DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pasha and dgcr8

DIOPT Version :9

Sequence 1:	NP_001263150.1	Gene:	pasha / 43728	FlyBaseID:	FBgn0039861	Length:	642	Species:	Drosophila melanogaster
Sequence 2:	NP_001153011.1	Gene:	dgcr8 / 100144670	XenbaseID:	XB-GENE-976035	Length:	772	Species:	Xenopus tropicalis

Alignment Length:	591	Identity:	224/591 - (37%)
Similarity:	329/591 - (55%)	Gaps:	58/591 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NEP-MDQQLR-QFQVLDEVGSGSDEDDESDNAS--EQQGGRYGEGGDEEEEAADGDGEEYD-SSE 110
            :|| :||:.: ::.||||:      :|.::|..  ::.|..:......:.:..|.:...|. ..|
Frog   186 DEPEIDQEKKVEYAVLDEL------EDFTENVMDVDEDGAEFVSESILQRDKIDEEALMYSYEDE 244

  Fly   111 FDDDEIENLLDEKLPEELRESKQPKYE-----------------QRFKTVLEEKRLNHFEVLPEG 158
            ||:| ::.||:|.|....:.....||:                 .:.||||:.:.....|.||:|
Frog   245 FDND-VDALLEESLHTPKKRRIDEKYDIDSDHQSDGESSVQPMVTKIKTVLKSRGRPPTEPLPDG 308

  Fly   159 WVQVTHNSGMPLFLHRKTRVCCASRPYFLGTGSARKHAVPLGAIPCLNYRRALEEESEVEQQKTD 223
            |:...||||:|::|||:|||...||||||||||.|||..|:.:||||:|::.  :::::::|..|
Frog   309 WIMTFHNSGLPVYLHRETRVVTWSRPYFLGTGSIRKHDPPISSIPCLHYKKM--KDNDIKEQSND 371

  Fly   224 GAPP-VAVCPMAGASAL--PAEAMDVEGKENNEGSTDSKTQPDGITALMPAAKIVTVNENTQKES 285
            .|.. ::|.|.|.:|..  .:|..|..|.::   ....:.:|....|.....::....|..:.||
Frog   372 VASAHISVSPSAKSSDANHHSEEPDSTGADS---FVSDEREPVSEAAQGALGQVKAKVEVCKDES 433

  Fly   286 ITPEQLNTYCQKLFKFKVIRVLRFRSWNARRKFTKNRKHIK-NIQRPTLPDGTKLIKFPILANAG 349
            |..|...:|.:|.|.|:.:.|.:||:|..||:|.:..|..: ..:||.||...|||...:
Frog   434 INLEDFRSYLEKRFDFEQVTVKKFRTWAERRQFNREMKRKQAECERPILPANQKLITLSV----- 493

  Fly   350 EGSTNPRGRKEWIMNPNGKSFVCILHEYVQHALKTQPTYEFKELQNAATPYSATVSVNNLKYGTG 414
               .:...:||:::||||||.|||||||:|..||.:|.|.|.|.:|.:.|:.|:|.::.:.||||
Frog   494 ---QDAPTKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGASVIIDGVTYGTG 555

  Fly   415 YGTSKKQAKSEAARETLEILIPD-VKDKITGNNKDQKSGTAKKAQSDLSVFDDIRIEDPRVTEFC 478
            ..:|||.||::|||.|||||||| ||.......||         ..:|..|:.|.|||.||.|..
Frog   556 TASSKKLAKNKAARATLEILIPDFVKQTCMEKPKD---------TDELEYFNHISIEDSRVYELT 611

  Fly   479 NKTTEPSPNAILLTCLQRNYG-SDVQISQEINRTANNKNEFTMTVGKHTAKVVCKNKREGKQLAS 542
            ||....||..||..||:||:| .|..|..|:....|.|:|:.||.||||.:..|||||.||||||
Frog   612 NKAGLLSPYQILHECLKRNHGMGDTSIKFEVIPGKNQKSEYVMTCGKHTVRGWCKNKRVGKQLAS 676

  Fly   543 QAILQILHPHIQTWGSLLRLYGNNSIKTFKEKKLEEQEITVLQSKAAVNQPNYAILDKLKSEMLK 607
            |.|||:||||::.||||||:||..|.|..|: :..::.:..||..|..|:||..||:||:.||.:
Frog   677 QKILQLLHPHVKNWGSLLRMYGRESSKIVKQ-ETSDKSVIELQQYAKKNKPNLHILNKLQEEMKR 740

  Fly   608 LCAKQE 613
            |..::|
Frog   741 LAQERE 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pasha	NP_001263150.1	DSRM	370..434	CDD:238007	33/63 (52%)
pasha	NP_001263150.1	DSRM	<514..549	CDD:214634	23/34 (68%)
dgcr8	NP_001153011.1	WW	304..334	CDD:197736	16/29 (55%)
		DSRM_DGCR8_rpt1	504..577	CDD:380696	41/72 (57%)
		DSRM_DGCR8_rpt2	617..685	CDD:380697	37/67 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I4371
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11223
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2193
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367580at33208
OrthoFinder	1	1.000	-	-		FOG0007297
OrthoInspector	1	1.000	-	-		oto104487
Panther	1	1.100	-	-	LDO	PTHR13482
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070