DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and slitrk3

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_002933279.1	Gene:	slitrk3 / 100127669	XenbaseID:	XB-GENE-964617	Length:	885	Species:	Xenopus tropicalis

Alignment Length:	599	Identity:	122/599 - (20%)
Similarity:	226/599 - (37%)	Gaps:	162/599 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CASNCTCK--------WTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNREEFSTLGL 94
            |.:.|:|.        ..|.|:....:..:|  :|..|:.  :.|.||.|.|..:.|.:|.....
Frog   373 CPTGCSCSLHINDLGLTVNCKERGFHNISEL--LPRPLNA--KKLYLNGNLIQKIYRSDFWNFSS 433

  Fly    95 LNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLA 159
            |:|  ::|..:.:.|:.:.:|.||..|..:.|:.|.:|.|....|.|...|..||...|.::.:.
Frog   434 LDL--LHLGNNRISYVQEGAFVNLPNLKNLYLNGNDIERLTPGMFRGLQSLHYLYFEYNTIREIQ 496

  Fly   160 AYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNN-LLESLSEYVFQHMANLKTLSLE 223
            ...|.::|:|:.|.::|.|:..:...:.|..:|.. |||:|| .|......|.:|:..:..:.|.
Frog   497 PAAFSLMPNLKLLFLNDNLLRTLPTDTFAGTSLSR-LNLRNNHFLYLPVTGVLEHLNAIVQIDLN 560

  Fly   224 ENPWQCNCKLRKFRGWYVNSRLSSVSLV----CKGPPAQKDRTWDSVDDELFGCPPRVEIFNNEE 284
            :|||.|.|.:...:.|.  ..:|||.:|    |..|                      |...|::
Frog   561 QNPWDCTCDIVPLKQWI--ETISSVIVVGEVLCASP----------------------ENLTNKD 601

  Fly   285 VQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESESIASDKLWSNLTVFNVTSLDAG 349
            :::||:                        |:|..:  |.:||:.||..|..|:..
Frog   602 LKSIDM------------------------KVLCPE--LLDSEAAASPALPGNMVP--------- 631

  Fly   350 TYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMGIFGTVFLLISI-SFVVCLCKR 413
                |.|:.....|...:|.||.::             ..|::..|..||:...: :||:...|:
Frog   632 ----TSSSVFEFTTPGGAIPLSVLI-------------LSLLILFFSAVFVAAGLFAFVLRRRKK 679

  Fly   414 TT-RQHRHANKAGVKSSVS-FNDQEKKLLDSSVTTTTNDRGDSYGIDNQPTSIGMN------KGD 470
            .. |:.:..:..|::.... |.|::....:.:       .|..|.....|.:...|      :.:
Frog   680 LPFRKRQEVDLTGIQMQCRIFEDRQSNSPEKA-------PGHVYDYIPHPVTQMCNNPIYKPREE 737

  Fly   471 SAGMGFNQIEIHAVESHRHGSMLVQQQPQQQQVAGGGGMRQQLMQVKDSTCGMMSVPTSMAGHAH 535
            ..|..|::.:    |::.:...|::::            ::..|.|.:|....: |..:.:|...
Frog   738 EMGEQFSETK----ENNTNYRTLIEKE------------KEWTMAVSNSQLNTI-VTVNQSGDIP 785

  Fly   536 SHPAQISEEFPLNVGVFPPPPEFCSNIV----PNPAFGGNIFIRVSVTQDMLDGA-----DLNMY 591
            |        |..|..:||       .::    |.|..|   |:      |.|.|.     :|:::
Frog   786 S--------FHENGVIFP-------GVIDRERPAPTVG---FV------DCLYGTVPKLKELHVH 826

  Fly   592 PDLLNIPKRMQDVQ 605
            |..:..|...||.:
Frog   827 PPGMQYPDLQQDAR 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:290566	17/58 (29%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_4	144..186	CDD:289563	10/41 (24%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		leucine-rich repeat	169..216	CDD:275380	14/47 (30%)
		LRRCT	225..274	CDD:214507	12/52 (23%)
		Ig	295..367	CDD:143165	12/71 (17%)
slitrk3	XP_002933279.1	LRR_8	81..137	CDD:338972
		leucine-rich repeat	81..102	CDD:275380
		leucine-rich repeat	103..126	CDD:275380
		LRR_8	127..185	CDD:338972
		leucine-rich repeat	127..150	CDD:275380
		leucine-rich repeat	151..174	CDD:275380
		leucine-rich repeat	175..197	CDD:275380
		leucine-rich repeat	198..283	CDD:275380
		leucine-rich repeat	224..236	CDD:275378
		LRRCT	232..>270	CDD:214507
		LRR	<388..>562	CDD:227223	47/180 (26%)
		leucine-rich repeat	389..409	CDD:275380	4/21 (19%)
		leucine-rich repeat	410..433	CDD:275380	7/24 (29%)
		leucine-rich repeat	434..457	CDD:275380	7/24 (29%)
		LRR_8	457..516	CDD:338972	16/58 (28%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		leucine-rich repeat	482..505	CDD:275380	5/22 (23%)
		leucine-rich repeat	506..528	CDD:275380	5/21 (24%)
		leucine-rich repeat	529..553	CDD:275380	9/24 (38%)
		LRRCT	562..>597	CDD:214507	13/58 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910