DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and LRFN5

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001333102.1	Gene:	LRFN5 / 145581	HGNCID:	20360	Length:	719	Species:	Homo sapiens

Alignment Length:	382	Identity:	89/382 - (23%)
Similarity:	158/382 - (41%)	Gaps:	55/382 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFSTLGLLNLQRIYL 102
            |...|.|:..:...:.:|:...|..:|..:......|.|.||.:..:.|::|:  .:.:|..:.|
Human    20 CPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFA--NMTSLVDLTL 82

  Fly   103 KKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPILP 167
            .::.:.:|...:|.:|:.|..:.|:.|:|..:..|.|.|...|..|.||.|.|..:::..|..:.
Human    83 SRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVF 147

  Fly   168 HLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANLK-------------- 218
            .|..||:....:..|...::..:..|..|:|.:|:::::.:..|.|:..:.
Human   148 ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPP 212

  Fly   219 ---------------------TLSLEENPWQCNCKLRKFRGWYVNSRLSSVS--LVCKGPPAQKD 260
                                 .||...||..|||:|...|      |||...  ..|..||....
Human   213 DPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLR------RLSREDDLETCASPPLLTG 271

  Fly   261 RTWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAW-ELNGKILDNDNVLF 324
            |.:.|:.:|.|.|.|.:...:..|::.:: |...|..|...|||.|.:.| ...||::.|
Human   272 RYFWSIPEEEFLCEPPLITRHTHEMRVLE-GQRATLRCKARGDPEPAIHWISPEGKLISN----- 330

  Fly   325 ESESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKT 381
            .:.|:..|.  ..|.:...|..|.|.:.|..||..|..||.:.:::.:: .|:|..|
Human   331 ATRSLVYDN--GTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKL-PHLLNST 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:290566	17/58 (29%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_4	144..186	CDD:289563	11/41 (27%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		leucine-rich repeat	169..216	CDD:275380	10/46 (22%)
		LRRCT	225..274	CDD:214507	17/50 (34%)
		Ig	295..367	CDD:143165	22/72 (31%)
LRFN5	NP_001333102.1	LRR 1	52..73		6/22 (27%)
		LRR 2	76..97		4/20 (20%)
		LRR 3	100..121		6/20 (30%)
		LRR 4	124..145		7/20 (35%)
		LRR 5	148..169		4/20 (20%)
		LRR 6	172..193		5/20 (25%)
		LRR 7	196..217		0/20 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..414		89/382 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	615..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960