DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and lrfn5a

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_001921674.1	Gene:	lrfn5a / 100144400	ZFINID:	ZDB-GENE-080327-17	Length:	786	Species:	Danio rerio

Alignment Length:	884	Identity:	174/884 - (19%)
Similarity:	292/884 - (33%)	Gaps:	269/884 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLN 85
            :|:||:...:|....: |...|.|:..:...:.:|:...|..:|..:......|.|.||.:..:.
Zfish     4 LLVCLLVIGMAVKAQI-CPKRCVCQVLSPNLATLCAKKGLLFVPPNIDRHTVELRLADNFVTSVK 67

  Fly    86 REEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYL 150
            |::.:  .:..|..:.|.::.:.||...:|.:|:.|..:.|..|:|..:..|||.|..:|..|.|
Zfish    68 RKDLA--NMTKLVDLTLSRNTISYITPHAFADLENLRALHLDHNRLTRIANDTFSGMSKLHHLIL 130

  Fly   151 NGNPL---------KRLAAYQFPI---------------LPHLRTLDMHDCLISYIDPMSLANLN 191
            |.|.|         ..||..:..:               :..|.||.:...:|.||...:.:.|.
Zfish   131 NNNQLTLIHMGAFNDLLALEELDLSYNNLETIPWEAIQRMTSLHTLSLDHNMIEYIPEGTFSLLQ 195

  Fly   192 LLEFLNLKNNLLESL-SEYVFQHMANLKT----------LSLEENPWQCNCKLRKFRGWYVNSRL 245
            .|..|::.:|.|:.| .:.:||....|.|          ||...||..|||:|...|.......|
Zfish   196 KLNRLDVTSNKLQKLPPDPLFQRAQVLATSGIMNPSSFALSFGGNPLHCNCELLWLRRLNREDDL 260

  Fly   246 SSVSLVCKGPPAQKDRTWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAW 310
            .:    |..|.....|.:.|:.:|.|.|.|.:...::.|::.:: |......|...|||.|.:.|
Zfish   261 ET----CATPLHLSGRYFWSIPEEEFLCEPPLITRHSHEMRVLE-GQRVALKCKARGDPEPAIHW 320

  Fly   311 -ELNGKILDNDNVLFESESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIV 374
             ...||::.|     .|.::..:.  ..|.:...|..|.|::.|..||..|...|.|.:
Zfish   321 ISPEGKLVSN-----TSRTLVYNN--GTLDILISTVKDTGSFTCISSNPAGEAHQTIEL------ 372

  Fly   375 QHVLEKTPETFWYFGLIMGIFGTVFLLISISFVVCLCKRTTRQHRHANKAGVKSSVSFNDQEKKL 439
              |:.|.|..                                           |:.:.|.||...
Zfish   373 --VIIKLPHI-------------------------------------------SNSTNNIQEPDP 392

  Fly   440 LDSSVTTTT-------NDRGDSYGIDNQPTSIGMNKGDSAGMGFN-----------QIEIHAVES 486
            ..|.::|:|       |..||:....::...:......:|.:.||           ||:.:....
Zfish   393 GSSDISTSTRAGANGGNHTGDTKTSSDKRVVMAEATSSTALIKFNFQRNIPGIRMFQIQYNGTYD 457

  Fly   487 HRHGSMLVQQQPQQQQ------VAGGGGMRQQLMQVKDSTCGMMSV-PTSMAGHAHSHPAQISEE 544
               .|::.:..|...:      :|.|......::.:.|.  ||.|: .|.:.|...
Zfish   458 ---DSLVYRMIPPTSKNFLVNNLAAGTQYDLCVLAIYDD--GMTSLTATRVVGCVQ--------- 508

  Fly   545 FPLNVGVFPPPPEF--CSNIVPNPAFGGNIFIRVS---------------VTQDMLDGADLNMYP 592
                   |....|:  | :.:.:...||.:.|.:.               :...:.:..|.....
Zfish   509 -------FTTESEYLRC-HFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCNSGDAAKGT 565

  Fly   593 DLLNIPKRMQDVQ-------ESGAGAVAVPEGQ------FATLP------RHTARRGILKKDTSL 638
            .::::..:....|       .|..||:::.||:      .|.||      .||:...|....||
Zfish   566 SVIDVHSQTNGAQGCTVTPSASKQGALSLEEGEGGKKSSAAPLPPPPDSQTHTSETSIPDCSTS- 629

  Fly   639 QQQQQQHQQQHQHQQQQQQQQIQQQQHQQLQQQHQPSGLYTHDEIVTYNLEASGYDPHQSGYHSN 703
                                                          |..:..|...|..||
Zfish   630 ----------------------------------------------TSTVSQSWATPGSSG---- 644

  Fly   704 AMELPP---PPPPPAVTAV---------VQCHHPSPNNCASCINNA--PPPPSACQSPPVEVTPM 754
              .|.|   |.|.|..||.         .:..:.:.||..:....|  |||||..:..|: :...
Zfish   645 --SLKPKRKPAPKPVPTAEQPKAEVLPNAETQNTNRNNSTALYQPAPLPPPPSRFKDTPI-LRRA 706

  Fly   755 RPLDSSAYPKYDNM-------GRRITASGGLGGSNLSLH 786
            ||..|    ||..:       .||.:.:     .|||.|
Zfish   707 RPSTS----KYMTLPVEGAWAKRRYSLN-----ENLSKH 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	5/24 (21%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_4	144..186	CDD:289563	14/65 (22%)
		leucine-rich repeat	145..168	CDD:275380	8/46 (17%)
		leucine-rich repeat	169..216	CDD:275380	14/47 (30%)
		LRRCT	225..274	CDD:214507	14/48 (29%)
		Ig	295..367	CDD:143165	19/72 (26%)
lrfn5a	XP_001921674.1	leucine-rich repeat	53..76	CDD:275380	5/24 (21%)
		LRR_8	75..135	CDD:290566	19/59 (32%)
		leucine-rich repeat	77..100	CDD:275380	6/22 (27%)
		LRR_4	99..138	CDD:289563	14/38 (37%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		leucine-rich repeat	149..172	CDD:275380	0/22 (0%)
		LRR_8	155..207	CDD:290566	10/51 (20%)
		LRR_4	171..212	CDD:289563	12/40 (30%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		leucine-rich repeat	197..215	CDD:275380	5/17 (29%)
		TPKR_C2	240..>272	CDD:301599	10/35 (29%)
		I-set	287..374	CDD:254352	22/102 (22%)
		Ig_2	301..374	CDD:143241	21/87 (24%)
		fn3	421..494	CDD:278470	10/77 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6336
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910