Protein Alignment pasha and dgcr8

DIOPT Version :9

• Sequence 1: NP_001263150.1
• Gene: pasha / 43728
• FlyBaseID: FBgn0039861
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001116221.1
• Gene: dgcr8 / 563963
• ZFINID: ZDB-GENE-030131-3421
• Length: 782
• Species: Danio rerio
• Alignment Length: 679
• Identity: 243/679 - (35%)
• Similarity: 346/679 - (50%)
• Gaps: 115/679 - (16%)

  Fly    11 DSGQVRKRP-------RLEDEEQELKVAGFSLSAIEEMR----------------RTRDNELQNE 52
            ||.:.:.|.       ::.||:|.|:.....|.....||                |||: ||:.|
Zfish   117 DSSKSKDRKVLYTGFGQVSDEDQSLESINGELHDSVMMRSVPGSSAMSTGFMGLARTRE-ELEAE 180

  Fly    53 PMDQQLRQFQVLDEVGSGSDEDDESDNASEQQGGRYGEGGDE---------EEEAADGDGEEYDS 108
              .:...:|.|||      |.:|.|:|        :.|.|:.         ::|....:...|..
Zfish   181 --QENKVEFAVLD------DLEDFSEN--------FLEDGEPSAFRSQMIVQQEQVHEEDLSYSY 229

  Fly   109 SEFDDDEIENLLDEKLP-EELRESKQPKYE-----------------QRFKTVLEEKRLNHFEVL 155
            .|..|::::.||:|.:| .:.|...:.||.                 .:.||:|:.:.....|.|
Zfish   230 EEDFDNDVDALLEEGMPMPKKRRVAEDKYAGDSDHHSDGEAGVQPMMTKIKTILKSRGRPPTEPL 294

  Fly   156 PEGWVQVTHNSGMPLFLHRKTRVCCASRPYFLGTGSARKHAVPLGAIPCLNYRRALEEESEVEQQ 220
            |:||:...||||:|::|||:|||...||||||||||.|||..|..:||||:|::..|:|.  .:|
Zfish   295 PDGWIMTFHNSGIPVYLHRETRVVTWSRPYFLGTGSIRKHDPPTSSIPCLHYKKMKEQEE--REQ 357

  Fly   221 KTDGAPPVAVCPM-AGASALPAEAMDVEGKENNEGSTDSKTQPD--------------------G 264
            ..:..|...:.|: :|...:..|..|.......|..|...|..|                    |
Zfish   358 NGEVTPTAEISPVKSGEEGISLERADEPDSTATEEPTGRPTSEDPDLDLMEPGGSSIEGKDGQTG 422

  Fly   265 ITALMPAAKIVTVNENTQKESITPEQLNTYCQKLFKFKVIRVLRFRSWNARRKFTKN--RKHIKN 327
            .||.....::....|..:.|||..|...:|.:|.|.|:.:.|.:||:|..||:|.::  ||..::
Zfish   423 DTAQGALGQVKAKVEVCKDESIEIEDFRSYLEKCFDFEQVTVKKFRTWAERRQFNRDMKRKQAES 487

  Fly   328 IQRPTLPDGTKLIKFPILANAGEGSTNPRGRKEWIMNPNGKSFVCILHEYVQHALKTQPTYEFKE 392
             :||.||...|||...:        .:...:||:::||||||.|||||||:|..||.:|.|.|.|
Zfish   488 -ERPILPANQKLITLSV--------QDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFE 543

  Fly   393 LQNAATPYSATVSVNNLKYGTGYGTSKKQAKSEAARETLEILIPD-VKDKITGNNKDQKSGTAKK 456
            .:|.:.|:.|:|.::.:.||||..:|||.||::|||.|||||||| ||          ::...|.
Zfish   544 CENPSEPFGASVIIDGVTYGTGTASSKKLAKNKAARATLEILIPDFVK----------QTSEEKP 598

  Fly   457 AQSD-LSVFDDIRIEDPRVTEFCNKTTEPSPNAILLTCLQRNYG-SDVQISQEINRTANNKNEFT 519
            .:.| |..|:.|.|||.||.|..||....||..||..||:||:| .|..|..|:....|.|:|:.
Zfish   599 VEGDELEYFNHISIEDSRVYELTNKAGLLSPYQILHECLKRNHGMGDTSIKFEVIPGKNQKSEYV 663

  Fly   520 MTVGKHTAKVVCKNKREGKQLASQAILQILHPHIQTWGSLLRLYGNNSIKTFKEKKLEEQEITVL 584
            ||.||||.:..|||||.|||||||.|||:||||::.||||||:||..|.|..| |:..::.:..|
Zfish   664 MTCGKHTVRGWCKNKRVGKQLASQKILQMLHPHVKNWGSLLRMYGRESNKMVK-KENSDKSVIEL 727

  Fly   585 QSKAAVNQPNYAILDKLKSEMLKLCAKQE 613
            |..|..|:||..||:||:.||:||..::|
Zfish   728 QQYAKKNKPNLHILNKLREEMMKLARERE 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pasha	NP_001263150.1	DSRM	370..434	CDD:238007	33/63 (52%)
		DSRM	<514..549	CDD:214634	23/34 (68%)
dgcr8	NP_001116221.1	WW	293..323	CDD:197736	16/29 (55%)
		dsrm	522..585	CDD:278464	33/62 (53%)
		dsrm	629..693	CDD:278464	35/63 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593707
Domainoid	1	1.000	147	1.000	Domainoid score	I4465
eggNOG	1	0.900	-	-		E1_KOG4334
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11223
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2222
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367580at33208
OrthoFinder	1	1.000	-	-		FOG0007297
OrthoInspector	1	1.000	-	-		oto41092
orthoMCL	1	0.900	-	-		OOG6_107799
Panther	1	1.100	-	-	LDO	PTHR13482
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3423
SonicParanoid	1	1.000	-	-		X5401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790