DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and 18w

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	146/780 - (18%)
Similarity:	253/780 - (32%)	Gaps:	306/780 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SRTPRTLPVCWILLCLVAWTVADDWSLSCASNCTC----KW-TNGKKSAICSSLQLTTIPNTLST 69
            |..|.|...|....|        :..:.|..||:|    .| ||   ...|....|..:||.:..
  Fly   739 SHCPPTCHCCEYEQC--------ECEVICPGNCSCFHDATWATN---IVDCGRQDLAALPNRIPQ 792

  Fly    70 ELQVLVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEML 134
            ::..|.|:.|::|.|  |.....|..||:.:||..|.:..:...|...|.
  Fly   793 DVSDLYLDGNNMPEL--EVGHLTGRRNLRALYLNASNLMTLQNGSLAQLV--------------- 840

  Fly   135 DKDTFMGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLK 199
                     .||:|:|..|.|..|...:|..|..||.|.:|:.::::|...:...|..||.|.|.
  Fly   841 ---------NLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLD 896

  Fly   200 NNLLESLSEYVFQHMANLKTLSLEENPWQCNC-KLRKFRGWYVNSRLSSVSLVCKGPPAQKDRTW 263
            ||.|.||....::|  :|:.|:|..|.|.|.| :||:...:     :|..::|.:
  Fly   897 NNRLSSLPHLQYRH--SLQGLTLGRNAWSCRCQQLRELAQF-----VSDNAMVVR---------- 944

  Fly   264 DSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESES 328
                             :..::..:|.|.....              ||.|.:.:..:
  Fly   945 -----------------DAHDIYCLDAGIKREL--------------ELIGNLANGPD------- 971

  Fly   329 IASDKLWSNLTVFNVTSLD--AGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLI 391
             .||.|  :.:..|::|..  ||.|                            :.|       |:
  Fly   972 -CSDLL--DASASNISSSQDLAGGY----------------------------RLP-------LL 998

  Fly   392 MGIFGTVFLLISISFVVCLCKRTTRQHRHANKAGVKSSVSFNDQEKKLLDSSVTTTTNDRGDSYG 456
            ..:...:||:: :..:|.:.:.:.|....|:                                ||
  Fly   999 AAVLVLIFLVV-VLIIVFVFRESVRMWLFAH--------------------------------YG 1030

  Fly   457 IDNQPTSIGMNKGDSAGMGFNQIEIHAVESH-----------RHG----SMLVQQQ---PQQ--- 500
            :     .:...:.:.||..::.|.:|:.:.:           .||    .:.:||:   ||.
  Fly  1031 V-----RVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHL 1090

  Fly   501 QQVAGG--------------------------------GGMRQQLMQVKDS-------------- 519
            |.|.|.                                .|:.|:|:.::::
  Fly  1091 QLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSP 1155

  Fly   520 -----------TCG-------MMSVPTSMAGHAHSHPAQISEEF--PLNVGVF-----PPPPEFC 559
                       ||.       ..::|..::...:::.....|.|  |::.|:.     |||..:|
  Fly  1156 YLKSVPSNRLLTCDRYFWEKLRYAIPIELSPRGNNYTLDHHERFKQPVSPGMIFRQAPPPPAYYC 1220

  Fly   560 SNIV-------------PNPAFGGNIFIRVSVTQDMLDGADLNMYPDLLNIPKRMQDVQESGAGA 611
            :..:             |.|...|.       ...::|...:.|.|...:|...:
  Fly  1221 TEEMEANYSSATTATPSPRPTRPGG-------AARIVDSMPMPMRPPSEHIYHSI---------- 1268

  Fly   612 VAVPEGQFATLPRHTARRGILKKDTSLQQQQQQHQ-QQHQHQQQQQQQQIQQQQHQQLQQQHQPS 675
                |.:::...:|.|...|   .|.|..|.||.| :.||.|||||||::.|.|.:.:.||..|:
  Fly  1269 ----ESEYSAYDQHEALSMI---PTGLMHQHQQQQLRLHQQQQQQQQQRLLQPQFRAMPQQAIPA 1326

Fly 676 675
Fly 1327 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:290566	12/58 (21%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	0/22 (0%)
		LRR_4	144..186	CDD:289563	14/41 (34%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		leucine-rich repeat	169..216	CDD:275380	16/46 (35%)
		LRRCT	225..274	CDD:214507	8/49 (16%)
		Ig	295..367	CDD:143165	11/73 (15%)
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064
		leucine-rich repeat	212..236	CDD:275380
		LRR_8	235..295	CDD:290566
		leucine-rich repeat	237..260	CDD:275380
		leucine-rich repeat	261..284	CDD:275380
		LRR_8	283..345	CDD:290566
		leucine-rich repeat	285..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		LRR_8	334..393	CDD:290566
		leucine-rich repeat	335..358	CDD:275380
		leucine-rich repeat	359..382	CDD:275380
		LRR_8	382..441	CDD:290566
		leucine-rich repeat	383..406	CDD:275380
		leucine-rich repeat	407..430	CDD:275380
		LRR_8	431..488	CDD:290566
		leucine-rich repeat	431..451	CDD:275380
		leucine-rich repeat	454..477	CDD:275380
		LRR_8	477..559	CDD:290566
		leucine-rich repeat	478..499	CDD:275380
		leucine-rich repeat	502..525	CDD:275380
		leucine-rich repeat	526..548	CDD:275380
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380	4/20 (20%)
		LRR_8	797..852	CDD:290566	19/80 (24%)
		leucine-rich repeat	797..817	CDD:275380	7/21 (33%)
		leucine-rich repeat	818..841	CDD:275380	6/46 (13%)
		LRR_8	841..900	CDD:290566	21/58 (36%)
		leucine-rich repeat	842..865	CDD:275380	9/22 (41%)
		LRR_4	866..907	CDD:289563	15/40 (38%)
		leucine-rich repeat	866..889	CDD:275380	6/22 (27%)
		leucine-rich repeat	890..911	CDD:275380	10/22 (45%)
		TIR	1045..1183	CDD:214587	17/137 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930