DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and lrrc4bb

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_003201401.1	Gene:	lrrc4bb / 100535350	ZFINID:	ZDB-GENE-091116-44	Length:	726	Species:	Danio rerio

Alignment Length:	741	Identity:	158/741 - (21%)
Similarity:	251/741 - (33%)	Gaps:	241/741 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PVCWILLCLVAW------TVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLV 75
            |:.| |:.|:.|      .:|:. |.:|.:.|:|  :|.....||:...|..:|.::|:..:.|.
Zfish    14 PLIW-LVQLLLWPHLLGPRLAEA-SPACPALCSC--SNQASRVICTKKSLNEVPQSISSNTRYLN 74

  Fly    76 LNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFM 140
            |.:|.|..:..:.|..|.  :|:.:.|.|::::.|...:|..|..|:.::|.||:|.::....|.
Zfish    75 LQENSIQVIRSDTFKHLN--HLEILQLSKNQIRQIEVGAFNGLPNLITLELFDNRLPLVPSQAFE 137

  Fly   141 GNDRLRILYLNGNPLKRLAAYQFPILPHLRTLD-------------------------------- 173
            ...:||.|:|..||::.|.||.|..:|.||.||
Zfish   138 YLSKLRELWLRNNPIETLPAYAFHRVPSLRRLDLGELRKLSFISEAAFEGLLNLRFLNLGMCGLK 202

  Fly   174 ----------------------------------------MHDCLISYIDPMSLANLNLLEFLNL 198
                                                    ||. .||.|:..:..:|..||.|||
Zfish   203 DVPNLTPLVRLEELELSGNQLGVVRPGSFQGLVSLRKLWLMHS-RISVIERNAFDDLKNLEELNL 266

  Fly   199 KNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRL---SSVSLVCKGPPAQKD 260
            .:|.|.||...:|..:..|:.:.|..|||.|||.: .:..|::...:   |:....|..||..|.
Zfish   267 SHNSLHSLPHDLFTPLQQLERVHLNHNPWVCNCDV-LWLSWWLKETVPDNSTCCARCHAPPGTKG 330

  Fly   261 RTWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAW-ELNGKILDND---- 320
            |....:|...|.|...|.:....:: |:..|......|.. |..:..|.| ..||.::.:.
Zfish   331 RYIGDLDQRDFTCYAPVIVEPPTDL-NVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGAYKV 393

  Fly   321 --NVLFESESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQ----NISI--------YLS 371
              :||.:          ..|...|||..|.|.|.|..:||.|:.|.    |:|.        |.:
Zfish   394 RISVLHD----------GTLNFTNVTMQDTGPYTCMVTNSAGNTTATAVLNVSAPDPGNGYSYFT 448

  Fly   372 EIVQHVLE------KTP------ETFWYF------------------------------------ 388
            .:....:|      .:|      |||..|
Zfish   449 TVTVETVETGQEGHDSPARQFVNETFISFPGPTAASTSAGPTGSMLSSLSPRATRAPDRPFTVSI 513

  Fly   389 -------GL---------IMGIFGTVFLLISISFVVCLCKRTTRQ-HRHANKAGVKSSVSFNDQE 436
                   ||         |:|.|..:..:.::..||....|...| |:|...|.....::..|:
Zfish   514 TDVANLSGLEDVMKTTKIIIGCFVAITFMAAVMLVVFYKLRKQHQLHKHHGPARAIEIINVEDE- 577

  Fly   437 KKLLDSSVTTTTNDRGDSYGIDNQPTSIGMNKGDSAGMGFNQI-EIH--------AVESHRHGSM 492
                       ....|.:.||....|   ::.|...|.|..|. .||        :|....|.:.
Zfish   578 -----------IGSAGGASGITGGST---VHTGAGTGGGSGQSPRIHDPEIMTLPSVGQADHLNH 628

  Fly   493 LVQQQPQQQQVAGGGGMRQQLMQVKDSTCGMMS---VPTSM----------AGHAHSHPAQISEE 544
            ..:.......|.|           .:.|.||::   .|:|.          ||....:|..||..
Zfish   629 YYKAHHFNNNVLG-----------LNMTTGMLNNKPNPSSQNQASTLKMGPAGDLGPNPGSISPP 682

  Fly   545 FPLNVGVFPPPPEFCSNI-----VPN 565
            .|:.:   |....|..::     |||
Zfish   683 LPIPI---PMAMTFHGSLKGHSHVPN 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:290566	17/58 (29%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	20/113 (18%)
		leucine-rich repeat	145..168	CDD:275380	10/22 (45%)
		leucine-rich repeat	169..216	CDD:275380	20/118 (17%)
		LRRCT	225..274	CDD:214507	15/51 (29%)
		Ig	295..367	CDD:143165	21/82 (26%)
lrrc4bb	XP_003201401.1	LRRNT	38..72	CDD:214470	9/35 (26%)
		LRR_8	68..128	CDD:290566	16/61 (26%)
		leucine-rich repeat	70..93	CDD:275380	6/24 (25%)
		LRR_RI	85..293	CDD:238064	47/210 (22%)
		leucine-rich repeat	94..117	CDD:275380	6/22 (27%)
		leucine-rich repeat	118..141	CDD:275380	6/22 (27%)
		LRR_8	140..196	CDD:290566	15/55 (27%)
		leucine-rich repeat	142..165	CDD:275380	10/22 (45%)
		leucine-rich repeat	166..190	CDD:275380	4/23 (17%)
		leucine-rich repeat	191..212	CDD:275380	0/20 (0%)
		LRR_8	212..271	CDD:290566	12/59 (20%)
		leucine-rich repeat	213..236	CDD:275380	0/22 (0%)
		leucine-rich repeat	237..260	CDD:275380	6/23 (26%)
		leucine-rich repeat	261..282	CDD:275380	10/20 (50%)
		TPKR_C2	293..343	CDD:301599	15/50 (30%)
		IG_like	352..435	CDD:214653	22/94 (23%)
		Ig	360..435	CDD:299845	21/85 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910