DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and kek3

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster

Alignment Length:	959	Identity:	236/959 - (24%)
Similarity:	359/959 - (37%)	Gaps:	212/959 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RSRTPRTLP-VCWILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQ 72
            |.|.|..|. :.|:|.|.   :........|.:.|.|||.:||:|.:|.:..||.||..|....|
  Fly    52 RPRLPLHLHLLLWLLCCC---SQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQ 113

  Fly    73 VLVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKD 137
            :|.|:.|.|..:..:.|:|..|||||::||.:..::.|.:.:||.|..|||:|||.|.|..:...
  Fly   114 LLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSL 178

  Fly   138 TFMGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANL-NLLEFLNLKNN 201
            .......||.|.|:|||:.|:....|..:|.|..|::.||.:|:|...:.|.| :.||:|.|..|
  Fly   179 ALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGN 243

  Fly   202 LLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRL-SSVSLVCKGPPAQKDRTWDS 265
            .|..:.......:|:|..|.|..|.|.|:|.||..|.|.:...: |.:...|:.||....|.||.
  Fly   244 RLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDK 308

  Fly   266 VDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKIL---------DNDN 321
            :|.:.|.|.|:: :..:.....:: |.|.|.||.|.|.|.|.|.|.|..:::         |:|:
  Fly   309 LDVDDFACVPQI-VATDTTAHGVE-GRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDS 371

  Fly   322 VLFESESIASDKLW--------SNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVL 378
            ....:.:....|.:        ||||:......|||.|.|...|..|.:..::::.:|
  Fly   372 EPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVS------- 429

  Fly   379 EKTPETFWYFGLI-MGIFGTVFLLISISF-VVCLCKRTTRQHRH--------------------- 420
            .:.||..|...:| :|....:.|:...|| .:|||....|:...
  Fly   430 RRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTA 494

  Fly   421 ----------------ANKAGVKSSVSFNDQEKK--LLDSSVTTTTNDRGDSYGIDNQPT-SIGM 466
                            |..||:     |:|.|::  |..:......||.|.:..|.|... |...
  Fly   495 RTRPDLGGGASCGGGSATGAGL-----FHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGSAQR 554

  Fly   467 NKGDSAGMGFN--------QIEIH-----AVESHRHGSMLVQQQPQQQQ------VAGGGGMRQQ 512
            ..||...:..:        |:..|     |.:.|.|.:   |||.||::      |:..|.....
  Fly   555 RNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPN---QQQHQQRKGSQGHVVSASGANNSA 616

  Fly   513 LMQVKD-----------------STCGMMSVPTSMAGHA-----------------HSHPAQISE 543
            .::..|                 |....:.....:||:|                 ||.|...:.
  Fly   617 PLEETDLHIPRLIDIGGTDSASSSISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSKPVTSAA 681

  Fly   544 EFPLNVGVFP-------PPPEFCSNIVPNPAFGGNIFIRVSVTQDMLDGADLNMYPDLLNIPK-R 600
            ...||....|       |..|..:          ::|.......|:.|    :.|||||:|.| .
  Fly   682 PSSLNTQATPYAHYGNHPADEMAT----------SVFCSEGQESDLFD----SNYPDLLDIAKYA 732

  Fly   601 MQDVQESGAG-----AVAVPEGQFATLPRHTARRGILKKDTSLQQQQQQHQQQHQHQQQQQQQQI 660
            :...|:.|.|     |...|.|...||||.....|...:::|..|.........::.........
  Fly   733 VAQAQQEGRGQGYAQATTTPNGGLCTLPRKLKTSGKYFRNSSDSQSPLLADNSSKYGSSTLGDGS 797

  Fly   661 QQQQHQQLQQQHQPSGLY-THDEIVTY---NLEASGY-DPHQSGYHSNAMELPPPPPPPAVTAVV 720
            ...:...|.:::.....| .:....||   ...|:.: :..|||.|...: ||
  Fly   798 FLNEAMGLGRRYSAESSYANYSSTATYTGGGQRANSFLNLVQSGAHQGKL-LP------------ 849

  Fly   721 QCHHPSPNNCASCINNAPPPPSACQSPPVEVTPMRPLDSSAYPKYDNMGRRITASGGLGGSNLSL 785
                       |.:...|..||   ||   |...|.|.|:|.|..|...   .||...|.:|.|:
  Fly   850 -----------SHLGQKPSLPS---SP---VQHQRSLSSAATPLLDFSA---LASRAAGAANTSV 894

  Fly   786 --HDE-----ERYENETLFGQAESQTKGMPEQSQDLHQ---PQEVTQGQ 824
              :|.     ||:..|  :...:.|...|.|....:.:   |..|..||
  Fly   895 AAYDYHAAQLERFLEE--YRNLQDQLCKMKETCDTIRKKETPLRVAIGQ 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/24 (33%)
		LRR_8	96..155	CDD:290566	23/58 (40%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_4	144..186	CDD:289563	16/41 (39%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		leucine-rich repeat	169..216	CDD:275380	14/47 (30%)
		LRRCT	225..274	CDD:214507	17/49 (35%)
		Ig	295..367	CDD:143165	24/88 (27%)
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	54/156 (35%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	23/58 (40%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	23/60 (38%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	17/48 (35%)
		IG_like	328..428	CDD:214653	26/100 (26%)
		Ig	335..425	CDD:143165	24/89 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.060