Protein Alignment pasha and Dgcr8

DIOPT Version :10

• Sequence 1: NP_651879.1
• Gene: pasha / 43728
• FlyBaseID: FBgn0039861
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001099335.1
• Gene: Dgcr8 / 287954
• RGDID: 1306365
• Length: 773
• Species: Rattus norvegicus
• Alignment Length: 642
• Identity: 244/642 - (38%)
• Similarity: 342/642 - (53%)
• Gaps: 93/642 - (14%)

  Fly     9 CPDSGQVRKRPRLEDEEQELKVAGFSLSAIEEMRRTRDNELQNEPMDQQLR-QFQVLDEVGSGSD 72
            ||..|.|..              |..|......::..:|||     ||:.| ::.||||:
  Rat   162 CPFGGSVGN--------------GVGLGGESTDKKDEENEL-----DQEKRVEYAVLDEL----- 202

  Fly    73 EDDESDNASEQQGGRYGEGGDEEEEAADGDGEEYDSSEFD-DDEIENLLDEKLPEELRESKQPKY 136
             :|.:||....:   .|.||.........|..:.::..|. :|:.:|.:|..|.|.|...|:.:.
  Rat   203 -EDFTDNLELDE---EGTGGFTANAIVQRDRVDEEALNFSYEDDFDNDVDALLEEGLCAPKKRRM 263

  Fly   137 EQRF---------------------KTVLEEKRLNHFEVLPEGWVQVTHNSGMPLFLHRKTRVCC 180
            |:::                     ||||:.:.....|.||:||:...||||:|::|||::||..
  Rat   264 EEKYGGDSDHPSDGETSVQPMMTKIKTVLKSRGRPPTEPLPDGWIMTFHNSGVPVYLHRESRVVT 328

  Fly   181 ASRPYFLGTGSARKHAVPLGAIPCLNYRRALEEESEVEQQKTDGAPPVAVCPM--AGASA---LP 240
            .||||||||||.|||..||.:||||:|::.  :::|..:|..|.||...|.|:  .|.||   .|
  Rat   329 WSRPYFLGTGSIRKHDPPLSSIPCLHYKKM--KDNEEREQSCDLAPSGEVSPVKPLGRSAELDFP 391

  Fly   241 AEAMDVEGKENNEGSTDSKTQPDGITALMPA-----AKIVTVNENTQKESITPEQLNTYCQKLFK 300
            .|..|..|  .:.||.|.| .|.|..|...|     ||:    |..:.||:..|:...|.:|.|.
  Rat   392 LEEPDSLG--GDSGSLDEK-DPLGAEAAAGALGQVRAKV----EVCKDESVDLEEFRNYLEKRFD 449

  Fly   301 FKVIRVLRFRSWNARRKFTK--NRKHIKNIQRPTLPDGTKLIKFPILANAGEGSTNPRGRKEWIM 363
            |:.:.|.:||:|..||:|.:  .||..:: :||.||...|||...:        .:...:||:::
  Rat   450 FEQVTVKKFRTWAERRQFNREMKRKQAES-ERPILPANQKLITLSV--------QDAPTKKEFVI 505

  Fly   364 NPNGKSFVCILHEYVQHALKTQPTYEFKELQNAATPYSATVSVNNLKYGTGYGTSKKQAKSEAAR 428
            ||||||.|||||||:|..||.:|.|.|.|.:|.:.|:.|:|:::.:.||:|..:|||.||::|||
  Rat   506 NPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGASVTIDGVTYGSGTASSKKLAKNKAAR 570

  Fly   429 ETLEILIPD-VKDKITGNNKDQKSGTAKKAQSDLSVFDDIRIEDPRVTEFCNKTTEPSPNAILLT 492
            .|||||||| ||         |.|....|...:|..|:.|.|||.||.|..:|....||..||..
  Rat   571 ATLEILIPDFVK---------QTSEEKPKDSEELEYFNHISIEDSRVYELTSKAGLLSPYQILHE 626

  Fly   493 CLQRNYG-SDVQISQEINRTANNKNEFTMTVGKHTAKVVCKNKREGKQLASQAILQILHPHIQTW 556
            ||:||:| .|..|..|:....|.|:|:.|..||||.:..|||||.|||||||.|||:||||::.|
  Rat   627 CLKRNHGMGDTSIKFEVVPGKNQKSEYVMACGKHTVRGWCKNKRVGKQLASQKILQLLHPHVKNW 691

  Fly   557 GSLLRLYGNNSIKTFKEKKLEEQEITVLQSKAAVNQPNYAILDKLKSEMLKLCAKQE 613
            |||||:||..|.|..|: :..::.:..||..|..|:||..||.||:.||.:|.|::|
  Rat   692 GSLLRMYGRESSKMVKQ-ETSDKSVIELQQYAKKNRPNLHILSKLQEEMKRLAAERE 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pasha	NP_651879.1	WW	155..184	CDD:197736	15/28 (54%)
		DSRM_DGCR8_rpt1	363..436	CDD:380696	40/72 (56%)
		DSRM_DGCR8_rpt2	484..551	CDD:380697	36/67 (54%)
Dgcr8	NP_001099335.1	WW	302..332	CDD:197736	15/29 (52%)
		DSRM_DGCR8_rpt1	505..578	CDD:380696	40/72 (56%)
		DSRM_DGCR8_rpt2	618..686	CDD:380697	36/67 (54%)