DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and Lingo2

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001159471.1	Gene:	Lingo2 / 242384	MGIID:	2442298	Length:	606	Species:	Mus musculus

Alignment Length:	577	Identity:	118/577 - (20%)
Similarity:	194/577 - (33%)	Gaps:	214/577 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CW-------ILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVL 76
            ||       ::|.|:..|:      .|.:.|.|...|  ||..|...:|..||..:..|.::|.|
Mouse     8 CWQPFLGLAVVLLLMGSTI------GCPARCECSAQN--KSVSCHRRRLLAIPEGIPIETKILDL 64

  Fly    77 NDNHIPYLNREEFSTLGLL----------------------NLQRIYLKKSEVQYIHKESFRNLK 119
            :.|.:..:|.|||.:..||                      ||:.:.||.:.::.:....|..|.
Mouse    65 SKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLS 129

  Fly   120 ILVEIDLSDNK-----------------LEMLDKDTFMGNDR----------------------- 144
            .|.::|:|:||                 ||:.|.|....:.|
Mouse   130 NLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPT 194

  Fly   145 -----------LRILYLNGNPLKRLAAYQFPILPHLRTLDMH-----DCL--------------- 178
                       |.:.:||   :..:..|.|..|.||:.|::.     |.:
Mouse   195 EALSHLRSLIALHLKHLN---INNMPVYAFKRLFHLKNLEIDYWPLLDLMPANSLYGLNLTSLSI 256

  Fly   179 -----------------------ISY-----------------------------IDPMSLANLN 191
                                   :||                             |:|.|...|.
Mouse   257 TNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLR 321

  Fly   192 LLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYV----NSRLSSVSLVC 252
            .|..||:..||||:|.|.||.....|:.||:..||..|:|:|.    |.:    |.:......:|
Mouse   322 FLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLL----WLLQRQPNLQFGGQQPMC 382

  Fly   253 KGPPAQKDRTWDSVDDE----LFGC-PPRVEIFNNEEVQN--IDIGSNTTFSCLVYGDPLPEVAW 310
            .||...::|::......    .|.| .|::   ..:::|:  :|.|......|...|||.|.::|
Mouse   383 AGPDTIRERSFKDFHSTALSFYFTCKKPKI---REKKLQHLLVDEGQTVQLECNADGDPQPVISW 444

  Fly   311 ----------ELNGKIL-------------DNDN---VLFESESIASDKLWSNLTVFNVTSLDAG 349
                      :.||:..             |.|:   |...|.:..:|...::|||...|| |..
Mouse   445 VTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFTS-DRF 508

  Fly   350 TYA------CTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMGIFGTVFL 400
            .||      .|.||...|...|.:.:..::...::......|.:.|:::..|..:|:
Mouse   509 LYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFV 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	9/46 (20%)
		LRR_8	96..155	CDD:290566	19/109 (17%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	9/39 (23%)
		LRR_4	144..186	CDD:289563	15/147 (10%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..216	CDD:275380	20/118 (17%)
		LRRCT	225..274	CDD:214507	13/57 (23%)
		Ig	295..367	CDD:143165	26/103 (25%)
Lingo2	NP_001159471.1	LRRNT	27..60	CDD:214470	11/34 (32%)
		leucine-rich repeat	39..57	CDD:275380	6/17 (35%)
		LRR 1	58..79		8/20 (40%)
		leucine-rich repeat	59..82	CDD:275380	7/22 (32%)
		LRR_8	60..117	CDD:404697	13/56 (23%)
		LRR 2	82..103		2/20 (10%)
		leucine-rich repeat	83..106	CDD:275380	1/22 (5%)
		LRR_8	106..165	CDD:404697	14/58 (24%)
		LRR 3	106..127		5/20 (25%)
		leucine-rich repeat	107..130	CDD:275380	5/22 (23%)
		LRR 4	130..151		5/20 (25%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR 5	154..175		5/20 (25%)
		leucine-rich repeat	155..178	CDD:275380	5/22 (23%)
		PPP1R42	176..>373	CDD:411060	36/203 (18%)
		LRR 6	178..199		0/20 (0%)
		leucine-rich repeat	179..202	CDD:275380	0/22 (0%)
		LRR 7	202..223		5/23 (22%)
		leucine-rich repeat	203..250	CDD:275380	10/49 (20%)
		LRR 8	226..247		4/20 (20%)
		LRR 9	250..271		0/20 (0%)
		leucine-rich repeat	251..274	CDD:275380	0/22 (0%)
		LRR 10	274..295		2/20 (10%)
		leucine-rich repeat	275..298	CDD:275380	2/22 (9%)
		LRR 11	298..319		3/20 (15%)
		leucine-rich repeat	299..322	CDD:275380	4/22 (18%)
		LRR 12	322..343		11/20 (55%)
		leucine-rich repeat	323..343	CDD:275380	11/19 (58%)
		LRRCT	355..408	CDD:214507	12/56 (21%)
		Ig	411..500	CDD:416386	17/91 (19%)
		Ig strand A'	417..421	CDD:409353	1/3 (33%)
		Ig strand B	427..436	CDD:409353	1/8 (13%)
		Ig strand C	441..446	CDD:409353	1/4 (25%)
		Ig strand C'	449..451	CDD:409353	0/1 (0%)
		Ig strand D	460..463	CDD:409353	0/2 (0%)
		Ig strand E	466..473	CDD:409353	0/6 (0%)
		Ig strand F	479..487	CDD:409353	1/7 (14%)
		Ig strand G	490..500	CDD:409353	2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000