Protein Alignment Med and smad3a

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_571646.1
• Gene: smad3a / 58092
• ZFINID: ZDB-GENE-000509-3
• Length: 425
• Species: Danio rerio
• Alignment Length: 716
• Identity: 197/716 - (27%)
• Similarity: 264/716 - (36%)
• Gaps: 332/716 - (46%)

  Fly    56 QGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPH 120
            |.|:.|.:.::|::||||||| |..:||.|..||||...: :||:||.|:|||||||:.|||.||
Zfish    22 QNGQEEKWCEKAVKSLVKKLK-KTGQLDELEKAITTQDVN-TKCITIPRSLDGRLQVSHRKGLPH 84

  Fly   121 VIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSLQSGPSRLV 184
            |||.|:||||||.. :||:.::.|.|||.:|.|.||||||||:||.:|.:          |..||
Zfish    85 VIYCRLWRWPDLQSHHELRAIELCEFAFHMKKDEVCVNPYHYQRVETPVL----------PPVLV 139

  Fly   185 KDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKI 249
            .                      :|  |::           |||:
Zfish   140 P----------------------RH--TEI-----------PSEF-------------------- 149

  Fly   250 EPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLP----VPHGMP 310
                                   ||....                     :||:|    .|.|:
Zfish   150 -----------------------PPLDDY---------------------SHSIPENTIFPAGI- 169

  Fly   311 GMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQ 375
                                  .||.|.:..|
Zfish   170 ----------------------EPQSNYIPET--------------------------------- 179

  Fly   376 QSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPV 440
                                     |||                       ||:|:.|.....
Zfish   180 -------------------------PPP-----------------------GYISEDGETSDH-- 194

  Fly   441 GGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLP 505
                                   |.|                                   ||:
Zfish   195 -----------------------QMN-----------------------------------RSM- 200

  Fly   506 GGFWNSSLSGDLGSPQQTP----PQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPS 566
                      |.|||..:|    |.......||.....   |.:||||:|:||:.:|||||.  :
Zfish   201 ----------DTGSPNLSPNPVSPAHNNLDLQPVTYCE---PAFWCSISYYELNQRVGETFH--A 250

  Fly   567 AKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVF 631
            ::|::.:||:.|||...|||||.||||:|....|..|.|||:||:|...| |:|:..||||:::|
Zfish   251 SQPSLTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG-GEVFAECLSDSAIF 314

  Fly   632 VQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQM 696
            |||...::..|..|. .|.||.|...:|:|              |.|..||..|.:|    ||..
Zfish   315 VQSPNCNQRYGWHPA-TVCKIPPGCNLKIF--------------NNQEFAALLAQSV----NQGF 360

  Fly   697 GGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHA 761
            .            .|..|.|:|.:|:|||||||.:|.||::..||||||:||:..||.||:||..
Zfish   361 E------------AVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQ 413

  Fly   762 M 762
            |
Zfish   414 M 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	64/110 (58%)
		MH2_SMAD_4	543..760	CDD:199823	92/216 (43%)
smad3a	NP_571646.1	MH1_SMAD_2_3	7..131	CDD:199815	64/110 (58%)
		MH2_SMAD_2_3	224..414	CDD:199826	93/226 (41%)