DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and LINGO4

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001004432.1	Gene:	LINGO4 / 339398	HGNCID:	31814	Length:	593	Species:	Homo sapiens

Alignment Length:	550	Identity:	111/550 - (20%)
Similarity:	179/550 - (32%)	Gaps:	204/550 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFSTLGLLNLQRIY 101
            ||.:.|.|  |:..::.:|...||..:|..|..:.::|.|:.|.:..|.:...|.|.|  ||.:.
Human    30 SCPAVCDC--TSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSL--LQELD 90

  Fly   102 LKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLR---------ILYLNG----- 152
            |..:::..:...:|..|:.|:.:.|..|:|.::....|.|...|.         :|:|:|
Human    91 LSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGEL 155

  Fly   153 ----------NPLKRLAAYQFPILPHLRTLDMHDCLISYI------------------------- 182
                      |.|..:|...|..|..|.||.:..|.:|.:
Human   156 GSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLP 220

  Fly   183 ------------------------DPMSLANLNL--------------------LEF-------- 195
                                    ||.||..|||                    |.|
Human   221 AGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQ 285

  Fly   196 -------------------------------------------LNLKNNLLESLSEYVFQHMANL 217
                                                       |::.:|.|::|.|..|.....|
Human   286 NPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKL 350

  Fly   218 KTLSLEENPWQCNCKLRKFRGWYVNSR----LSSVSLVCKGPPAQKDRTWDSVDDEL----FGCP 274
            .||.|..||..|:|:|.    |.:..|    .......|.||...:.::.....|.|    |.|.
Human   351 VTLRLSGNPLTCDCRLL----WLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCK 411

  Fly   275 PRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAW-ELNG---------KILDNDNVLFESESI 329
            |.:...:.......:.|.:..|||...|||.|.|:| ..:|         ::|::
Human   412 PALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLED---------- 466

  Fly   330 ASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGL-IMG 393
                  ..|.:.:|...|.|.|.|..||..|:  .::..:| |::|  :|....|.....: :.|
Human   467 ------GTLEIRSVQLRDRGAYVCVVSNVAGN--DSLRTWL-EVIQ--VEPPNGTLSDPNITVPG 520

  Fly   394 IFGTVFL-------LISISFV-----VCLC 411
            |.|..||       ::::.|:     |.||
Human   521 IPGPFFLDSRGVAMVLAVGFLPFLTSVTLC 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:290566	16/82 (20%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	16/114 (14%)
		leucine-rich repeat	145..168	CDD:275380	9/46 (20%)
		leucine-rich repeat	169..216	CDD:275380	20/166 (12%)
		LRRCT	225..274	CDD:214507	13/56 (23%)
		Ig	295..367	CDD:143165	20/81 (25%)
LINGO4	NP_001004432.1	LRRNT	31..64	CDD:214470	9/34 (26%)
		leucine-rich repeat	62..85	CDD:275380	6/22 (27%)
		LRR_8	65..120	CDD:290566	15/56 (27%)
		leucine-rich repeat	86..109	CDD:275380	5/22 (23%)
		LRR_RI	87..320	CDD:238064	33/232 (14%)
		LRR_8	109..168	CDD:290566	11/58 (19%)
		leucine-rich repeat	110..133	CDD:275380	6/22 (27%)
		leucine-rich repeat	134..157	CDD:275380	4/22 (18%)
		LRR_8	157..212	CDD:290566	10/54 (19%)
		leucine-rich repeat	158..181	CDD:275380	5/22 (23%)
		leucine-rich repeat	182..205	CDD:275380	5/22 (23%)
		leucine-rich repeat	206..229	CDD:275380	0/22 (0%)
		leucine-rich repeat	230..277	CDD:275380	8/46 (17%)
		LRR_8	253..309	CDD:290566	4/55 (7%)
		leucine-rich repeat	278..301	CDD:275380	0/22 (0%)
		LRR_8	301..360	CDD:290566	11/58 (19%)
		leucine-rich repeat	302..325	CDD:275380	0/22 (0%)
		leucine-rich repeat	326..344	CDD:275380	5/17 (29%)
		leucine-rich repeat	350..362	CDD:275378	6/11 (55%)
		IG_like	420..501	CDD:214653	22/99 (22%)
		Ig	431..501	CDD:299845	21/88 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910