DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and Slitrk2

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001101057.1	Gene:	Slitrk2 / 309349	RGDID:	1561361	Length:	846	Species:	Rattus norvegicus

Alignment Length:	221	Identity:	63/221 - (28%)
Similarity:	106/221 - (47%)	Gaps:	6/221 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQV--LVLNDNHIPYLNREEFSTLGLLNLQRI 100
            |...|.|:......:..|.:...||:......:.::  |.||.|.:..|...||  :...|...:
  Rat    29 CKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEF--VNYSNAVTL 91

  Fly   101 YLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPI 165
            :|..:.:|.|...:|..||.|..:.|::||||:|.:|||:|.:.|..|..:.|.:..:.|..|..
  Rat    92 HLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYISTIEAGAFSK 156

  Fly   166 LPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLS-EYVFQHMANLKTLSLEENPWQC 229
            |..|:.|.::|.|:..: |.::....||..|:|:.|.|:.:. ..|.:|:..:..:.||||||.|
  Rat   157 LNKLKVLILNDNLLLSL-PSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNC 220

  Fly   230 NCKLRKFRGWYVNSRLSSVSLVCKGP 255
            .|.|...:.|.....:....:||:.|
  Rat   221 TCDLLPLKAWLDTITVFVGEIVCETP 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/26 (27%)
		LRR_8	96..155	CDD:290566	21/58 (36%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	11/22 (50%)
		LRR_4	144..186	CDD:289563	11/41 (27%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..216	CDD:275380	13/47 (28%)
		LRRCT	225..274	CDD:214507	10/31 (32%)
		Ig	295..367	CDD:143165
Slitrk2	NP_001101057.1	leucine-rich repeat	67..87	CDD:275378	7/21 (33%)
		LRR_8	86..146	CDD:404697	21/59 (36%)
		leucine-rich repeat	90..111	CDD:275380	5/20 (25%)
		leucine-rich repeat	112..135	CDD:275380	11/22 (50%)
		LRR_8	135..193	CDD:404697	16/58 (28%)
		leucine-rich repeat	136..159	CDD:275380	6/22 (27%)
		leucine-rich repeat	160..182	CDD:275380	5/22 (23%)
		leucine-rich repeat	183..207	CDD:275380	7/23 (30%)
		leucine-rich repeat	208..370	CDD:275380	13/39 (33%)
		TPKR_C2	216..>252	CDD:417692	10/31 (32%)
		PPP1R42	358..531	CDD:411060
		leucine-rich repeat	371..401	CDD:275380
		LRR_8	400..460	CDD:404697
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..469	CDD:275380
		leucine-rich repeat	474..492	CDD:275380
		leucine-rich repeat	497..510	CDD:275378
		leucine-rich repeat	522..534	CDD:275378
		LRRCT	530..580	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000