DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and CG42709

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001163434.1	Gene:	CG42709 / 39453	FlyBaseID:	FBgn0261674	Length:	458	Species:	Drosophila melanogaster

Alignment Length:	412	Identity:	89/412 - (21%)
Similarity:	154/412 - (37%)	Gaps:	96/412 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFSTLGLLNLQRIY 101
            ||..||.|  ....|...|::..||.:|..:.....::.|:.|.|..|..|:|:
  Fly    92 SCPRNCLC--LEDFKFVQCANAHLTHVPLDMPKTAAIIDLSHNVIAELRPEDFA----------- 143

  Fly   102 LKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPIL 166
                           ||...|||:|:.|.:..:|||.|.|::||:.|.|..|.|.::....|...
  Fly   144 ---------------NLSRAVEINLNHNLISSIDKDVFQGSERLKRLRLANNRLTKIDPDTFAAA 193

  Fly   167 PHLRTLDM-HDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCN 230
            ..|..||: ::.:...:|...|...:|:|| :..|.....|.|..||:|:.|:.|.|.:|.::..
  Fly   194 KELTLLDLSNNTITQRLDGSFLNQPDLVEF-SCVNCSWTELPEQTFQNMSGLEVLRLNKNDFKQQ 257

  Fly   231 CKLRKFRGWYVNSRLSSVSLVCKGPPAQKDRTWD------SVD------------DELFGCP--- 274
            ...:.|      |.|:.: :..|.|..::....:      |:|            :.:.|.|
  Fly   258 INTKAF------SPLTKI-IKLKLPELEQQNIEELCSLLTSIDTISFLNYDISCYEFVLGTPFNG 315

  Fly   275 -------PRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESESIASD 332
                   |.::...|..:    :.|.|:.:..|...|.|..:...|...:||...|.::..::|:
  Fly   316 SLIYPTEPPLKGITNPPI----VASITSTAKPVTATPAPPRSANRNRGKMDNSTELVKAGILSSE 376

  Fly   333 KLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMGIFGT 397
            ...|.::|               .....|.|..:.|....|         .|.....:::.:.|.
  Fly   377 TSTSGVSV---------------EPPAESQTNQVQISQEAI---------NTLLICIMVLAVIGI 417

  Fly   398 VFLLI---SISFVVCLCKRTTR 416
            |..||   .|..:...|.||::
  Fly   418 VIGLICRQDIGGIKTKCCRTSK 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:290566	17/58 (29%)
		leucine-rich repeat	97..120	CDD:275380	2/22 (9%)
		leucine-rich repeat	121..144	CDD:275380	10/22 (45%)
		LRR_4	144..186	CDD:289563	11/42 (26%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..216	CDD:275380	14/47 (30%)
		LRRCT	225..274	CDD:214507	9/66 (14%)
		Ig	295..367	CDD:143165	12/71 (17%)
CG42709	NP_001163434.1	LRR_8	126..182	CDD:290566	23/81 (28%)
		leucine-rich repeat	128..147	CDD:275380	8/44 (18%)
		leucine-rich repeat	148..171	CDD:275380	10/22 (45%)
		LRR_RI	<150..225	CDD:238064	24/75 (32%)
		LRR_8	171..254	CDD:290566	25/83 (30%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		leucine-rich repeat	220..243	CDD:275380	9/23 (39%)
		leucine-rich repeat	244..268	CDD:275380	7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930