DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and kek5

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	934	Identity:	239/934 - (25%)
Similarity:	362/934 - (38%)	Gaps:	221/934 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MDRRRSRTPRTLPVCWILLCLVAWTVA--------DDWSLSCASNCTCKWTNGKKSAICSSLQLT 61
            |..|..|:.|.|.:..:||.::...:|        .||..||.: |.|:|.:|||||.|.:..||
  Fly     2 MGNRTERSGRRLGMILLLLGVLVVLMALPPPTAGTTDWMQSCGT-CHCQWNSGKKSADCKNKALT 65

  Fly    62 TIPNTLSTELQVLVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDL 126
            .||..:|.|:|||....|.||.|.||||...||.|:.:|:|:...:|.:|:|:|:.|.||:|:||
  Fly    66 KIPQDMSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDL 130

  Fly   127 SDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLN 191
            |.|::..|...||.|.::||.:.:|.|.::.|..:.|..|..|..::..:..:..:.....|...
  Fly   131 SGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTM 195

  Fly   192 LLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSLVCKGPP 256
            .|..::|:.|.|..|.:..|:.:..|..|||:.|.|.|:|:|:.||.:.::.||.:....|:.||
  Fly   196 ALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRDFAISKRLYTPPTDCQEPP 260

  Fly   257 AQKDRTWDSVDDELFGCPPRVEIFNNEEVQNIDIGS----------NTTFSCLVYGDPLPEVAWE 311
            ..:.:.|..|..|.|.|.||:            :||          |.:..|.:.|.|.|.|.|.
  Fly   261 QLRGKLWSEVPSENFACRPRI------------LGSVRSFIEANHDNISLPCRIVGSPRPNVTWV 313

  Fly   312 LNGKILDNDN----VLFESESI---ASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIY 369
            .|.:.|...:    ||...|.:   .|..|.|.|.:..|.:.|.|.|.|...|..|.......:.
  Fly   314 YNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLL 378

  Fly   370 LSEIVQHVLEKT--------------PETFWYFGLIMGIFGTVFLLISISFVVCL---CKRTTRQ 417
            :|......:..:              |:|..:  ||:.:..|..||:.:..|:.|   |:|....
  Fly   379 VSGDYAGAVSASDGMGMGAIGAPTIDPQTNMF--LIICLIITTLLLLLLVAVLTLFWYCRRIKTY 441

  Fly   418 HRHANKAGVKSSVSFNDQEKKLLDSSVTTTTNDRGDSYGIDNQPTSIGMNKGDSAGMGFNQIEIH 482
            .:                          .||...||..      .|..|:|..:..|....:.:.
  Fly   442 QK--------------------------DTTMMSGDGL------ISSKMDKTHNGSMLEGSVIME 474

  Fly   483 AVESHRHGSMLVQQQPQQ---QQVAGGGGMRQQLMQVKDSTCGMMSVPTSMAGHAHSHPAQISEE 544
            ..:|..:....|::.|::   :.|.||    ..::::|.:   ::.....:|.|:.       :|
  Fly   475 MQKSLLNEVNPVEKPPRRTDIESVDGG----DDVLEIKKT---LLDDTVYVANHSR-------DE 525

  Fly   545 FPLNVGVFPPPPEFCSNIVPNPAFGGNIFIRVSVTQDMLDGADLN-MYPDLLNIPKR-------M 601
            ..::|.:        |:....|          ......:|.|..| :.||||..|.|       |
  Fly   526 EAVSVAM--------SDTTTTP----------RSRHTYVDDAYANSLPPDLLAFPARVPPTSPSM 572

  Fly   602 QDVQES-----------------------------GAGAVAVPEGQFATLPRHTARRGILKKDTS 637
            |..|.:                             |...:..|...|.||....:|...|...|:
  Fly   573 QSSQSNIPDQVIYGIRSPPSLTSPVYTHMTPHGIYGTKTMTAPHNGFMTLQHPKSRNLALIATTN 637

  Fly   638 LQQQQQQH-----QQQHQHQQQQQQQQIQQQQHQQLQQQHQPSGLYTHDEI----VTYNLEASGY 693
            ..:|.|.|     ||||.|..||||||.|||||.          |.|....    |.|: .|:|.
  Fly   638 SSRQHQHHHQLQQQQQHHHHHQQQQQQQQQQQHP----------LATTSPFLPAPVVYS-PATGV 691

  Fly   694 DPHQSGYHSNAMELPPPPPPPAVTAVVQCHHPSPNNCASCINNAPPPPSACQSP----PVEVTPM 754
            ...| ||    |.:|..|..|:..       ||.:..|   .:.....|..|||    |.|....
  Fly   692 VMKQ-GY----MTIPRKPRAPSWA-------PSTSGAA---GHGSIQLSEFQSPTSPNPSETGTA 741

  Fly   755 RPLDSSAYPKYDNMGRRITASG-------------GLGGSNLSLHDEERYENETL--FGQAESQT 804
            ...:..|.|.|||:|.|.||.|             |..|...|:.|.......:|  ...|.:.:
  Fly   742 TTAELQAEPVYDNLGLRTTAGGNSTLNLTKIAGSQGGAGQQYSMRDRPLPATPSLTSVSSATNAS 806

  Fly   805 K------GMPEQSQDLHQPQEVTQ 822
            |      .:.:|.|.|.|.|:..|
  Fly   807 KIYEPIHELIQQQQQLQQQQQQQQ 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	13/24 (54%)
		LRR_8	96..155	CDD:290566	23/58 (40%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	10/22 (45%)
		LRR_4	144..186	CDD:289563	8/41 (20%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		leucine-rich repeat	169..216	CDD:275380	8/46 (17%)
		LRRCT	225..274	CDD:214507	16/48 (33%)
		Ig	295..367	CDD:143165	22/78 (28%)
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	36/83 (43%)
		leucine-rich repeat	76..100	CDD:275380	13/23 (57%)
		LRR_8	99..159	CDD:290566	23/59 (39%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR	122..145	CDD:197688	11/22 (50%)
		leucine-rich repeat	125..148	CDD:275380	10/22 (45%)
		LRR_8	148..207	CDD:290566	12/58 (21%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	2/22 (9%)
		LRR_8	197..>229	CDD:290566	10/31 (32%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		LRRCT	229..277	CDD:214507	16/47 (34%)
		Ig	296..376	CDD:143165	22/79 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452937
Domainoid	1	1.000	43	1.000	Domainoid score	I12360
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4399
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.890