DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek6 and Lrrc24

DIOPT Version :9

Sequence 1:NP_001263151.1 Gene:kek6 / 43729 FlyBaseID:FBgn0039862 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_932787.1 Gene:Lrrc24 / 378937 MGIID:3605040 Length:521 Species:Mus musculus


Alignment Length:466 Identity:121/466 - (25%)
Similarity:195/466 - (41%) Gaps:55/466 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 RTPRTLPVCWILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLV 75
            |.|..|.:...||.|.........:..|.:.|.|.    ..:..|.:|:|..:|..:....|.|.
Mouse     4 RAPTLLLLLLGLLLLPLLPGLPPRATGCPAACRCY----SATVECGALRLRVVPPGIPPGTQTLF 64

  Fly    76 LNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFM 140
            |.||.|.:|  |:.|...|..|:.:||..:.::.:...:||....|:|:.|:.|:|..|....|:
Mouse    65 LQDNSIAHL--EQGSLAPLAALRHLYLHNNTLRALESGAFRAQPRLLELALTGNRLRGLRGGAFV 127

  Fly   141 GNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLES 205
            |..:||:|||.||.|.:|..:.|..||.|:.|.:.:..|..::..:||.|:.|..|:|..|.|.:
Mouse   128 GLVQLRVLYLAGNQLAKLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGT 192

  Fly   206 LSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGW-------YVNSRLSSVSLVCKGPPAQKDRTW 263
            :|:...|.:::|:.|.|.||||:|:|.|.....|       .::||  ...:.|..||....::.
Mouse   193 ISKEALQPLSSLQVLRLTENPWRCDCALHWLGSWIKEGGRRLLSSR--DKKITCAEPPRLALQSL 255

  Fly   264 DSVDDELFGC-PPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWE-----LNGKILDNDNV 322
            ..|......| ||.|.:...|...|  :|.:...:|...|.|.|.|.|.     .:||......:
Mouse   256 LEVSGGSLICIPPSVNVEPPEFTAN--LGEDLQVACQASGYPQPLVVWRKVPQPRDGKPQAQAQL 318

  Fly   323 LFESESIAS----DKLWSNLTVFNVTSLDAGTYACTGSNSIGS------MTQNISIYLSEIV--- 374
            ...:..:..    |.....|.:.|:|...||.|.|..:|:.|.      :..|.|...|:.:   
Mouse   319 EGGAPGLGGHGTRDTGSGMLFLTNITLAHAGKYECEAANAGGKARVPFHLLVNASRQQSQQLPDP 383

  Fly   375 ------------QHVLEKTPETFWYFGLI--MGIFGTVFL--LISISFVVCLCKRTTRQHRHANK 423
                        ||  |.....|...||.  ..|...:.|  |.::.....:|:|..|:.:....
Mouse   384 QAPATRPVGHEPQH--EAGSMAFRALGLATQTAITAAIALLALTALLLAAMICRRRRRRKKVPAP 446

  Fly   424 AGVKSSVSFND 434
            :| :.::..||
Mouse   447 SG-EGTLFVND 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek6NP_001263151.1 leucine-rich repeat 71..96 CDD:275380 10/24 (42%)
LRR_8 96..155 CDD:290566 20/58 (34%)
leucine-rich repeat 97..120 CDD:275380 5/22 (23%)
leucine-rich repeat 121..144 CDD:275380 8/22 (36%)
LRR_4 144..186 CDD:289563 15/41 (37%)
leucine-rich repeat 145..168 CDD:275380 11/22 (50%)
leucine-rich repeat 169..216 CDD:275380 13/46 (28%)
LRRCT 225..274 CDD:214507 14/56 (25%)
Ig 295..367 CDD:143165 19/86 (22%)
Lrrc24NP_932787.1 LRR_8 48..92 CDD:290566 15/45 (33%)
LRR 1 59..80 9/22 (41%)
LRR_RI <60..>166 CDD:238064 37/107 (35%)
leucine-rich repeat 61..83 CDD:275380 10/23 (43%)
LRR 2 83..104 4/20 (20%)
LRR_8 84..142 CDD:290566 20/57 (35%)
leucine-rich repeat 84..107 CDD:275380 5/22 (23%)
LRR 3 107..128 7/20 (35%)
leucine-rich repeat 108..131 CDD:275380 8/22 (36%)
LRR_8 131..213 CDD:290566 29/81 (36%)
LRR_4 131..171 CDD:289563 15/39 (38%)
LRR 4 131..152 10/20 (50%)
leucine-rich repeat 132..155 CDD:275380 11/22 (50%)
LRR 5 155..176 4/20 (20%)
leucine-rich repeat 156..179 CDD:275380 6/22 (27%)
LRR 6 179..200 6/20 (30%)
leucine-rich repeat 180..203 CDD:275380 7/22 (32%)
LRRCT 212..265 CDD:214507 13/54 (24%)
Ig 267..361 CDD:299845 23/95 (24%)
IG_like 274..370 CDD:214653 21/97 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 306..330 2/23 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 374..395 1/20 (5%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
32.870

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