DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek6 and Amigo3

DIOPT Version :9

Sequence 1:NP_001263151.1 Gene:kek6 / 43729 FlyBaseID:FBgn0039862 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_835280.1 Gene:Amigo3 / 316003 RGDID:631413 Length:508 Species:Rattus norvegicus


Alignment Length:497 Identity:107/497 - (21%)
Similarity:168/497 - (33%) Gaps:146/497 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 SCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFSTLGLLNLQRIY 101
            :|.:.|.|    ......|:...|..:|..|.                     :|...|:|....
  Rat    33 NCPNKCVC----AADVLSCAGRGLQDLPAALP---------------------ATAAELDLSHNA 72

  Fly   102 LKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPIL 166
            ||:     :|......|..|..:.|..|||::|.:..|.....||||.|:.|.|:||..|....|
  Rat    73 LKR-----LHPGWLAPLSRLRALYLGYNKLDVLGRGVFTNASGLRILDLSSNLLRRLRTYDLDGL 132

  Fly   167 PHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQH-----MANLKTLS----- 221
            ..|..|.:.:..:.::|..:...|::|..|.|..|   .||.:.|.|     :..|:||.     
  Rat   133 EELEKLLLFNNRLMHLDLDAFQGLSMLSHLYLSCN---ELSSFSFNHLHGLGLTRLRTLDLSSNW 194

  Fly   222 ---------------------LEENPWQCNCKL-RKFRGWYVNSRLSSV-----SLVCKGPPAQK 259
                                 |..||..|:|.| ...|.|:... ||::     ...|......:
  Rat   195 LGHVSVPELAALPTFLKNRLYLHNNPLPCDCSLYHLLRRWHQRG-LSALHDFEREYTCLAFKVAE 258

  Fly   260 DRTWDSVDDELF-----GCPPRVEIFNNEEV-----QNIDIGSNTTFSCLVYGDPLPEVAWELNG 314
            .|........:|     ...|.:|: ..||:     |::.:..|||.       |...|||    
  Rat   259 SRVRFFEHSRVFKNCSVAAAPGLEL-PEEELHTHVGQSLRLFCNTTV-------PAARVAW---- 311

  Fly   315 KILDNDNVLFE------SESIASDKLWSNLTVFNVTSLDAGTYACTGS----NSIGSMTQNISIY 369
             :...:.:|..      |.::.:|   .:|.:..|....||.:.|..|    :...::..|:|: 
  Rat   312 -VSPKNELLVAPGSQDGSIAVLAD---GSLAIGRVQEQHAGLFVCLASGPRLHHNQTLEYNVSV- 371

  Fly   370 LSEIVQHVLEKTPETF-WYFGLIMG-IFGTVFLLISISFVVC-----LCKR-------------- 413
                  |.....||.| ..|..::| |.|.|.:|:.:....|     .|:|              
  Rat   372 ------HKPRPEPEAFNTGFTTLLGCIVGLVLVLLYLFAPPCRGCCRCCRRACRNRCWPRASSPL 430

  Fly   414 -----------TTRQHRHANKAGVKSSVSFNDQEKKLLDSSV 444
                       ||.....:.||.|...|:|.:..||.|:..|
  Rat   431 QELSAQSSVLSTTPPDAPSRKASVHKHVAFLEPGKKGLNGRV 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek6NP_001263151.1 leucine-rich repeat 71..96 CDD:275380 1/24 (4%)
LRR_8 96..155 CDD:290566 18/58 (31%)
leucine-rich repeat 97..120 CDD:275380 5/22 (23%)
leucine-rich repeat 121..144 CDD:275380 7/22 (32%)
LRR_4 144..186 CDD:289563 14/41 (34%)
leucine-rich repeat 145..168 CDD:275380 11/22 (50%)
leucine-rich repeat 169..216 CDD:275380 12/51 (24%)
LRRCT 225..274 CDD:214507 12/59 (20%)
Ig 295..367 CDD:143165 15/81 (19%)
Amigo3NP_835280.1 LRR 1 62..83 6/25 (24%)
LRR_8 65..121 CDD:404697 19/60 (32%)
leucine-rich repeat 65..86 CDD:275380 6/25 (24%)
LRR 2 86..107 7/20 (35%)
leucine-rich repeat 87..110 CDD:275380 7/22 (32%)
LRR 3 110..131 10/20 (50%)
leucine-rich repeat 111..134 CDD:275380 11/22 (50%)
LRR 4 134..155 3/20 (15%)
leucine-rich repeat 135..158 CDD:275380 4/22 (18%)
LRR_8 142..193 CDD:404697 13/53 (25%)
LRR 5 158..178 8/22 (36%)
leucine-rich repeat 159..184 CDD:275380 8/27 (30%)
LRR 6 184..207 3/22 (14%)
leucine-rich repeat 185..208 CDD:275380 3/22 (14%)
Ig_3 279..355 CDD:404760 20/91 (22%)
Ig strand B 295..303 CDD:409353 1/7 (14%)
Ig strand C 308..313 CDD:409353 3/9 (33%)
Ig strand C' 316..318 CDD:409353 0/1 (0%)
Ig strand D 329..332 CDD:409353 0/2 (0%)
Ig strand E 335..342 CDD:409353 1/6 (17%)
Ig strand F 348..355 CDD:409353 2/6 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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