DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1792 and M1BP

DIOPT Version :9

Sequence 1:	NP_651878.1	Gene:	CG1792 / 43727	FlyBaseID:	FBgn0039860	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	118/414 - (28%)
Similarity:	178/414 - (42%)	Gaps:	84/414 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRTCGLFIFCSTPSNLFEEPNSVMLHQIEVLTGLFLLGGPGNE----LPPFICSPCELDLQTAIA 66
            ||.|..:........|||..|:.|:..||.||||.|      |    ||..||..|.::|.:|:.
  Fly    13 CRVCAKYASNKRSPKLFERSNTKMIDNIEALTGLRL------ENYGCLPDQICECCSMELASAVK 71

  Fly    67 FRERVIRTQKT----LQESPNLGNAELIESFAVGVE-----------------KEIQYAEEVTEI 110
            .|||.|..|:.    |.|....|.:....:..:|.:                 :||...|...||
  Fly    72 LRERCIAAQRELLLGLTEEQRQGISAFYRAAVMGEDIVQTVKTPDDDEVYATYQEIVLEEPKEEI 136

  Fly   111 EVIDL--------LPEEH--------LLEETEEPYEICEQNEQPQVKVPAQEKKLRRSTKTTPTV 159
            :...:        :.|.|        |:||.:....:.|..||.|.....::.:|.........|
  Fly   137 DDTKVEYDNTYYEVAEGHAGEDDAASLIEEADYDSIMAEDEEQQQTLELDEDTELIVGDVNDAYV 201

  Fly   160 FTS---VKFADNSQATRTQWSRLTEDEV----VALKR------------ERRKRDC----ICEQC 201
            :.|   |...||          :.:||.    :.:|:            :.|:|..    |||||
  Fly   202 YDSDDEVAVLDN----------VLDDEYEHENIVVKKCSLPPKPKVRSDDARRRGTGGVYICEQC 256

  Fly   202 GRHFTCPSNFKLHLLRHTGVKSFACDQCSQQFYTATLLRRHQELHAGNALFQCRYCEATYSNASG 266
            |.|......|:||..||.|.|.|.|:.|..:|.|.:.|:||...|.|...|.|:||...:::.:.
  Fly   257 GNHIKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTGERPFACKYCGRCFTDYTT 321

  Fly   267 RIQHERMRHTNVKPFTCKECNKSFAMSGKLRTHMLSHTGVRAFHCDSCQVSFVRRSHLTSHYRS- 330
            |::||| .|||.:|:.|..|.|:|.....|:.|||.|:|.||:.|:.|..||:..:||::|:||
  Fly   322 RVKHER-THTNERPYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLSTHFRSG 385

  Fly   331 --KGHAHTSSAQAALDNPVELDVK 352
              |.|...:..:..|:...:.::|
  Fly   386 VHKRHLEKAEMKQVLEQEQKRELK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1792	NP_651878.1	zf-AD	6..80	CDD:214871	29/81 (36%)
		C2H2 Zn finger	198..218	CDD:275368	9/19 (47%)
		C2H2 Zn finger	226..243	CDD:275368	6/16 (38%)
		C2H2 Zn finger	254..275	CDD:275368	7/20 (35%)
		zf-C2H2	281..303	CDD:278523	8/21 (38%)
		C2H2 Zn finger	283..303	CDD:275368	8/19 (42%)
		zf-H2C2_2	296..320	CDD:290200	12/23 (52%)
		C2H2 Zn finger	311..329	CDD:275368	7/17 (41%)
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871	28/76 (37%)
		C2H2 Zn finger	253..273	CDD:275368	9/19 (47%)
		COG5048	276..>331	CDD:227381	20/55 (36%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..317	CDD:290200	9/23 (39%)
		C2H2 Zn finger	309..329	CDD:275368	7/20 (35%)
		zf-H2C2_2	324..346	CDD:290200	11/22 (50%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	350..372	CDD:290200	10/21 (48%)
		C2H2 Zn finger	365..383	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447759
Domainoid	1	1.000	48	1.000	Domainoid score	I19075
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000724
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120097
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890