Protein Alignment Med and gb:cr929477

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: XP_009299441.1
• Gene: gb:cr929477 / 794669
• ZFINID: ZDB-GENE-141211-39
• Length: 505
• Species: Danio rerio
• Alignment Length: 741
• Identity: 364/741 - (49%)
• Similarity: 405/741 - (54%)
• Gaps: 249/741 - (33%)

  Fly    35 SNAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKC 99
            |:.|||.||||||||||||||||||||.|:||||||||||||||:||||||||||||||||||||
Zfish     4 SSTPTSNDACLSIVHSLMCHRQGGESESFSKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKC 68

  Fly   100 VTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERV 164
            ||||||||||||||||||||||||||:|||||||||||||||||.||||||||:|||||||||||
Zfish    69 VTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQFAFDLKCDNVCVNPYHYERV 133

  Fly   165 VSPGIDLSGLSLQS-GPS--RLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGP 226
            |||.||||.|:|.. |||  .:||:|:.......:.| .|:.|.||||..|          |..|
Zfish   134 VSPSIDLSVLTLGGPGPSGELMVKEEFEGQSSHSAAD-GGHSIQTIQHTAT----------PSAP 187

  Fly   227 SEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQ 291
                                                                             
Zfish   188 ----------------------------------------------------------------- 187

  Fly   292 QQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAM 356
                                 |...| .||:.||             ..||.:.| |...||:|
Zfish   188 ---------------------PDTFN-SPVLLPP-------------ADHTSSTS-TSAFSAMA- 215

  Fly   357 QQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSV 421
                                :|  ||.:                  |.|..:     |:|..||:
Zfish   216 --------------------AG--PNNA------------------PSSWPR-----GSSFPPSI 235

  Fly   422 HAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTG 486
             ..|||::.                       ..|..|.||..                   |:.
Zfish   236 -PHQNGHLQ-----------------------HHPPLPHTGQY-------------------WSV 257

  Fly   487 PNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAY 551
            .|.|.:    |||                                     :|..|.|:|||||||
Zfish   258 HNELAF----QPP-------------------------------------ISTHPAPDYWCSIAY 281

  Fly   552 FELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRG 616
            ||:|.||||||||||..|.|.:|||||||||:|||||.||||||||..|||||||||||||:.:|
Zfish   282 FEMDIQVGETFKVPSNCPVVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKG 346

  Fly   617 EGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAA 681
            |||||:|||||::||||||||||||||.||||||||||:|.||||||||||:||...|..|||||
Zfish   347 EGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAA 411

  Fly   682 AAQAAAVAG-VANQQMGGG---GRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPC 742
            ||||.|||| :......||   ..|::|||||||||||||||||:||||||||||||||||||||
Zfish   412 AAQADAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPC 476

  Fly   743 WIEVHLHRALQLLDEVLHAMPIDGPR 768
            |||:||||||||||||||.|||..|:
Zfish   477 WIEIHLHRALQLLDEVLHTMPISDPQ 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	117/123 (95%)
		MH2_SMAD_4	543..760	CDD:199823	175/220 (80%)
gb:cr929477	XP_009299441.1	MH1_SMAD_4	11..135	CDD:199816	117/123 (95%)
		MH2_SMAD_4	273..494	CDD:199823	175/220 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	344	1.000	Domainoid score	I1030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386709at33208
OrthoFinder	1	1.000	-	-		FOG0004851
OrthoInspector	1	1.000	-	-		otm26550
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920