DRSC/TRiP Functional Genomics Resources

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Protein Alignment Med and Smad7

DIOPT Version :9

Sequence 1:NP_524610.1 Gene:Med / 43725 FlyBaseID:FBgn0011655 Length:771 Species:Drosophila melanogaster
Sequence 2:NP_110485.1 Gene:Smad7 / 81516 RGDID:69314 Length:426 Species:Rattus norvegicus


Alignment Length:454 Identity:106/454 - (23%)
Similarity:152/454 - (33%) Gaps:157/454 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   389 GGAAAGGQYYGQPPPVSQMQGAGGGGTS-----VAPSVHAQQNGYVSQPGSAGSAPVGG------ 442
            ||...||...|:.....:..||||||..     :..:|...:..:...|.|:|:...||      
  Rat    29 GGGGGGGDLRGEGATDGRAYGAGGGGAGRAGCCLGKAVRGAKGHHHPHPPSSGAGAAGGAEADLK 93

  Fly   443 -------------------------GGV--------------FGTAQPTPQQPQQPPTGVQ---- 464
                                     ||.              .|...|...||.|||:...    
  Rat    94 ALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPASAQPAQPPSSYSLPLL 158

  Fly   465 ----------------------ANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQ-PPDPRS-LP 505
                                  .:.|....:.        ....|:.|:....:: ||.|.| .|
  Rat   159 LCKVFRWPDLRHSSEVKRLCCCESYGKINPEL--------VCCNPHHLSRLCELESPPPPYSRYP 215

  Fly   506 GGFWNSSL--------SGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETF 562
            ..|...:.        |.:.|......|......|   ||.......:||.:||:|..|:||..:
  Rat   216 MDFLKPTADCPDAVPSSDETGGTNYLAPGGLSDSQ---LLLEPGDRSHWCVVAYWEEKTRVGRLY 277

  Fly   563 KV--PSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCL 625
            .|  ||      :|.:.|...||.||||.|::.::::..::.|..||.|:||....:| ||:...
  Rat   278 CVQEPS------LDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDG-VWVYNR 335

  Fly   626 SDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQC--------HQQMHSLATNAQAAAA 682
            |...:|::|..||....||.  .|||::|...||.||..:.        |:.|            
  Rat   336 SSYPIFIKSATLDNPDSRTL--LVHKVFPGFSIKAFDYEKAYSLQRPNDHEFM------------ 386

  Fly   683 AQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEV 746
                       ||...|                  ..:::|||||||..|.||.|...|||:||
  Rat   387 -----------QQPWTG------------------FTVQISFVKGWGQCYTRQFISSCPCWLEV 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MedNP_524610.1 MH1_SMAD_4 42..166 CDD:199816
MH2_SMAD_4 543..760 CDD:199823 65/214 (30%)
Smad7NP_110485.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 14..40 4/10 (40%)
MH1_SMAD_7 60..205 CDD:199818 18/152 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 67..88 4/20 (20%)
Important for interaction with SMURF2. /evidence=ECO:0000250 208..217 4/8 (50%)
PY-motif. /evidence=ECO:0000250 208..211 1/2 (50%)
MH2_SMAD_7 254..424 CDD:199825 65/218 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3701
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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