DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and caps

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	1002	Identity:	193/1002 - (19%)
Similarity:	312/1002 - (31%)	Gaps:	387/1002 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MDRRRSRTPRTLP-------VCWIL-LCLVAWTVADDWSL-SCASNCTCK--------------- 45
            |.|||:.|....|       :|..| ||||..|:.....| :|.:.|.|.
  Fly     1 MSRRRAITMSLAPHLGQAFSLCLCLCLCLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDV 65

  Fly    46 -------------WTNGKKSAICSSLQ--------------LTTIPN---TLSTELQVLVLNDNH 80
                         ..|.|...|.||:|              :.|||.   ....:||.|.|:.|.
  Fly    66 LPIALNPAIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNK 130

  Fly    81 IPYLNREEF---STLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGN 142
            |..::.:.|   ||:.:|||:...:  :|::|   .:|..:..|.|::|..|::..:|.....|.
  Fly   131 IGQVSNKTFLGLSTISVLNLRGNLI--AELEY---RTFSPMVKLAELNLGQNRISHIDPHALDGL 190

  Fly   143 DRLRILYLNGNPLKR-----------------LAAYQFPILP--------HLRTLDMHDCLISYI 182
            |.||:|||:.|.|..                 |....|..:|        .|..||:....:..|
  Fly   191 DNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNI 255

  Fly   183 DPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCNCK-----LRKFRGWYVN 242
            ...:|..|..|.||:|.:|.|.::....||.:..|:.|::.:|.::....     ||:.|
  Fly   256 SGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELR----- 315

  Fly   243 SRLSSVSLVCKGPPAQKDRTWDSVDDELFGCPPRVE---IFNNEEVQNIDIGSN---TTFSCLVY 301
                  .|...|  ||:.|              |||   ...|..::::::.||   ...|.:..
  Fly   316 ------HLELTG--AQRLR--------------RVESGAFSGNTNLEHLNLSSNKQLNELSSIAL 358

  Fly   302 GDPLPEVAWELNGKILDNDNVLFESESIAS-DK---LWSNLTVFNVTSLDAGTYAC--------- 353
            |. ||.::           .|:.::..::| |:   .|::|...:   |....:.|
  Fly   359 GG-LPHLS-----------TVVLKANQLSSLDEGLVPWADLQTLD---LSENPFECDCRLLWLRH 408

  Fly   354 --TGSNSIGSMTQNISIYLSEI----VQHVLEKTPETFWYFG-----LIMGIF--GTVFLLISIS 405
              ...|:.|.....|..|.:.:    :.|:.|  |......|     .|:||.  ....|:.:::
  Fly   409 LLVSRNASGQYAPVICAYPTALRDLPLAHLAE--PLLGCAHGAASKQAIIGILVVACAALITTLA 471

  Fly   406 FVVCLCKRTTRQHRHANKAGVKSSVSFNDQEKKLLDSSVTTTTNDRGDSYGIDNQPTSIGMNKGD 470
            .|:..|:...|:                                                |.||.
  Fly   472 LVLYTCRHRIRE------------------------------------------------MLKGH 488

  Fly   471 SAGMGFNQIEIHAVESHRHGSMLVQQQPQQQQVAGGGGMRQQLMQVKDSTCGMMSVPTS-----M 530
            || :|..:.|.....|        .::...:...||||:.                |.:     :
  Fly   489 SA-LGRKEREYQKTFS--------DEEYMSRPPPGGGGVH----------------PAAGGYPYI 528

  Fly   531 AGHAHSHPAQISEEFPLNVGVFPPPPEFCSNIVPNPAFGGNIFIRVSVTQDMLDGADLNMYPDLL 595
            ||::...|.   .|..|..   ||||:     :.....||.........|.             |
  Fly   529 AGNSRMIPV---TELXLEA---PPPPQ-----LRGRGGGGGASTASGAVQQ-------------L 569

  Fly   596 NIPKRMQDVQESGAGAVAVPEGQFATLPRHTARRGILKKDTSLQQQQQQHQQQHQHQQQQQQQQI 660
            .:|..:.....|           ||.|..       :...|:..||||..|||...:....||.:
  Fly   570 QVPSAVDQASNS-----------FAQLSH-------IHYMTNNGQQQQAQQQQSTSKMHHSQQDM 616

  Fly   661 Q---------------------QQQHQQLQQQHQP--SGL------YTHDEIVTYNLEASGY--- 693
            :                     ..|...|....||  :|:      :.|::..::|....|.
  Fly   617 RLLACNGGKPLNATSLPRHRPPVVQESTLSHYSQPLANGIRLTQDHFNHNQNQSHNQHYGGVYAK 681

  Fly   694 ------DP---HQSGYHSNAM--ELPPPPPPPAVTAVVQCHHPSPNNCASCINNAPPPPSACQSP 747
                  :|   |.:.::|..:  :|||.|.|                       .||||:
  Fly   682 PCDAMSEPGYIHNNSHYSLPLDHDLPPSPTP-----------------------TPPPPA----- 718

  Fly   748 PVEVTPMRPLDSSAYPKYDNMGRR------------------------ITASGGLGGSNLSLHDE 788
                .|:|.....|....:..|||                        :...|.:|.:|.||...
  Fly   719 ----LPLRNGVGMALIHGNTTGRRSFNNNNNVSTLSNNNHHGIGGGVGVAVGGTVGNNNGSLRRY 779

  Fly   789 ERYENETLFGQAESQTKGMPEQSQDLH 815
            ..|..:|......:..|..|:...:||
  Fly   780 HXYPAKTCGTLGRTIIKTRPDPDIELH 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	9/27 (33%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	4/22 (18%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	14/66 (21%)
		leucine-rich repeat	145..168	CDD:275380	10/47 (21%)
		leucine-rich repeat	169..216	CDD:275380	14/46 (30%)
		LRRCT	225..274	CDD:214507	9/53 (17%)
		Ig	295..367	CDD:143165	13/86 (15%)
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	6/20 (30%)
		LRR_8	96..155	CDD:290566	15/58 (26%)
		leucine-rich repeat	97..120	CDD:275380	3/22 (14%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_8	143..201	CDD:290566	20/62 (32%)
		leucine-rich repeat	145..168	CDD:275380	6/27 (22%)
		LRR_RI	147..397	CDD:238064	64/296 (22%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		leucine-rich repeat	193..217	CDD:275380	7/23 (30%)
		LRR_8	217..276	CDD:290566	14/58 (24%)
		leucine-rich repeat	218..241	CDD:275380	3/22 (14%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		LRR_8	265..321	CDD:290566	15/66 (23%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		LRR_8	312..374	CDD:290566	18/100 (18%)
		leucine-rich repeat	314..335	CDD:275380	9/47 (19%)
		leucine-rich repeat	339..363	CDD:275380	5/24 (21%)
		LRRCT	395..445	CDD:214507	8/51 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453524
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930