DRSC/TRiP Functional Genomics Resources

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Protein Alignment Med and Smad5

DIOPT Version :9

Sequence 1:NP_524610.1 Gene:Med / 43725 FlyBaseID:FBgn0011655 Length:771 Species:Drosophila melanogaster
Sequence 2:NP_067724.1 Gene:Smad5 / 59328 RGDID:620158 Length:465 Species:Rattus norvegicus


Alignment Length:724 Identity:207/724 - (28%)
Similarity:279/724 - (38%) Gaps:293/724 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQV 112
            |..|:..:||.|.|.:|::|:::||||||:|:..::.|..|:::.| .|||||||.|:|||||||
  Rat    15 VKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG-QPSKCVTIPRSLDGRLQV 78

  Fly   113 AGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSL 176
            :.|||.|||||.|:||||||.. :|||.:..|.|.|..|...||:|||||:||.||.:       
  Rat    79 SHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVL------- 136

  Fly   177 QSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFP 241
               |..||.                      :|:                     :.||..::..
  Rat   137 ---PPVLVP----------------------RHN---------------------EFNPQHSLLV 155

  Fly   242 TGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVP 306
            ..|.:...||                           ..||..| .|....|..|          
  Rat   156 QFRNLSHNEP---------------------------HMPQNAT-FPDSFHQPNS---------- 182

  Fly   307 HGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQ 371
                 .|.|::|                          |||..|:.|                  
  Rat   183 -----TPFPLSP--------------------------NSPYPPSPA------------------ 198

  Fly   372 QQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAG 436
                 |...||...::|                                           |||..
  Rat   199 -----SSTYPNSPASSG-------------------------------------------PGSPF 215

  Fly   437 SAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDP 501
            ..|.          .||     ||                                  :..||| 
  Rat   216 QLPA----------DTP-----PP----------------------------------AYMPPD- 230

  Fly   502 RSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSR--QP----PPEYWCSIAYFELDTQVGE 560
                     ..:..|...|..| ......|..|.:.||  ||    .|::||||.|:||:.:|||
  Rat   231 ---------DQMGQDNSQPMDT-SNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGE 285

  Fly   561 TFKVPSAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRC 624
            .|...|.  :|::||:.||:.. :|||||.||||:|....|..|.||||||.|...| |:|:..|
  Rat   286 AFHASST--SVLVDGFTDPANNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAEC 347

  Fly   625 LSDNSVFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLATNAQAAAAAQAAAV 688
            |||:|:||||...:...|..| ..|.|| |::| :|:|:    :|:.            ||..| 
  Rat   348 LSDSSIFVQSRNCNFHHGFHP-TTVCKI-PSSCSLKIFN----NQEF------------AQLLA- 393

  Fly   689 AGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQ 753
                 |.:..|..:        |.:|.::|.:|:|||||||.:|.||.:..||||||:|||..||
  Rat   394 -----QSVNHGFEA--------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQ 445

  Fly   754 LLDEVLHAM 762
            .||:||..|
  Rat   446 WLDKVLTQM 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MedNP_524610.1 MH1_SMAD_4 42..166 CDD:199816 64/118 (54%)
MH2_SMAD_4 543..760 CDD:199823 92/218 (42%)
Smad5NP_067724.1 MH1_SMAD_1_5_9 10..133 CDD:199814 64/118 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..243 33/273 (12%)
MH2_SMAD_1_5_9 265..465 CDD:199822 94/225 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3701
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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