DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and Lrfn1

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001121166.1	Gene:	Lrfn1 / 365222	RGDID:	1304707	Length:	766	Species:	Rattus norvegicus

Alignment Length:	406	Identity:	92/406 - (22%)
Similarity:	152/406 - (37%)	Gaps:	79/406 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SRTPRTLPVCWILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVL 74
            |..|..||     ..|:.|..|.. ...|...|.|:......:.:|:...|..:|..:...:..|
  Rat    12 SPPPAALP-----FLLLLWAGASR-GQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVEL 70

  Fly    75 VLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTF 139
            .|.||.|..:.|.:|:  .:.:|..:.|.::.:..:...:|.:|:.|..:.|..|:|..:..|..
  Rat    71 RLTDNFIAAVRRRDFA--NMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQL 133

  Fly   140 MGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNL------------ 192
            .|...||.|.|..|.::::.:..|            |..:|.::.:.|:..||
  Rat   134 RGLGNLRHLILGNNQIRKVESAAF------------DAFLSTVEDLDLSYNNLEALPWEAVGQMV 186

  Fly   193 -LEFLNLKNNLLESLSEYVFQHMANL--------------------------------KTLSLEE 224
             |..|.|.:||::.::|..|..:..|                                .|:|...
  Rat   187 NLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGGGPKPPTPLTVSFGG 251

  Fly   225 NPWQCNCKLRKFRGWYVNSRLSSVSLVCKGPPAQKDRTWDSVDDELFGC-PPRVEIFNNEEVQNI 288
            ||..|||:|...|.......|.:    |..|....||.:.|:.:|.|.| ||.:..........:
  Rat   252 NPLHCNCELLWLRRLTREDDLET----CATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVV 312

  Fly   289 DIGSNTTFSCLVYGDPLPEVAWEL-NGKILDNDNVLFESESIASDKLWSNLTVFNVTSLDAGTYA 352
            : |...:..|...|||.|.|.|.. :|::|.|.:    ...:..|   ..|.|...|..|:||:.
  Rat   313 E-GQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSS----RTRVRGD---GTLDVTITTLRDSGTFT 369

  Fly   353 CTGSNSIGSMTQNISI 368
            |..||:.|..|..:.:
  Rat   370 CIASNAAGEATAPVEV 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:290566	15/58 (26%)
		leucine-rich repeat	97..120	CDD:275380	4/22 (18%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	8/41 (20%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..216	CDD:275380	12/59 (20%)
		LRRCT	225..274	CDD:214507	16/49 (33%)
		Ig	295..367	CDD:143165	22/72 (31%)
Lrfn1	NP_001121166.1	LRR 1	66..87		7/22 (32%)
		leucine-rich repeat	67..90	CDD:275380	7/24 (29%)
		PPP1R42	70..226	CDD:411060	36/169 (21%)
		LRR 2	90..111		3/20 (15%)
		leucine-rich repeat	91..114	CDD:275380	4/22 (18%)
		LRR 3	114..135		5/20 (25%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR 4	138..159		6/32 (19%)
		leucine-rich repeat	139..163	CDD:275380	7/35 (20%)
		LRR 5	163..184		3/20 (15%)
		leucine-rich repeat	164..187	CDD:275380	3/22 (14%)
		LRR 6	187..208		7/20 (35%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		LRR 7	211..232		1/20 (5%)
		leucine-rich repeat	212..230	CDD:275380	1/17 (6%)
		LRRCT	252..>284	CDD:214507	10/35 (29%)
		Ig	299..387	CDD:416386	24/95 (25%)
		Ig strand A	299..302	CDD:409353	1/2 (50%)
		Ig strand A'	306..310	CDD:409353	0/3 (0%)
		Ig strand B	316..324	CDD:409353	1/7 (14%)
		Ig strand C	330..335	CDD:409353	2/4 (50%)
		Ig strand C'	338..340	CDD:409353	1/1 (100%)
		Ig strand D	346..350	CDD:409353	0/3 (0%)
		Ig strand E	353..357	CDD:409353	1/3 (33%)
		Ig strand F	367..374	CDD:409353	2/6 (33%)
		Ig strand G	377..387	CDD:409353	2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422
		FN3	426..500	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..601
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..742
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910