Protein Alignment Med and Smad5

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_067724.1
• Gene: Smad5 / 59328
• RGDID: 620158
• Length: 465
• Species: Rattus norvegicus
• Alignment Length: 724
• Identity: 207/724 - (28%)
• Similarity: 279/724 - (38%)
• Gaps: 293/724 - (40%)

  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQV 112
            |..|:..:||.|.|.:|::|:::||||||:|:..::.|..|:::.| .|||||||.|:|||||||
  Rat    15 VKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG-QPSKCVTIPRSLDGRLQV 78

  Fly   113 AGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSL 176
            :.|||.|||||.|:||||||.. :|||.:..|.|.|..|...||:|||||:||.||.:
  Rat    79 SHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVL------- 136

  Fly   177 QSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFP 241
               |..||.                      :|:                     :.||..::..
  Rat   137 ---PPVLVP----------------------RHN---------------------EFNPQHSLLV 155

  Fly   242 TGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVP 306
            ..|.:...||                           ..||..| .|....|..|
  Rat   156 QFRNLSHNEP---------------------------HMPQNAT-FPDSFHQPNS---------- 182

  Fly   307 HGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQ 371
                 .|.|::|                          |||..|:.|
  Rat   183 -----TPFPLSP--------------------------NSPYPPSPA------------------ 198

  Fly   372 QQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAG 436
                 |...||...::|                                           |||..
  Rat   199 -----SSTYPNSPASSG-------------------------------------------PGSPF 215

  Fly   437 SAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDP 501
            ..|.          .||     ||                                  :..|||
  Rat   216 QLPA----------DTP-----PP----------------------------------AYMPPD- 230

  Fly   502 RSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSR--QP----PPEYWCSIAYFELDTQVGE 560
                     ..:..|...|..| ......|..|.:.||  ||    .|::||||.|:||:.:|||
  Rat   231 ---------DQMGQDNSQPMDT-SNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGE 285

  Fly   561 TFKVPSAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRC 624
            .|...|.  :|::||:.||:.. :|||||.||||:|....|..|.||||||.|...| |:|:..|
  Rat   286 AFHASST--SVLVDGFTDPANNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAEC 347

  Fly   625 LSDNSVFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLATNAQAAAAAQAAAV 688
            |||:|:||||...:...|..| ..|.|| |::| :|:|:    :|:.            ||..|
  Rat   348 LSDSSIFVQSRNCNFHHGFHP-TTVCKI-PSSCSLKIFN----NQEF------------AQLLA- 393

  Fly   689 AGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQ 753
                 |.:..|..:        |.:|.::|.:|:|||||||.:|.||.:..||||||:|||..||
  Rat   394 -----QSVNHGFEA--------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQ 445

  Fly   754 LLDEVLHAM 762
            .||:||..|
  Rat   446 WLDKVLTQM 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	64/118 (54%)
		MH2_SMAD_4	543..760	CDD:199823	92/218 (42%)
Smad5	NP_067724.1	MH1_SMAD_1_5_9	10..133	CDD:199814	64/118 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..243		33/273 (12%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	94/225 (42%)