DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and Lingo3

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001013780.2	Gene:	Lingo3 / 237403	MGIID:	3609246	Length:	589	Species:	Mus musculus

Alignment Length:	523	Identity:	113/523 - (21%)
Similarity:	176/523 - (33%)	Gaps:	182/523 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CWI------LLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLN 77
            ||:      ||.|....:|    ..|.:.|.|  :...::..|...:||.||..:..|.::|.|:
Mouse     3 CWLHMLGLHLLLLPTAPLA----AGCPARCEC--SASTRTVACGRRRLTAIPEGIPAETRMLELS 61

  Fly    78 DNHIPYLNREEFSTLGLL-------------------NLQR---IYLKKSEVQYIHKESFRNLKI 120
            .|.|..||..:.::|..|                   ||.|   :.|:.::::.|....|.:|..
Mouse    62 RNRIRCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTHLDS 126

  Fly   121 LVEIDLSDNKLEML-----------------DKDTF----------------------------- 139
            |..:|||:|||.:|                 |.|..
Mouse   127 LTLLDLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRAFAGLLGLAELTLERCNLTSLSPE 191

  Fly   140 -------MGNDRLR--------------------------------------------------- 146
                   :|..|||
Mouse   192 SLGHLRGLGALRLRHLAIAALEDQNFQKLPGLSHLEIDNWPLLEEVAPGSLRGLNLTSLSITHTN 256

  Fly   147 ----------------ILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEF 195
                            .|.|:.||:..:....|..|..||.|.:...|::.|:|.:...|..:..
Mouse   257 ITAVPAAALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQIRL 321

  Fly   196 LNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSL-----VCKGP 255
            |||.:|||.:|.|..|..:..|:||.::.||..|:|:|.    |.|..| .:::.     .|..|
Mouse   322 LNLSDNLLSTLEENTFHSVNTLETLRVDGNPLACDCRLL----WIVQRR-KTLNFDGRLPACATP 381

  Fly   256 PAQKDRTW----DSVDDELFGC-PPRVEIFNNEEVQNIDI--GSNTTFSCLVYGDPLPEVAWELN 313
            ...:....    |||..|.|.| .|::   ....:|::..  |.:..|.|...|:|.|.|||...
Mouse   382 AEVRGDALHNLPDSVLFEYFVCRKPKI---RERRLQHVTATEGDDVRFLCRAEGEPAPTVAWVTP 443

  Fly   314 GKILDNDNVLFESESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVL 378
                .:.:|...|...|.......||:.:....|:|||.|..||:.|    |.:.:.:..||...
Mouse   444 ----QHHSVTAASRGRARVLPGGTLTIADTRPQDSGTYTCVASNAGG----NDTYFATLTVQPAA 500

  Fly   379 EKT 381
            .:|
Mouse   501 NRT 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/43 (19%)
		LRR_8	96..155	CDD:290566	24/181 (13%)
		leucine-rich repeat	97..120	CDD:275380	6/25 (24%)
		leucine-rich repeat	121..144	CDD:275380	11/75 (15%)
		LRR_4	144..186	CDD:289563	15/108 (14%)
		leucine-rich repeat	145..168	CDD:275380	8/89 (9%)
		leucine-rich repeat	169..216	CDD:275380	16/46 (35%)
		LRRCT	225..274	CDD:214507	16/58 (28%)
		Ig	295..367	CDD:143165	22/71 (31%)
Lingo3	NP_001013780.2	LRRNT	23..55	CDD:214470	8/33 (24%)
		leucine-rich repeat	34..53	CDD:275380	5/18 (28%)
		LRR 1	54..75		7/20 (35%)
		LRR	<55..353	CDD:227223	55/297 (19%)
		leucine-rich repeat	55..78	CDD:275380	7/22 (32%)
		LRR 2	78..99		1/20 (5%)
		leucine-rich repeat	79..102	CDD:275380	3/22 (14%)
		LRR 3	102..123		4/20 (20%)
		leucine-rich repeat	103..150	CDD:275380	12/46 (26%)
		LRR 4	126..147		8/20 (40%)
		LRR 5	150..171		2/20 (10%)
		leucine-rich repeat	151..174	CDD:275380	2/22 (9%)
		LRR 6	174..195		0/20 (0%)
		leucine-rich repeat	175..198	CDD:275380	0/22 (0%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		LRR 7	206..227		0/20 (0%)
		leucine-rich repeat	223..246	CDD:275380	0/22 (0%)
		LRR_8	246..302	CDD:338972	9/55 (16%)
		LRR 8	246..267		0/20 (0%)
		leucine-rich repeat	247..270	CDD:275380	0/22 (0%)
		LRR 9	270..291		5/20 (25%)
		leucine-rich repeat	271..292	CDD:275380	5/20 (25%)
		LRR 10	294..315		6/20 (30%)
		leucine-rich repeat	295..318	CDD:275380	7/22 (32%)
		LRR 11	318..339		9/20 (45%)
		leucine-rich repeat	321..342	CDD:275380	9/20 (45%)
		PCC	331..>405	CDD:188093	22/78 (28%)
		I-set	406..496	CDD:369462	25/100 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910