DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and slitrk5b

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_002667367.2	Gene:	slitrk5b / 100331252	ZFINID:	ZDB-GENE-110408-55	Length:	856	Species:	Danio rerio

Alignment Length:	623	Identity:	121/623 - (19%)
Similarity:	232/623 - (37%)	Gaps:	167/623 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIP-NTLSTELQV--------------- 73
            ::|:.......|.|.:.|||            :||::.:. |....|.::
Zfish   347 MLAYQTKSPVPLDCPNTCTC------------NLQISDLGLNVNCQERKIESISDLDPKPYNPKK 399

  Fly    74 LVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDT 138
            :.|..|:|..:...:||  |...|..::|..:.:..:|.::|..|..|..:.|:.|.:|.|.:|.
Zfish   400 MYLTGNYISSVCSSDFS--GATGLDLLHLGNNRIAVVHDKTFGQLIHLRRLYLNGNLIERLTEDM 462

  Fly   139 FMGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLL 203
            |.|...|:.|||..|.::.:|...|..||:|:.|.:::.|:..:.......|||.. |||::|..
Zfish   463 FYGLQSLQFLYLEYNVIREIAVGTFQQLPNLQLLFLNNNLLKTLHLGIFDGLNLAR-LNLRSNHF 526

  Fly   204 ESLSEY-VFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSV--SLVCKGPPAQKDRTWDS 265
            .:|... |...:|:|..:.|.||||.|:|.:...:.|.......:|  :::|:.||.
Zfish   527 RTLPVIGVLDELASLIQIDLFENPWDCSCSILDMKNWLEQLSAGTVVNTVICESPPR-------- 583

  Fly   266 VDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESESI- 329
                          .:.|:::.|    .::..|       ||             :.:.:|.::
Zfish   584 --------------LSGEDMRYI----RSSHIC-------PE-------------SSIAQSSAVP 610

  Fly   330 ASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMGI 394
            .|::.:...|:...|:||..             ||..::.||.::..:|         ...|:.:
Zfish   611 PSEESFPGSTITLETALDFD-------------TQYPAVPLSVLILALL---------LLFILSV 653

  Fly   395 FGTVFLLISISFVVCLCKRTTRQHRHAN---------KAGVKSSVSFNDQEKKLLDSSVTTTTND 450
            |      |:......:.||..:..|.|:         :|.:||..|.....:.:..|:.....|.
Zfish   654 F------IAAGLFAVIMKRRKKSERSASVTASAIYTERANMKSRTSAGHVYEYIPPSAENAAKNG 712

  Fly   451 RGDSYGIDNQPTSIGMNKGDSAGMGFNQIEIHAVES----------HRHGSML--------VQQQ 497
            |.:...|:|......:|: ..|.....:|..:|:.|          :|:..:|        :..:
Zfish   713 RYNPSAIENYRDFEELNR-VLASNSDEEIRSNAISSEFSAGTPDPLNRNSPLLDDNYFYRDILAR 776

  Fly   498 PQQQQVAGGGGMRQQLMQVKDSTCGMMSVPTSMAGHAHSHPAQISEEFPLNVGVFPPPPEFCSNI 562
            .||....|.       :..|..|.....|     ||.:.:|.::.:..           .:||
Zfish   777 DQQASYRGH-------LPCKHGTHADFDV-----GHQYLNPERVQQTM-----------VYCS-- 816

  Fly   563 VPNPAFGGNIFIRVSVTQDMLDGADLNMYPDLLNIPKR 600
              :|.   .::|..:.::.....|.|:..||.|.:.::
Zfish   817 --SPT---TVYIEPNRSECWELRAKLHFEPDYLEVHEK 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/39 (15%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_4	144..186	CDD:289563	12/41 (29%)
		leucine-rich repeat	145..168	CDD:275380	8/22 (36%)
		leucine-rich repeat	169..216	CDD:275380	12/47 (26%)
		LRRCT	225..274	CDD:214507	10/50 (20%)
		Ig	295..367	CDD:143165	11/72 (15%)
slitrk5b	XP_002667367.2	LRR_8	79..136	CDD:290566
		leucine-rich repeat	80..101	CDD:275380
		LRR_RI	<101..283	CDD:238064
		leucine-rich repeat	102..125	CDD:275380
		LRR_8	125..184	CDD:290566
		leucine-rich repeat	126..149	CDD:275380
		leucine-rich repeat	150..173	CDD:275380
		LRR_8	172..230	CDD:290566
		leucine-rich repeat	174..189	CDD:275380
		leucine-rich repeat	197..221	CDD:275380
		leucine-rich repeat	222..367	CDD:275380	6/31 (19%)
		LRRCT	230..>268	CDD:214507
		leucine-rich repeat	368..420	CDD:275380	10/53 (19%)
		leucine-rich repeat	376..397	CDD:275380	2/20 (10%)
		LRR_8	419..479	CDD:290566	18/59 (31%)
		leucine-rich repeat	421..444	CDD:275380	5/22 (23%)
		LRR_4	444..482	CDD:289563	13/37 (35%)
		leucine-rich repeat	445..468	CDD:275380	8/22 (36%)
		leucine-rich repeat	469..488	CDD:275380	6/18 (33%)
		leucine-rich repeat	493..515	CDD:275380	3/21 (14%)
		leucine-rich repeat	516..540	CDD:275380	7/24 (29%)
		LRRCT	549..599	CDD:214507	13/82 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000