DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pasha and Dgcr8

DIOPT Version :9

Sequence 1:	NP_001263150.1	Gene:	pasha / 43728	FlyBaseID:	FBgn0039861	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001099335.1	Gene:	Dgcr8 / 287954	RGDID:	1306365	Length:	773	Species:	Rattus norvegicus

Alignment Length:	642	Identity:	244/642 - (38%)
Similarity:	342/642 - (53%)	Gaps:	93/642 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CPDSGQVRKRPRLEDEEQELKVAGFSLSAIEEMRRTRDNELQNEPMDQQLR-QFQVLDEVGSGSD 72
            ||..|.|..              |..|......::..:|||     ||:.| ::.||||:
  Rat   162 CPFGGSVGN--------------GVGLGGESTDKKDEENEL-----DQEKRVEYAVLDEL----- 202

  Fly    73 EDDESDNASEQQGGRYGEGGDEEEEAADGDGEEYDSSEFD-DDEIENLLDEKLPEELRESKQPKY 136
             :|.:||....:   .|.||.........|..:.::..|. :|:.:|.:|..|.|.|...|:.:.
  Rat   203 -EDFTDNLELDE---EGTGGFTANAIVQRDRVDEEALNFSYEDDFDNDVDALLEEGLCAPKKRRM 263

  Fly   137 EQRF---------------------KTVLEEKRLNHFEVLPEGWVQVTHNSGMPLFLHRKTRVCC 180
            |:::                     ||||:.:.....|.||:||:...||||:|::|||::||..
  Rat   264 EEKYGGDSDHPSDGETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVT 328

  Fly   181 ASRPYFLGTGSARKHAVPLGAIPCLNYRRALEEESEVEQQKTDGAPPVAVCPM--AGASA---LP 240
            .||||||||||.|||..||.:||||:|::.  :::|..:|..|.||...|.|:  .|.||   .|
  Rat   329 WSRPYFLGTGSIRKHDPPLSSIPCLHYKKM--KDNEEREQSCDLAPSGEVSPVKPLGRSAELDFP 391

  Fly   241 AEAMDVEGKENNEGSTDSKTQPDGITALMPA-----AKIVTVNENTQKESITPEQLNTYCQKLFK 300
            .|..|..|  .:.||.|.| .|.|..|...|     ||:    |..:.||:..|:...|.:|.|.
  Rat   392 LEEPDSLG--GDSGSLDEK-DPLGAEAAAGALGQVRAKV----EVCKDESVDLEEFRNYLEKRFD 449

  Fly   301 FKVIRVLRFRSWNARRKFTK--NRKHIKNIQRPTLPDGTKLIKFPILANAGEGSTNPRGRKEWIM 363
            |:.:.|.:||:|..||:|.:  .||..:: :||.||...|||...:        .:...:||:::
  Rat   450 FEQVTVKKFRTWAERRQFNREMKRKQAES-ERPILPANQKLITLSV--------QDAPTKKEFVI 505

  Fly   364 NPNGKSFVCILHEYVQHALKTQPTYEFKELQNAATPYSATVSVNNLKYGTGYGTSKKQAKSEAAR 428
            ||||||.|||||||:|..||.:|.|.|.|.:|.:.|:.|:|:::.:.||:|..:|||.||::|||
  Rat   506 NPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGASVTIDGVTYGSGTASSKKLAKNKAAR 570

  Fly   429 ETLEILIPD-VKDKITGNNKDQKSGTAKKAQSDLSVFDDIRIEDPRVTEFCNKTTEPSPNAILLT 492
            .|||||||| ||         |.|....|...:|..|:.|.|||.||.|..:|....||..||..
  Rat   571 ATLEILIPDFVK---------QTSEEKPKDSEELEYFNHISIEDSRVYELTSKAGLLSPYQILHE 626

  Fly   493 CLQRNYG-SDVQISQEINRTANNKNEFTMTVGKHTAKVVCKNKREGKQLASQAILQILHPHIQTW 556
            ||:||:| .|..|..|:....|.|:|:.|..||||.:..|||||.|||||||.|||:||||::.|
  Rat   627 CLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQLLHPHVKNW 691

  Fly   557 GSLLRLYGNNSIKTFKEKKLEEQEITVLQSKAAVNQPNYAILDKLKSEMLKLCAKQE 613
            |||||:||..|.|..|: :..::.:..||..|..|:||..||.||:.||.:|.|::|
  Rat   692 GSLLRMYGRESSKMVKQ-ETSDKSVIELQQYAKKNRPNLHILSKLQEEMKRLAAERE 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pasha	NP_001263150.1	DSRM	370..434	CDD:238007	32/63 (51%)
pasha	NP_001263150.1	DSRM	<514..549	CDD:214634	22/34 (65%)
Dgcr8	NP_001099335.1	WW	302..332	CDD:197736	15/29 (52%)
		DSRM_DGCR8_rpt1	505..578	CDD:380696	40/72 (56%)
		DSRM_DGCR8_rpt2	618..686	CDD:380697	36/67 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351902
Domainoid	1	1.000	157	1.000	Domainoid score	I4069
eggNOG	1	0.900	-	-		E1_KOG4334
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11223
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2138
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367580at33208
OrthoFinder	1	1.000	-	-		FOG0007297
OrthoInspector	1	1.000	-	-		oto97802
orthoMCL	1	0.900	-	-		OOG6_107799
Panther	1	1.100	-	-	LDO	PTHR13482
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760