Protein Alignment Med and Smad9

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_620227.2
• Gene: Smad9 / 85435
• RGDID: 71004
• Length: 430
• Species: Rattus norvegicus
• Alignment Length: 720
• Identity: 208/720 - (28%)
• Similarity: 271/720 - (37%)
• Gaps: 323/720 - (44%)

  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQV 112
            |..|:..:||.|.|.:|::|::|||||||:|:..:|.|..|::..| .|||||||.|:|||||||
  Rat    18 VKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPG-QPSKCVTIPRSLDGRLQV 81

  Fly   113 AGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSL 176
            :.|||.|||||.|:||||||.. :|||.::.|.|.|..|...||:|||||.||.:|.:
  Rat    82 SHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVL------- 139

  Fly   177 QSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFP 241
               |..||.                      :|                 |||    ||..::..
  Rat   140 ---PPVLVP----------------------RH-----------------SEY----NPQLSLLA 158

  Fly   242 TGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLP-V 305
            ..|:                                                    |:.||.| :
  Rat   159 KFRS----------------------------------------------------ASLHSEPLM 171

  Fly   306 PHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQ 370
            ||                                      :.|.|.|.
  Rat   172 PH--------------------------------------NATYPDSF----------------- 181

  Fly   371 QQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSA 435
                |||                    .|..||
  Rat   182 ----QQS--------------------LGPAPP-------------------------------- 190

  Fly   436 GSAPVGGGGVFGTAQPTPQQPQQP-PTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPP 499
             |:|   |.||         ||.| ||                             :|.||.
  Rat   191 -SSP---GHVF---------PQSPCPT-----------------------------SYPQSP--- 210

  Fly   500 DPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKV 564
                              |||.::....|....:|.....   |.:|||:||:||:.:|||||:.
  Rat   211 ------------------GSPSESDSPYQHSDFRPVCYEE---PLHWCSVAYYELNNRVGETFQA 254

  Fly   565 PSAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDN 628
            .|.  :|:|||:.|||.. ||||||.||||:|....|..|.||||||.|...| |:|:..|:||:
  Rat   255 SSR--SVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECVSDS 316

  Fly   629 SVFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVA 692
            |:||||...:.:.|..|. .|.|| |:.| :|||              |.|..|...|.:|
  Rat   317 SIFVQSRNCNYQHGFHPA-TVCKI-PSGCSLKVF--------------NNQLFAQLLAQSV---- 361

  Fly   693 NQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDE 757
                 ..|..:       |.:|.::|.:|:|||||||.:|.||.:..||||||:|||..||.||:
  Rat   362 -----HHGFEV-------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDK 414

  Fly   758 VLHAM 762
            ||..|
  Rat   415 VLTQM 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	66/118 (56%)
		MH2_SMAD_4	543..760	CDD:199823	96/218 (44%)
Smad9	NP_620227.2	MH1_SMAD_1_5_9	13..136	CDD:199814	66/118 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..222		27/224 (12%)
		MH2	230..430	CDD:469593	98/228 (43%)