMDKSF------MGLENSLIKLGLENISLSTVPEIRLKYLREFRLGYNELP 958

  Fly   425 GVKSSVSFNDQEKKLLDSSVTTTTNDRGDSYGI---------DNQPTSIGMNKGDSAGMGFNQIE 480
            .:...::.|....::||.|....||....:..:         .|..||:..|..|........::
  Fly   959 SIPQELAHNMSNLRMLDLSNNDLTNVPLMTQALPHLRRLMLSGNPITSLNNNSFDGVNEDLEMLD 1023

  Fly   481 I-----HAVE------------------SH----------RHGSMLVQ-----QQPQQQQVAGGG 507
            |     |..|                  ||          ||...:.|     .||..:.|..|.
  Fly  1024 ISNFRLHYFEYGCLDSLPHLRSLKLTAYSHLEHFNIPHLLRHHYNIRQLWIEAPQPFTRIVKKGS 1088

  Fly   508 GMRQ--QLMQVKDSTCGMMSVPTSMAGHAHSHPAQISEEFP----------------------LN 548
            |..|  |.:|:.:.|    .:...|.||..|....|:...|                      .|
  Fly  1089 GPTQEMQTLQLGNPT----DLQREMEGHLPSKLTNITFSGPQFTNLNERILRGMRSPYLYMQLFN 1149

  Fly   549 VGVFPPPPEF------CSNI-------------VPNPAFGGNIFIRVSV--TQDMLDGADLNMYP 592
            ..:...||.|      ..||             :|||..|...::..||  |...:...|||...
  Fly  1150 TSLQALPPNFFKYMGRVRNISLDIRYHNRNLKKIPNPNTGAVPYLPNSVFLTDLKMSHTDLNCDC 1214

  Fly   593 DL 594
            ||
  Fly  1215 DL 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_4	144..186	CDD:289563	16/47 (34%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		leucine-rich repeat	169..216	CDD:275380	14/61 (23%)
		LRRCT	225..274	CDD:214507	9/58 (16%)
		Ig	295..367	CDD:143165	17/107 (16%)
chp	NP_001263137.1	leucine-rich repeat	84..103	CDD:275380
		LRR_8	102..163	CDD:290566
		leucine-rich repeat	104..128	CDD:275380
		LRR_RI	<128..261	CDD:238064
		leucine-rich repeat	129..152	CDD:275380
		LRR_8	152..212	CDD:290566
		leucine-rich repeat	153..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR_8	202..261	CDD:290566
		leucine-rich repeat	202..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..279	CDD:275380
		leucine-rich repeat	280..326	CDD:275380
		LRR_8	326..386	CDD:290566
		leucine-rich repeat	327..348	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	426..450	CDD:275378
		LRR_RI	<448..651	CDD:238064	32/101 (32%)
		leucine-rich repeat	451..474	CDD:275380
		LRR_8	473..559	CDD:290566	5/9 (56%)
		leucine-rich repeat	475..524	CDD:275380
		leucine-rich repeat	500..519	CDD:275380
		leucine-rich repeat	525..548	CDD:275380
		leucine-rich repeat	549..574	CDD:275380	7/24 (29%)
		LRR_8	573..633	CDD:290566	19/59 (32%)
		leucine-rich repeat	575..598	CDD:275380	6/22 (27%)
		leucine-rich repeat	599..622	CDD:275380	7/22 (32%)
		LRR_8	622..683	CDD:290566	22/64 (34%)
		leucine-rich repeat	623..646	CDD:275380	9/22 (41%)
		leucine-rich repeat	647..730	CDD:275380	23/107 (21%)
		leucine-rich repeat	648..673	CDD:275380	6/24 (25%)
		leucine-rich repeat	674..705	CDD:275380	6/34 (18%)
		LRR_8	704..763	CDD:290566	14/79 (18%)
		leucine-rich repeat	731..754	CDD:275380	4/22 (18%)
		LRR_8	753..813	CDD:290566	10/66 (15%)
		leucine-rich repeat	755..778	CDD:275380	1/22 (5%)
		leucine-rich repeat	779..802	CDD:275380	5/29 (17%)
		leucine-rich repeat	803..823	CDD:275380	4/19 (21%)
		leucine-rich repeat	852..876	CDD:275380	6/30 (20%)
		LRR_8	854..910	CDD:290566	14/62 (23%)
		LRR_RI	<877..>1006	CDD:238064	24/134 (18%)
		leucine-rich repeat	877..900	CDD:275380	6/22 (27%)
		leucine-rich repeat	901..925	CDD:275380	3/29 (10%)
		leucine-rich repeat	926..946	CDD:275380	5/19 (26%)
		LRR_8	947..1004	CDD:290566	9/56 (16%)
		leucine-rich repeat	947..970	CDD:275380	3/22 (14%)
		leucine-rich repeat	971..993	CDD:275380	5/21 (24%)
		LRR_8	992..1049	CDD:290566	8/56 (14%)
		leucine-rich repeat	994..1014	CDD:275380	4/19 (21%)
		leucine-rich repeat	1019..1042	CDD:275380	3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453723
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840