DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek6 and Lingo1

DIOPT Version :9

Sequence 1:NP_001263151.1 Gene:kek6 / 43729 FlyBaseID:FBgn0039862 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_006511149.1 Gene:Lingo1 / 235402 MGIID:1915522 Length:647 Species:Mus musculus


Alignment Length:598 Identity:131/598 - (21%)
Similarity:200/598 - (33%) Gaps:224/598 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RSMDRRRSRTPRTLPVCW-ILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNT 66
            |||       |..|..|| .:|.||..:|....:..|...|.|...:  ::.:|...:...:|..
Mouse    40 RSM-------PSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQD--RAVLCHRKRFVAVPEG 95

  Fly    67 LSTELQVLVLNDNHIPYLNREEFSTL----------------------GLLNLQRIYLKKSEVQY 109
            :.||.::|.|..|.|..||::||::.                      .|.||:.:.|:.:.::.
Mouse    96 IPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKL 160

  Fly   110 IHKESFRNLKILVEIDLSDNK-----------------LEMLDKD-------TFMGNDR------ 144
            |....|..|..|.::|:|:||                 ||:.|.|       .|.|.:.      
Mouse   161 IPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTL 225

  Fly   145 ---------------------LRILYLNGNPL-----KRLAAYQFPIL-----PHLRTLD----- 173
                                 ||:.:||.|.:     |||  |:..:|     |:|.|:.     
Mouse   226 EKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRL--YRLKVLEISHWPYLDTMTPNCLY 288

  Fly   174 ---------------------------------------------MHDCL-----------ISYI 182
                                                         :|:.|           ::.:
Mouse   289 GLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVV 353

  Fly   183 DPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKF--RGWYVNSRL 245
            :|.:...||.|..||:..|.|.:|.|..|..:.||:||.|:.||..|:|:|...  |.|.:|  .
Mouse   354 EPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLN--F 416

  Fly   246 SSVSLVCKGPPAQKDRTWDSVDDEL----FGCPPRVEIFNNEEVQ-NIDIGSNTTFSCLVYGDPL 305
            :.....|..|...:.:.:....|.|    |.| .|..|.:.:..| .:|.|....|.|...|||.
Mouse   417 NRQQPTCATPEFVQGKEFKDFPDVLLPNYFTC-RRAHIRDRKAQQVFVDEGHTVQFVCRADGDPP 480

  Fly   306 PEVAWELNGKILDNDNVLFESESIASDKLWSNLTVFNVTSL--------DAGTYACTGSNSIG-- 360
            |.:.|            |...:.:.|.|....||||...:|        |.|||.|..:|:.|  
Mouse   481 PAILW------------LSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGND 533

  Fly   361 SMTQNISIYLSEIVQHVLEKTPE-------TFWY--------------------FGLIMGIFGTV 398
            ||..::         ||...:|:       ||.:                    |.:...|..|.
Mouse   534 SMPAHL---------HVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATT 589

  Fly   399 FLLISISFVVCLC 411
            ...||...||..|
Mouse   590 MGFISFLGVVLFC 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek6NP_001263151.1 leucine-rich repeat 71..96 CDD:275380 9/46 (20%)
LRR_8 96..155 CDD:290566 22/109 (20%)
leucine-rich repeat 97..120 CDD:275380 5/22 (23%)
leucine-rich repeat 121..144 CDD:275380 11/46 (24%)
LRR_4 144..186 CDD:289563 16/139 (12%)
leucine-rich repeat 145..168 CDD:275380 10/32 (31%)
leucine-rich repeat 169..216 CDD:275380 15/107 (14%)
LRRCT 225..274 CDD:214507 13/54 (24%)
Ig 295..367 CDD:143165 24/81 (30%)
Lingo1XP_006511149.1 LRRNT 68..102 CDD:214470 7/35 (20%)
LRR <93..398 CDD:227223 61/306 (20%)
leucine-rich repeat 100..123 CDD:275380 8/22 (36%)
leucine-rich repeat 124..147 CDD:275380 1/22 (5%)
LRR_8 147..206 CDD:338972 14/58 (24%)
leucine-rich repeat 148..171 CDD:275380 5/22 (23%)
leucine-rich repeat 172..219 CDD:275380 11/46 (24%)
leucine-rich repeat 220..243 CDD:275380 0/22 (0%)
leucine-rich repeat 244..291 CDD:275380 13/48 (27%)
leucine-rich repeat 292..315 CDD:275380 0/22 (0%)
leucine-rich repeat 316..339 CDD:275380 1/22 (5%)
leucine-rich repeat 340..363 CDD:275380 2/22 (9%)
leucine-rich repeat 364..384 CDD:275380 8/19 (42%)
PCC 368..>448 CDD:188093 24/81 (30%)
Ig 466..541 CDD:386229 25/95 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8825
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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