DRSC/TRiP Functional Genomics Resources

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Protein Alignment pasha and DGCR8

DIOPT Version :9

Sequence 1:NP_001263150.1 Gene:pasha / 43728 FlyBaseID:FBgn0039861 Length:642 Species:Drosophila melanogaster
Sequence 2:NP_073557.3 Gene:DGCR8 / 54487 HGNCID:2847 Length:773 Species:Homo sapiens


Alignment Length:655 Identity:243/655 - (37%)
Similarity:350/655 - (53%) Gaps:90/655 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AEKPL-ADC-----PDSGQVRKRPRLEDEEQELKVAGFSLSAIEEMRRTRDNELQNEPMDQQLR- 59
            ||:.: |:|     |.||.|...|........:.:.|.|..     ::..:|||     ||:.| 
Human   140 AERDVRAECGLLLSPVSGDVHACPFGGSVGDGVGIGGESAD-----KKDEENEL-----DQEKRV 194

  Fly    60 QFQVLDEVGSGSDEDDESDNASEQQGGRYGEGGDEEEEAADGDGEEYDSSEFD-DDEIENLLDEK 123
            ::.||||:      :|.:||....:   .|.||...:.....|..:.::..|. :|:.:|.:|..
Human   195 EYAVLDEL------EDFTDNLELDE---EGAGGFTAKAIVQRDRVDEEALNFPYEDDFDNDVDAL 250

  Fly   124 LPEELRESKQPKYEQRF---------------------KTVLEEKRLNHFEVLPEGWVQVTHNSG 167
            |.|.|...|:.:.|:::                     ||||:.:.....|.||:||:...||||
Human   251 LEEGLCAPKKRRTEEKYGGDSDHPSDGETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSG 315

  Fly   168 MPLFLHRKTRVCCASRPYFLGTGSARKHAVPLGAIPCLNYRRALEEESEVEQQKTDGAPPVAVCP 232
            :|::|||::||...||||||||||.|||..||.:||||:|::.  :::|..:|.:|..|...|.|
Human   316 VPVYLHRESRVVTWSRPYFLGTGSIRKHDPPLSSIPCLHYKKM--KDNEEREQSSDLTPSGDVSP 378

  Fly   233 MAGAS-----ALPAEAMDVEGKENNEGSTDSKTQPDGITALMPA-----AKIVTVNENTQKESIT 287
            :...|     ..|.:..|..|.:  .|..|.| .|.|..|...|     ||:    |..:.||:.
Human   379 VKPLSRSAELEFPLDEPDSMGAD--PGPPDEK-DPLGAEAAPGALGQVKAKV----EVCKDESVD 436

  Fly   288 PEQLNTYCQKLFKFKVIRVLRFRSWNARRKFTK--NRKHIKNIQRPTLPDGTKLIKFPILANAGE 350
            .|:..:|.:|.|.|:.:.|.:||:|..||:|.:  .||..:: :||.||...|||...:      
Human   437 LEEFRSYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAES-ERPILPANQKLITLSV------ 494

  Fly   351 GSTNPRGRKEWIMNPNGKSFVCILHEYVQHALKTQPTYEFKELQNAATPYSATVSVNNLKYGTGY 415
              .:...:||:::||||||.|||||||:|..||.:|.|.|.|.:|.:.|:.|:|:::.:.||:|.
Human   495 --QDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGASVTIDGVTYGSGT 557

  Fly   416 GTSKKQAKSEAARETLEILIPD-VKDKITGNNKDQKSGTAKKAQSDLSVFDDIRIEDPRVTEFCN 479
            .:|||.||::|||.|||||||| ||         |.|....|...:|..|:.|.|||.||.|..:
Human   558 ASSKKLAKNKAARATLEILIPDFVK---------QTSEEKPKDSEELEYFNHISIEDSRVYELTS 613

  Fly   480 KTTEPSPNAILLTCLQRNYG-SDVQISQEINRTANNKNEFTMTVGKHTAKVVCKNKREGKQLASQ 543
            |....||..||..||:||:| .|..|..|:....|.|:|:.|..||||.:..|||||.|||||||
Human   614 KAGLLSPYQILHECLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQ 678

  Fly   544 AILQILHPHIQTWGSLLRLYGNNSIKTFKEKKLEEQEITVLQSKAAVNQPNYAILDKLKSEMLKL 608
            .|||:||||::.||||||:||..|.|..|: :..::.:..||..|..|:||..||.||:.||.:|
Human   679 KILQLLHPHVKNWGSLLRMYGRESSKMVKQ-ETSDKSVIELQQYAKKNKPNLHILSKLQEEMKRL 742

  Fly   609 CAKQE 613
            ..::|
Human   743 AEERE 747

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pashaNP_001263150.1 DSRM 370..434 CDD:238007 32/63 (51%)
DSRM <514..549 CDD:214634 22/34 (65%)
DGCR8NP_073557.3 Necessary for interaction with NCL. /evidence=ECO:0000269|PubMed:17765891 1..342 66/220 (30%)
Necessary for nuclear localization and retention 1..275 37/153 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..283 1/21 (5%)
Necessary for heme-binding and pri-miRNA processing 276..751 206/500 (41%)
WW 302..332 CDD:197736 15/29 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..414 15/56 (27%)
DSRM_DGCR8_rpt1 505..578 CDD:380696 40/72 (56%)
DSRM_DGCR8_rpt2 618..686 CDD:380697 36/67 (54%)
Interaction with DROSHA. /evidence=ECO:0000269|PubMed:26748718 701..773 17/48 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 742..773 2/6 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157904
Domainoid 1 1.000 151 1.000 Domainoid score I4365
eggNOG 1 0.900 - - E1_KOG4334
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H11223
Inparanoid 1 1.050 353 1.000 Inparanoid score I2263
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D367580at33208
OrthoFinder 1 1.000 - - FOG0007297
OrthoInspector 1 1.000 - - oto90696
orthoMCL 1 0.900 - - OOG6_107799
Panther 1 1.100 - - LDO PTHR13482
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3423
SonicParanoid 1 1.000 - - X5401
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.790

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