Protein Alignment Med and Smad9

DIOPT Version :9

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: XP_036019060.1
• Gene: Smad9 / 55994
• MGIID: 1859993
• Length: 456
• Species: Mus musculus
• Alignment Length: 729
• Identity: 204/729 - (27%)
• Similarity: 266/729 - (36%)
• Gaps: 325/729 - (44%)

  Fly    39 TSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQ 103
            ||.|:  ..|..|:..:||.|.|.:|::|::|||||||:|:..:|.|..|::..| .|||||||.
Mouse    37 TSVDS--PAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPG-QPSKCVTIP 98

  Fly   104 RTLDGRLQVAGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSP 167
            |:|||||||:.|||.|||||.|:||||||.. :|||.::.|.|.|..|...||:|||||.||.:|
Mouse    99 RSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETP 163

  Fly   168 GIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGD 232
            .:          |..||.                      :|                 |||
Mouse   164 VL----------PPVLVP----------------------RH-----------------SEY--- 176

  Fly   233 ANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQ 297
             ||..::....|:
Mouse   177 -NPQLSLLAKFRS---------------------------------------------------- 188

  Fly   298 AAAHSLP-VPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQ 361
            |:.||.| :||... .|.........|||..|
Mouse   189 ASLHSEPLMPHNAT-YPDSFQQSLCPAPPSSP--------------------------------- 219

  Fly   362 QQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQN 426
                                                                             
Mouse   220 ----------------------------------------------------------------- 219

  Fly   427 GYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQP-PTGVQANTGSAGAQAGAGGGAAGTWTGPNTL 490
                            |.||         ||.| ||.
Mouse   220 ----------------GHVF---------PQSPCPTS---------------------------- 231

  Fly   491 TYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELD 555
                  .|..|                |||.::....|....:|.....   |::|||:||:||:
Mouse   232 ------YPHSP----------------GSPSESDSPYQHSDFRPVCYEE---PQHWCSVAYYELN 271

  Fly   556 TQVGETFKVPSAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGD 619
            .:|||||:..|.  :|:|||:.|||.. ||||||.||||:|....|..|.||||||.|...| |:
Mouse   272 NRVGETFQASSR--SVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GE 333

  Fly   620 VWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQQMHSLATNAQAAAAA 683
            |:..|:||:|:||||...:.:.|..|. .|.|| |:.| :|||              |.|..|..
Mouse   334 VYAECVSDSSIFVQSRNCNYQHGFHPA-TVCKI-PSGCSLKVF--------------NNQLFAQL 382

  Fly   684 QAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHL 748
            .|.:|         ..|..:       |.:|.::|.:|:|||||||.:|.||.:..||||||:||
Mouse   383 LAQSV---------HHGFEV-------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL 431

  Fly   749 HRALQLLDEVLHAM 762
            |..||.||:||..|
Mouse   432 HGPLQWLDKVLTQM 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	67/124 (54%)
		MH2_SMAD_4	543..760	CDD:199823	96/218 (44%)
Smad9	XP_036019060.1	MH1_SMAD_1_5_9	41..162	CDD:199814	66/123 (54%)
		MH2	256..456	CDD:412135	98/228 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810