DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek6 and Amigo1

DIOPT Version :9

Sequence 1:NP_001263151.1 Gene:kek6 / 43729 FlyBaseID:FBgn0039862 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_996764.1 Gene:Amigo1 / 295365 RGDID:1303079 Length:493 Species:Rattus norvegicus


Alignment Length:505 Identity:129/505 - (25%)
Similarity:199/505 - (39%) Gaps:96/505 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 RTLPVCWILLC---LVAWTVADDWS--LSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQV 73
            |.|...|:||.   |:.:.||....  :||.:||.|    ......||..||..:|.:|.....:
  Rat     5 RDLRGLWLLLLSLFLLLFEVARAGRPVVSCPANCLC----ASNILSCSKQQLPNVPQSLPGYTAL 65

  Fly    74 LVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDT 138
            |.|:.|::..| :.|::...|.||..:.|..:.:.:|..|:|..:..|..:|||.|.|..||:..
  Rat    66 LDLSHNNLSRL-KAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFL 129

  Fly   139 FMGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSL---AN-LNLLEFLNLK 199
            |.|...|.:|.|..|.:..:....|..:..|:.|.:...:||.. |:.|   || |..|..|:|.
  Rat   130 FSGLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNMISRF-PLELIKDANRLPKLTLLDLS 193

  Fly   200 NNLLESLSEYVFQHM-ANLKT-LSLEENPWQCNCKLRKFRGWYVNSRLSSVSLVCKGPPAQKDRT 262
            :|.|:.|.....|.: |.:|. |.|..||.:|:|||.:....:...:||||.             
  Rat   194 SNKLKKLPLTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSSVM------------- 245

  Fly   263 WDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESE 327
              ...::|: |....::.|   |.::|.     |:|..|    .|.|||.:  :.|...:..:::
  Rat   246 --DFQEDLY-CVHSKKLHN---VFSLDF-----FNCSEY----KESAWEAH--LGDTLTITCDTK 293

  Fly   328 SIASDKLW---SNLTVFN-------------------VTSLDAGTYACTGSNSIGSMTQNISIYL 370
            .....|:|   ||..|.|                   |...|.|.|.|.......:.|.::.:.:
  Rat   294 QQGMTKVWVTPSNEQVLNQGANGTVTVSEDGNLHFKEVQVEDGGVYTCYAMGETFNETLSVELKV 358

  Fly   371 SEIVQHVLEKTPETFWYFGLIMGIFGTVFLLISISFVVCLCKRTTRQHRHANKAGVKSSVSFNDQ 435
            .....|....|..|. |..|:..|...|.:||.:....|.|.          ..||:...|  .|
  Rat   359 YNFTLHGHHDTLNTA-YTTLVGCILSVVLVLIYLYLTPCRCW----------CRGVEKPSS--HQ 410

  Fly   436 EKKLLDSSVTTTTN-------DRGDSYGIDNQPTSIGMNKGDSAGMGFNQ 478
            ...|..|.::||.|       |:.|  |.|.:...:     :.||.|..|
  Rat   411 GDSLSSSMLSTTPNHDPMAGGDKDD--GFDRRVAFL-----EPAGPGQGQ 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek6NP_001263151.1 leucine-rich repeat 71..96 CDD:275380 6/24 (25%)
LRR_8 96..155 CDD:290566 20/58 (34%)
leucine-rich repeat 97..120 CDD:275380 5/22 (23%)
leucine-rich repeat 121..144 CDD:275380 10/22 (45%)
LRR_4 144..186 CDD:289563 10/41 (24%)
leucine-rich repeat 145..168 CDD:275380 5/22 (23%)
leucine-rich repeat 169..216 CDD:275380 16/51 (31%)
LRRCT 225..274 CDD:214507 11/48 (23%)
Ig 295..367 CDD:143165 20/93 (22%)
Amigo1NP_996764.1 leucine-rich repeat 44..64 CDD:275380 6/19 (32%)
LRR 53..>242 CDD:227223 55/190 (29%)
LRR 1 62..83 5/21 (24%)
leucine-rich repeat 65..87 CDD:275380 6/22 (27%)
LRR 2 87..108 6/20 (30%)
leucine-rich repeat 88..111 CDD:275380 5/22 (23%)
LRR 3 111..132 9/20 (45%)
leucine-rich repeat 112..135 CDD:275380 10/22 (45%)
LRR 4 135..156 5/20 (25%)
leucine-rich repeat 136..159 CDD:275380 5/22 (23%)
LRR 5 159..179 6/20 (30%)
leucine-rich repeat 160..186 CDD:275380 9/26 (35%)
LRR 6 186..206 6/19 (32%)
leucine-rich repeat 187..210 CDD:275380 7/22 (32%)
IG_like 279..358 CDD:214653 14/80 (18%)
Ig strand B 285..296 CDD:409353 0/10 (0%)
Ig strand C 298..303 CDD:409353 2/4 (50%)
Ig strand C' 307..309 CDD:409353 0/1 (0%)
Ig strand D 318..321 CDD:409353 0/2 (0%)
Ig strand E 324..331 CDD:409353 0/6 (0%)
Ig strand F 337..345 CDD:409353 3/7 (43%)
Ig strand G 348..358 CDD:409353 1/9 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 405..493 15/58 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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