Protein Alignment Med and smad6b

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001038516.1
• Gene: smad6b / 564395
• ZFINID: ZDB-GENE-050419-198
• Length: 486
• Species: Danio rerio
• Alignment Length: 745
• Identity: 138/745 - (18%)
• Similarity: 200/745 - (26%)
• Gaps: 410/745 - (55%)

  Fly    31 PPPPSNAPTSADACLSIVHSLMCHRQGG-----ES------EGFAKRAIESLVKKLKEKRDELDS 84
            |.|.|        |..::.::...|..|     ||      |...|.|..||:|:||||  .||:
Zfish   127 PEPGS--------CQFVLRNIGSSRDPGPLESQESKPRSVMEQELKTATYSLLKRLKEK--TLDT 181

  Fly    85 LITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDL-HKNELKHVKYCAFAFD 148
            |:.|:.:.|. ||.||.:.||   .|::.|....|.::..:::||.|| |..:||.:  |
Zfish   182 LLEAVESGGM-PSDCVMVSRT---ELRLGGHMAPPQLLICKLYRWSDLQHTAQLKAL--C----- 235

  Fly   149 LKCDS--------VCVNPYHYERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIG 205
             :|.|        ||.|||||.|:..|
Zfish   236 -ECKSFGAQDGPVVCCNPYHYSRLCGP-------------------------------------- 261

  Fly   206 TIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRL 270
                                                                             
Zfish   262 ----------------------------------------------------------------- 261

  Fly   271 GQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQ 335
                                                                ..||||....:|
Zfish   262 ----------------------------------------------------ESPPPPYSRLSP- 273

  Fly   336 GNGVHHTQANSPTDPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQ 400
                  ::.:.|.|
Zfish   274 ------SEEHKPLD--------------------------------------------------- 281

  Fly   401 PPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQA 465
                                                                             
Zfish   282 ----------------------------------------------------------------- 281

  Fly   466 NTGSAGAQAGAGGGAAGTWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQ 530
                               ...:||:||::.....|.:..|.|.::|||.|  :|:|:
Zfish   282 -------------------LSDSTLSYTETEAASSPNATQGEFSDASLSPD--APKQS------- 318

  Fly   531 QQQPRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHR 595
                          :||::||:|..|:||..:.|  .:|.|.|  :.|...|..||||.||...|
Zfish   319 --------------HWCNVAYWEHRTRVGRLYTV--YQPAVSI--FYDLPQGTGFCLGQLSLDQR 365

  Fly   596 TEQSERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGD---AVHKIYPAAC 657
            :...:|.|..||.|:.|....:| ||....|.:.:||.|..||     .||.   .|.|:.|...
Zfish   366 SSTVQRTRGKIGYGLLLSKEPDG-VWAYNRSQHPIFVNSPTLD-----VPGSRSLVVRKVMPGYS 424

  Fly   658 IKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRL 722
            |||||..:          ::.....|::..:.|..:...                       :|:
Zfish   425 IKVFDYER----------SSMLRQGAESELLDGPYDPNS-----------------------VRI 456

  Fly   723 SFVKGWGPDYPRQSIKETPCWIEVHL--HR 750
            ||.|||||.|.||.|...|||:|:.|  ||
Zfish   457 SFAKGWGPCYSRQFITSCPCWLEILLNNHR 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	47/143 (33%)
		MH2_SMAD_4	543..760	CDD:199823	67/213 (31%)
smad6b	NP_001038516.1	MH1_SMAD_6	152..262	CDD:199817	45/278 (16%)
		MH2_SMAD_6	311..484	CDD:199824	69/238 (29%)