DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek6 and trn

DIOPT Version :9

Sequence 1:NP_001263151.1 Gene:kek6 / 43729 FlyBaseID:FBgn0039862 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster


Alignment Length:858 Identity:163/858 - (18%)
Similarity:287/858 - (33%) Gaps:243/858 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 WILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYL 84
            |.:|..:....|...: :|...|.|  .:......|...||..:|..|:..:|.||:..|.|..:
  Fly    13 WCILASIGVEPAAGLA-NCPPGCQC--DDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTI 74

  Fly    85 NR--EEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRI 147
            :.  :.::.|..|:     |..:.:..|.:.:|...|.|.|:.|:.||:..:...||:|...:.:
  Fly    75 DSSIQFYAELTFLD-----LSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTV 134

  Fly   148 LYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSE-YVF 211
            |.|.||.:..|....|..|..:..|::.:..|.|:||.:...|:.|..|.|.:|.|.::.: .:|
  Fly   135 LNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIF 199

  Fly   212 QHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSLVCKGPP-----------AQKDRTWDS 265
            |.|.:|..|.|..|..| :.:...|:.....:||.     .||..           .|:.|..|.
  Fly   200 QAMPSLAELFLGMNTLQ-SIQADAFQDLKGLTRLE-----LKGASLRNISHDSFLGLQELRILDL 258

  Fly   266 VDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAW---------ELNGKI----- 316
            .|:.|... |.|.:.....::.:.:|.|..       :.:.|.|:         |:||.:     
  Fly   259 SDNRLDRI-PSVGLSKLVRLEQLSLGQNDF-------EVISEGAFMGLKQLKRLEVNGALRLKRV 315

  Fly   317 -----LDNDNVLFESESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNI----SIYLSE 372
                 .||.|:  |..:::|:|:...:....::.|....:....:|::.|:.:.:    .:...:
  Fly   316 MTGAFSDNGNL--EYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLD 378

  Fly   373 IVQHVLEKTPETFWYFGLIMGIFGTVFLLISISFVVCLCKRTTRQH--RHANKAGVKSSVSFNDQ 435
            :.::.|.......|...|::....:   ...:|.::|......|..  ||.|.|  ....:..|.
  Fly   379 LSENPLSCDCRVMWLHNLLVAKNAS---QDDVSELLCEFPERLRGESLRHLNPA--MMGCTHADP 438

  Fly   436 EKK------LLDSSVTTTT--------------NDRGDSYGIDNQPTSIGMNKGDSAGMGFNQIE 480
            .|:      |:.|:.|.|.              ..:|..:|              ::.:|..:.|
  Fly   439 RKQALIGALLVGSAATITALALVLYRCRHKIRETIKGGLWG--------------NSALGRKERE 489

  Fly   481 IHA-------VESHRHGSMLVQQQPQQQQVAGGGGMRQQLMQVKDSTCGMMSVPTSMAGH----- 533
            ...       :..|:|.                                    |.|:..|     
  Fly   490 YQKTFCDEDYMSRHQHH------------------------------------PCSLGIHSTFPN 518

  Fly   534 ---AHSHPAQISE----EFPLN-VGVFPPPPEFCSNIVPNPAFGGNIFIRVSVTQDMLDGADLNM 590
               |..||.....    ..|:| :|...|..:|...:||              |..|:....||.
  Fly   519 TYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQLVVP--------------TATMISEKKLNN 569

  Fly   591 YPDLLNIPKRMQDVQESGAGAVAVPEGQFATLPRHTARRGILKKDTSLQQQQQQHQQQHQHQQ-- 653
            ...|::          .|    |:.:.....|...:|..|   :|...|..|..|..:.|...  
  Fly   570 NKALVS----------QG----AIDDSASFVLHMKSATMG---RDVHQQNPQLNHYTKPQFLSAT 617

  Fly   654 ------------------------QQQQQQIQQQQHQQLQQQHQPSGLYTHDEIVTYNLEASGYD 694
                                    .|.|.::.|:..:|.:...|..|    .||:.:|.      
  Fly   618 ATVGDSCYSYADVPMVHGAPLGGPNQPQLRLTQEHFKQRELYDQEMG----SEILDHNY------ 672

  Fly   695 PHQSGYHSNAME------LPPPPP-PPAVTAVVQCHHPSPNN-CASCINNAPPPPSACQSPPVEV 751
            .:.:.::|..:|      .|.||| |||:        |..|. ||:....:....||.|......
  Fly   673 IYSNTHYSMPLEQLGRSKTPTPPPMPPAL--------PLRNGLCATTGRRSFQQKSASQKQQQNN 729

  Fly   752 TPMRPL--DSSAY 762
            ..:|..  .||.|
  Fly   730 NTLRQFTHXSSTY 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek6NP_001263151.1 leucine-rich repeat 71..96 CDD:275380 6/26 (23%)
LRR_8 96..155 CDD:290566 16/58 (28%)
leucine-rich repeat 97..120 CDD:275380 3/22 (14%)
leucine-rich repeat 121..144 CDD:275380 8/22 (36%)
LRR_4 144..186 CDD:289563 12/41 (29%)
leucine-rich repeat 145..168 CDD:275380 7/22 (32%)
leucine-rich repeat 169..216 CDD:275380 14/47 (30%)
LRRCT 225..274 CDD:214507 12/59 (20%)
Ig 295..367 CDD:143165 14/94 (15%)
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 5/17 (29%)
LRR_8 83..142 CDD:290566 18/63 (29%)
leucine-rich repeat 84..107 CDD:275380 5/27 (19%)
leucine-rich repeat 108..131 CDD:275380 8/22 (36%)
LRR_RI 129..421 CDD:238064 60/310 (19%)
LRR_8 132..190 CDD:290566 17/57 (30%)
leucine-rich repeat 132..155 CDD:275380 7/22 (32%)
leucine-rich repeat 156..179 CDD:275380 6/22 (27%)
leucine-rich repeat 180..204 CDD:275380 8/23 (35%)
LRR_8 203..263 CDD:290566 14/65 (22%)
leucine-rich repeat 205..228 CDD:275380 6/23 (26%)
leucine-rich repeat 229..252 CDD:275380 4/27 (15%)
LRR_8 252..308 CDD:290566 11/63 (17%)
leucine-rich repeat 253..276 CDD:275380 6/23 (26%)
leucine-rich repeat 277..300 CDD:275380 4/29 (14%)
leucine-rich repeat 301..322 CDD:275380 3/20 (15%)
LRR_8 325..384 CDD:290566 7/60 (12%)
leucine-rich repeat 326..350 CDD:275380 4/25 (16%)
leucine-rich repeat 351..373 CDD:275380 2/21 (10%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453522
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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