DRSC/TRiP Functional Genomics Resources

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Protein Alignment Med and smad10a

DIOPT Version :9

Sequence 1:NP_524610.1 Gene:Med / 43725 FlyBaseID:FBgn0011655 Length:771 Species:Drosophila melanogaster
Sequence 2:NP_001352568.1 Gene:smad10a / 560317 ZFINID:ZDB-GENE-060503-248 Length:581 Species:Danio rerio


Alignment Length:761 Identity:382/761 - (50%)
Similarity:425/761 - (55%) Gaps:210/761 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 NAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCV 100
            |.|.|.||||||||||||||||||:||||||||||||||||||:||||||||||||||.||||||
Zfish     4 NPPNSNDACLSIVHSLMCHRQGGENEGFAKRAIESLVKKLKEKKDELDSLITAITTNGVHPSKCV 68

  Fly   101 TIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERVV 165
            |||||||||||||||||||||||||:|||||||||||||||:|.:|||||.|:||||||||||||
Zfish    69 TIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKFCQYAFDLKYDNVCVNPYHYERVV 133

  Fly   166 SPGIDLSGLSLQS-----------GPS-RLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPG 218
            ||||  .|||||:           ||: ||:|:|||                   |...||..| 
Zfish   134 SPGI--VGLSLQNTETHLSSGRCLGPTGRLIKEEYS-------------------HDCIQMDVP- 176

  Fly   219 GYGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQ 283
                                        |.:.||.   ..:|:..:|||...|||      .|..
Zfish   177 ----------------------------PGLPPQQ---DHQGAMKLPPPDHYGQP------LPPL 204

  Fly   284 QTPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPT 348
            |.|                              :.|| .||||....:..|.          |||
Zfish   205 QLP------------------------------SEGP-RAPPPVTLYSNMPL----------SPT 228

  Fly   349 DPASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGG 413
            ...|.:.||                                                     ||.
Zfish   229 ASGSMMPMQ-----------------------------------------------------GGH 240

  Fly   414 GTSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGG 478
            |..:...  |...|.|..|....|.|..|      ...||..||.||   ..|..::...:...|
Zfish   241 GEGLLQI--ASPQGQVMTPTPPPSTPTHG------PPQTPVPPQPPP---NQNGYNSSKHSQTQG 294

  Fly   479 GAAGTWTGPNTLTYT--------QSMQPP--DPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQ 533
            ....||||.:|.:||        :..|||  .|.     ||:...|    |....||        
Zfish   295 SFHTTWTGSSTASYTPVGPQQNGRGHQPPLHHPH-----FWSQHHS----SASFPPP-------- 342

  Fly   534 PRLLSRQPPPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQ 598
               :|..|.||:||||:|||:|.||||.|||.|:.|.|.||||||||||:|||||.|||||||:.
Zfish   343 ---VSNHPGPEFWCSISYFEMDVQVGEMFKVLSSCPVVTIDGYVDPSGGDRFCLGQLSNVHRTDA 404

  Fly   599 SERARLHIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDL 663
            ||||||||||||||:.|||||||:||:||::||||||||||||||.||||||||||.|.||||||
Zfish   405 SERARLHIGKGVQLECRGEGDVWMRCMSDHAVFVQSYYLDREAGRAPGDAVHKIYPGAYIKVFDL 469

  Fly   664 RQCHQQMHSLATNAQAAAAAQAAAVAG-VANQQMGGG---GRSMTAAAGIGVDDLRRLCILRLSF 724
            ||||:||...|..|||||||||||||| :......||   ..|::||||||||||||||||||||
Zfish   470 RQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAVSLSAAAGIGVDDLRRLCILRLSF 534

  Fly   725 VKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHAMPIDGPRAA 770
            ||||||||||||||.||||:||||||||||||||||.||:..|..|
Zfish   535 VKGWGPDYPRQSIKHTPCWVEVHLHRALQLLDEVLHTMPLADPGPA 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MedNP_524610.1 MH1_SMAD_4 42..166 CDD:199816 114/123 (93%)
MH2_SMAD_4 543..760 CDD:199823 174/220 (79%)
smad10aNP_001352568.1 MH1_SMAD_4 10..134 CDD:199816 114/123 (93%)
MH2_SMAD_4 349..570 CDD:199823 174/220 (79%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170576817
Domainoid 1 1.000 344 1.000 Domainoid score I1030
eggNOG 1 0.900 - - E1_KOG3701
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 393 1.000 Inparanoid score I1928
OMA 1 1.010 - - QHG48996
OrthoDB 1 1.010 - - D386709at33208
OrthoFinder 1 1.000 - - FOG0004851
OrthoInspector 1 1.000 - - otm26550
orthoMCL 1 0.900 - - OOG6_105347
Panther 1 1.100 - - O PTHR13703
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5008
SonicParanoid 1 1.000 - - X3979
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1615.800

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