DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and Lingo1

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001094192.1	Gene:	Lingo1 / 315691	RGDID:	1308668	Length:	620	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	131/598 - (21%)
Similarity:	200/598 - (33%)	Gaps:	224/598 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSMDRRRSRTPRTLPVCW-ILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNT 66
            |||       |..|..|| .:|.||..:|....:..|...|.|...:  ::.:|...:...:|..
  Rat    13 RSM-------PSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQD--RAVLCHRKRFVAVPEG 68

  Fly    67 LSTELQVLVLNDNHIPYLNREEFSTL----------------------GLLNLQRIYLKKSEVQY 109
            :.||.::|.|..|.|..||::||::.                      .|.||:.:.|:.:.::.
  Rat    69 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKL 133

  Fly   110 IHKESFRNLKILVEIDLSDNK-----------------LEMLDKD-------TFMGNDR------ 144
            |....|..|..|.::|:|:||                 ||:.|.|       .|.|.:.
  Rat   134 IPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTL 198

  Fly   145 ---------------------LRILYLNGNPL-----KRLAAYQFPIL-----PHLRTLD----- 173
                                 ||:.:||.|.:     |||  |:..:|     |:|.|:.
  Rat   199 EKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRL--YRLKVLEISHWPYLDTMTPNCLY 261

  Fly   174 ---------------------------------------------MHDCL-----------ISYI 182
                                                         :|:.|           ::.:
  Rat   262 GLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVV 326

  Fly   183 DPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKF--RGWYVNSRL 245
            :|.:...||.|..||:..|.|.:|.|..|..:.||:||.|:.||..|:|:|...  |.|.:|  .
  Rat   327 EPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLN--F 389

  Fly   246 SSVSLVCKGPPAQKDRTWDSVDDEL----FGCPPRVEIFNNEEVQ-NIDIGSNTTFSCLVYGDPL 305
            :.....|..|...:.:.:....|.|    |.| .|..|.:.:..| .:|.|....|.|...|||.
  Rat   390 NRQQPTCATPEFVQGKEFKDFPDVLLPNYFTC-RRAHIRDRKAQQVFVDEGHTVQFVCRADGDPP 453

  Fly   306 PEVAWELNGKILDNDNVLFESESIASDKLWSNLTVFNVTSL--------DAGTYACTGSNSIG-- 360
            |.:.|            |...:.:.|.|....||||...:|        |.|||.|..:|:.|
  Rat   454 PAILW------------LSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGND 506

  Fly   361 SMTQNISIYLSEIVQHVLEKTPE-------TFWY--------------------FGLIMGIFGTV 398
            ||..::         ||...:|:       ||.:                    |.:...|..|.
  Rat   507 SMPAHL---------HVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATT 562

  Fly   399 FLLISISFVVCLC 411
            ...||...||..|
  Rat   563 MGFISFLGVVLFC 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	9/46 (20%)
		LRR_8	96..155	CDD:290566	22/109 (20%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	11/46 (24%)
		LRR_4	144..186	CDD:289563	16/139 (12%)
		leucine-rich repeat	145..168	CDD:275380	10/32 (31%)
		leucine-rich repeat	169..216	CDD:275380	15/107 (14%)
		LRRCT	225..274	CDD:214507	13/54 (24%)
		Ig	295..367	CDD:143165	24/81 (30%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	7/35 (20%)
		LRR	<66..371	CDD:227223	61/306 (20%)
		leucine-rich repeat	73..96	CDD:275380	8/22 (36%)
		leucine-rich repeat	97..120	CDD:275380	1/22 (5%)
		LRR_8	120..179	CDD:404697	14/58 (24%)
		leucine-rich repeat	121..144	CDD:275380	5/22 (23%)
		leucine-rich repeat	145..192	CDD:275380	11/46 (24%)
		leucine-rich repeat	193..216	CDD:275380	0/22 (0%)
		leucine-rich repeat	217..264	CDD:275380	13/48 (27%)
		leucine-rich repeat	265..288	CDD:275380	0/22 (0%)
		leucine-rich repeat	289..312	CDD:275380	1/22 (5%)
		leucine-rich repeat	313..336	CDD:275380	2/22 (9%)
		leucine-rich repeat	337..357	CDD:275380	8/19 (42%)
		PCC	341..>421	CDD:188093	24/81 (30%)
		IgI_Lingo-1	423..514	CDD:409561	29/111 (26%)
		Ig strand B	442..446	CDD:409561	1/3 (33%)
		Ig strand C	455..459	CDD:409561	1/15 (7%)
		Ig strand E	480..484	CDD:409561	1/3 (33%)
		Ig strand F	494..499	CDD:409561	3/4 (75%)
		Ig strand G	507..510	CDD:409561	2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000