DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and pxn-1

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_505188.3	Gene:	pxn-1 / 191484	WormBaseID:	WBGene00004256	Length:	1285	Species:	Caenorhabditis elegans

Alignment Length:	677	Identity:	139/677 - (20%)
Similarity:	220/677 - (32%)	Gaps:	284/677 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WILLCLVAWTVADDW----SLSCASNCTCKWTNGKKSAI--CSSLQLTTIPNTLSTELQVLVLND 78
            ::||.::|   ...|    .|.|...|||    .||..:  |||..||.||..:|..::.||:.:
Worm     4 YLLLLVIA---TSSWQFVAGLECPVECTC----DKKGLVVDCSSSGLTRIPKNISRNVRSLVIRN 61

  Fly    79 NHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGND 143
            |.|..|.|.:.                       |.|..|:.||   |:.||::::::
Worm    62 NRIHKLKRSDL-----------------------EGFNQLETLV---LTHNKIKIIEE------- 93

  Fly   144 RLRILYLNGNPLKRLAAYQFPILPHLRTLDM-HDCLISYIDPM-----SLANLNL----LEF--- 195
                     |.|..        ||.|:.|.: |:.|: ||.|:     .||:|||    ::|
Worm    94 ---------NVLDH--------LPELKRLSLAHNELV-YIPPLCSDSRPLASLNLKRNHIQFIDE 140

  Fly   196 -----------LNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSV- 248
                       |:..:|.::||...:|.::..|....|..|||.|:|:..|     |.:.|..|
Worm   141 QVLRYFPDLTQLDFSHNRIQSLRTKLFDNLPALSHAHLHSNPWHCDCRASK-----VKALLQKVK 200

  Fly   249 ---SLVCKGPPAQKDRTWDSVDDELFGCP-PRVEIFNNEEV-----------------QNIDI-- 290
               .:.|..|...:.:..|.|||....|. |..|.:..||:                 :|:::
Worm   201 WEKKVYCTNPVELRHQALDEVDDSALTCARPAEESWTGEEIKLTCAKNSSSKLVVWMYENVEVDS 265

  Fly   291 ---------------------------------------------------------------GS 292
                                                                           ||
Worm   266 SSLDGYEIHDTVITVPRKTNVNFMTCTYDFDHIPHHRRLRQSQHQGNGSPQFTYKPRDNSFREGS 330

  Fly   293 NTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESESIASDK----LWSN-LTVFNVTSLDAGTYA 352
            ....:|.|.|:|.|.:.|..|||           ..|:|.|    |.:| |.::.....|:|.|.
Worm   331 EVKVNCEVMGNPKPTINWYHNGK-----------RFISSRKRQLGLSNNVLRIYPFLEEDSGRYT 384

  Fly   353 CTGSNSIGSMTQNISI-YLSEIVQHVLE----------------------KTPETFWYF-----G 389
            |...||:|.:....|: .:|.:..::.|                      ..|:..|.|     |
Worm   385 CEAVNSVGKVRHAFSLDLISSVPPNIYEGPQSVSQNLGGSVVFVCKANGNPVPDYTWSFDGSTIG 449

  Fly   390 LIMGIF-----GTVFLLISI-----SFVVCL-----------CKRT-----TRQ----------- 417
            .|.|.|     ||...:.:|     .:..|:           .|.|     ||:
Worm   450 HIKGRFMVSDDGTELRISNIEKKDEGYYSCMAGNPVGAMSADAKLTVIGGETRKAAAPQIDEELL 514

  Fly   418 HRHANKA--GVKSSVSFNDQEKKLLDSSVTTTTNDRGDSYGIDNQPTSIGMNKGD---------- 470
            ...|.||  .|:::|   ::.:|.|.....|.|||....:.......::.::|..
Worm   515 RAIAQKARQNVENAV---EKTRKQLTQDKVTNTNDLKRLFRFSTPKQAVELSKAREIYEESVRLV 576

  Fly   471 ----SAGMGFNQIEIH----AVESHRH 489
                ..|:..|..|:|    :.||..|
Worm   577 REHVEKGLILNVDELHPKNVSYESVLH 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:290566	9/58 (16%)
		leucine-rich repeat	97..120	CDD:275380	3/22 (14%)
		leucine-rich repeat	121..144	CDD:275380	5/22 (23%)
		LRR_4	144..186	CDD:289563	11/47 (23%)
		leucine-rich repeat	145..168	CDD:275380	3/22 (14%)
		leucine-rich repeat	169..216	CDD:275380	18/70 (26%)
		LRRCT	225..274	CDD:214507	15/52 (29%)
		Ig	295..367	CDD:143165	22/76 (29%)
pxn-1	NP_505188.3	LRRNT	23..51	CDD:279764	13/31 (42%)
		leucine-rich repeat	35..53	CDD:275380	8/17 (47%)
		LRR_8	52..112	CDD:290566	21/109 (19%)
		LRR_4	53..93	CDD:289563	14/65 (22%)
		leucine-rich repeat	54..77	CDD:275380	8/45 (18%)
		LRR_4	77..120	CDD:289563	17/70 (24%)
		leucine-rich repeat	78..101	CDD:275380	9/49 (18%)
		leucine-rich repeat	102..117	CDD:275380	6/15 (40%)
		LRR_8	123..182	CDD:290566	13/58 (22%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		I-set	315..400	CDD:254352	24/95 (25%)
		IGc2	328..392	CDD:197706	23/74 (31%)
		IG_like	414..496	CDD:214653	12/81 (15%)
		Ig	420..496	CDD:299845	12/75 (16%)
		An_peroxidase	634..1181	CDD:281139
		peroxidasin_like	757..1203	CDD:188658
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910