DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek6 and Rtn4rl2

DIOPT Version :9

Sequence 1:NP_001263151.1 Gene:kek6 / 43729 FlyBaseID:FBgn0039862 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_852045.1 Gene:Rtn4rl2 / 311169 RGDID:727797 Length:420 Species:Rattus norvegicus


Alignment Length:319 Identity:85/319 - (26%)
Similarity:130/319 - (40%) Gaps:62/319 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 RRRSRTPRTLPVCWILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTEL 71
            ||..:.|.:  .|.:|..|....|..    ||...|||  .:...:..|.:...:::|.:|....
  Rat     6 RRLLQGPAS--ACLLLTLLALPPVTP----SCPMLCTC--YSSPPTVSCQANNFSSVPLSLPPST 62

  Fly    72 QVLVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNK-LEMLD 135
            |.|.|.:|.|..|....|..    ||..::|..:.:..|:..:||:|:.|.|:||.||: |..|:
  Rat    63 QRLFLQNNLIRSLRPGTFGP----NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLE 123

  Fly   136 KDTFMGNDRLRI------------------------------------------------LYLNG 152
            .|||.|.:||:.                                                |:|:|
  Rat   124 PDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHG 188

  Fly   153 NPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANL 217
            |.|:.|..:.|..|..|..|.:|...:..:...:...|:.|..|.|.||.|.||.......:..|
  Rat   189 NRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFHGLSRLTILYLFNNSLASLPGEALADLPAL 253

  Fly   218 KTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSLVCKGPPAQKDRTWDSVDDELF-GCPP 275
            :.|.|..|||.|:|:.|....|:..:|:||..:.|..||.::.|...::.|..| .|||
  Rat   254 EFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRTLRDTDFQACPP 312

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek6NP_001263151.1 leucine-rich repeat 71..96 CDD:275380 7/24 (29%)
LRR_8 96..155 CDD:290566 25/107 (23%)
leucine-rich repeat 97..120 CDD:275380 6/22 (27%)
leucine-rich repeat 121..144 CDD:275380 12/23 (52%)
LRR_4 144..186 CDD:289563 13/89 (15%)
leucine-rich repeat 145..168 CDD:275380 9/70 (13%)
leucine-rich repeat 169..216 CDD:275380 12/46 (26%)
LRRCT 225..274 CDD:214507 16/49 (33%)
Ig 295..367 CDD:143165
Rtn4rl2NP_852045.1 LRR_8 60..117 CDD:290566 19/60 (32%)
LRR 1 61..82 7/20 (35%)
leucine-rich repeat 62..83 CDD:275380 7/24 (29%)
LRR 2 83..104 5/20 (25%)
leucine-rich repeat 84..107 CDD:275380 6/22 (27%)
LRR_RI 103..>261 CDD:238064 39/157 (25%)
LRR 3 107..129 11/21 (52%)
LRR_8 108..167 CDD:290566 14/58 (24%)
leucine-rich repeat 108..132 CDD:275380 12/23 (52%)
LRR 4 132..153 2/20 (10%)
leucine-rich repeat 133..156 CDD:275380 1/22 (5%)
LRR_8 156..215 CDD:290566 11/58 (19%)
LRR 5 156..177 0/20 (0%)
leucine-rich repeat 157..180 CDD:275380 0/22 (0%)
LRR 6 180..201 7/20 (35%)
leucine-rich repeat 181..204 CDD:275380 8/22 (36%)
LRR_8 204..262 CDD:290566 15/57 (26%)
LRR 7 204..225 3/20 (15%)
leucine-rich repeat 205..228 CDD:275380 4/22 (18%)
LRR 8 228..249 8/20 (40%)
leucine-rich repeat 229..252 CDD:275380 8/22 (36%)
TPKR_C2 261..311 CDD:301599 16/49 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 286..390 9/27 (33%)
Important for interaction with MAG. /evidence=ECO:0000269|PubMed:19420245 315..327
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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