DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and Lrrc4c

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001101223.1	Gene:	Lrrc4c / 311236	RGDID:	1311013	Length:	640	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	132/626 - (21%)
Similarity:	221/626 - (35%)	Gaps:	187/626 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PVCWILLCLVAWTVAD-DWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNH 80
            |:..:||.|....||. ..:.:|.|.|:|  :|.....||....|..:|:.:||..::|.|::|.
  Rat    25 PLLVVLLALQLLVVAGLVRAQTCPSVCSC--SNQFSKVICVRKNLREVPDGISTNTRLLNLHENQ 87

  Fly    81 IPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRL 145
            |..:....|.  .|.:|:.:.|.::.::.|...:|..|..|..::|.||:|..:....|:...:|
  Rat    88 IQIIKVNSFK--HLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKL 150

  Fly   146 RILYLNGNPLKRLAAYQFPILPHLRTLDMHDC-LISYIDP-----------MSLANLNLLEF--- 195
            :.|:|..||::.:.:|.|..:|.||.||:.:. .:|||..           ::||..||.|.
  Rat   151 KELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNL 215

  Fly   196 --------------------------------------------------------LNLKNNLLE 204
                                                                    :||.:|.|.
  Rat   216 TPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLT 280

  Fly   205 SLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSLV---CKGPPAQKDRTWDSV 266
            .|...:|..:.:|:.:.|..|||.|||.: .:..|::.....|.:..   |..||..|.|....:
  Rat   281 LLPHDLFTPLHHLERIHLHHNPWNCNCDI-LWLSWWIRDMAPSNTACCARCNTPPNLKGRYIGEL 344

  Fly   267 DDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESE---- 327
            |...|.|...|.:....:: |:..|......|.. ...|..|:|     |..|..|:....
  Rat   345 DQNYFTCYAPVIVEPPADL-NVTEGMAAELKCRA-STSLTSVSW-----ITPNGTVMTHGAYKVR 402

  Fly   328 -SIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISI-----------YLSEIVQHVLE- 379
             ::.||   ..|...|||..|.|.|.|..|||:|:.|.:.::           |.|.:....:|
  Rat   403 IAVLSD---GTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEP 464

  Fly   380 -------------KTPETFW----------------------------------------YFGLI 391
                         .||...|                                        ...:|
  Rat   465 SQDEARTTDNNVGPTPVIDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTKII 529

  Fly   392 MGIFGTVFLLISISFVVC--LCKRTTRQHRHANKAGVKSSVSFNDQ-------EKKLLDSSV--- 444
            :|.|..:.|:.::..|:.  :.|:..||:.||....|: .::.:|:       |..|...::
  Rat   530 IGCFVAITLMAAVMLVIFYKMRKQHHRQNHHAPTRTVE-IINVDDEITGDTPMESHLPMPAIEHE 593

  Fly   445 --------------TTTTNDRGDSYGIDNQPTSIGMNKGDS 471
                          |||.|.....:...::|..|.||..|:
  Rat   594 HLNHYNSYKSPFNHTTTVNTINSIHSSVHEPLLIRMNSKDN 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:290566	15/58 (26%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	15/53 (28%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		leucine-rich repeat	169..216	CDD:275380	18/117 (15%)
		LRRCT	225..274	CDD:214507	15/51 (29%)
		Ig	295..367	CDD:143165	22/76 (29%)
Lrrc4c	NP_001101223.1	LRRNT	47..80	CDD:214470	11/34 (32%)
		PPP1R42	65..235	CDD:411060	41/171 (24%)
		leucine-rich repeat	78..101	CDD:275380	6/24 (25%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		leucine-rich repeat	126..149	CDD:275380	6/22 (27%)
		leucine-rich repeat	150..173	CDD:275380	7/22 (32%)
		leucine-rich repeat	174..198	CDD:275380	7/23 (30%)
		leucine-rich repeat	199..220	CDD:275380	5/20 (25%)
		LRR_8	220..279	CDD:404697	3/58 (5%)
		leucine-rich repeat	221..244	CDD:275380	0/22 (0%)
		leucine-rich repeat	245..268	CDD:275380	0/22 (0%)
		LRR_8	267..>301	CDD:404697	8/33 (24%)
		leucine-rich repeat	269..290	CDD:275380	6/20 (30%)
		LRRCT	301..>339	CDD:214507	12/38 (32%)
		IG	360..443	CDD:214652	24/92 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910