DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and swi2

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_611247.3	Gene:	swi2 / 37010	FlyBaseID:	FBgn0034262	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	296	Identity:	65/296 - (21%)
Similarity:	99/296 - (33%)	Gaps:	123/296 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NCTC-------KWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFSTLGLLNLQ 98
            ||||       |......:..||.||...:|:.|......||:|||.|..:|.
  Fly   271 NCTCLMHHILPKTHIPLYTVNCSHLQFHRLPDFLPDNTTTLVINDNMISDINP------------ 323

  Fly    99 RIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLD--KDTFMGNDRLRILYLNGNPLKRLAAY 161
                .:....|.|         :|::.|.:|::..:|  :||:. ....|:|.|.||.|::|
  Fly   324 ----LRDNPHYRH---------VVDMQLENNQISNVDNLEDTYW-LQNFRLLNLRGNNLRKL--- 371

  Fly   162 QFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENP 226
                  |:..||      :.:|....|||                             |.|..||
  Fly   372 ------HVYALD------NALDDNENANL-----------------------------LLLSRNP 395

  Fly   227 WQCNCK--------LRKFR-----GWYVNSRLSSVSLVCKGPPAQKDRTWDSVDDELFGCPPRVE 278
            |.|.||        |.|::     .|.|:         |         |:...||:|..   :|.
  Fly   396 WHCTCKFGSRMRELLTKYKDIVRDAWNVS---------C---------TYRLDDDQLLA---KVL 439

  Fly   279 IFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNG 314
            ..:.:|:.|:.:..         |..:..:.| |||
  Fly   440 TLSRQEMCNLSVEG---------GTQIHPIDW-LNG 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:290566	13/60 (22%)
		leucine-rich repeat	97..120	CDD:275380	2/22 (9%)
		leucine-rich repeat	121..144	CDD:275380	6/24 (25%)
		LRR_4	144..186	CDD:289563	11/41 (27%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		leucine-rich repeat	169..216	CDD:275380	6/46 (13%)
		LRRCT	225..274	CDD:214507	15/61 (25%)
		Ig	295..367	CDD:143165	5/20 (25%)
swi2	NP_611247.3	LRR	<117..384	CDD:227223	37/153 (24%)
		leucine-rich repeat	132..154	CDD:275378
		leucine-rich repeat	155..178	CDD:275378
		leucine-rich repeat	179..201	CDD:275378
		leucine-rich repeat	202..214	CDD:275378
		leucine-rich repeat	287..307	CDD:275378	6/19 (32%)
		leucine-rich repeat	308..332	CDD:275378	8/39 (21%)
		leucine-rich repeat	333..357	CDD:275378	6/24 (25%)
		leucine-rich repeat	358..385	CDD:275378	11/41 (27%)
		leucine-rich repeat	386..398	CDD:275378	8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100