Protein Alignment Med and smad4a

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: XP_017213465.1
• Gene: smad4a / 559111
• ZFINID: ZDB-GENE-990603-8
• Length: 548
• Species: Danio rerio
• Alignment Length: 747
• Identity: 373/747 - (49%)
• Similarity: 415/747 - (55%)
• Gaps: 220/747 - (29%)

  Fly    35 SNAPTSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKC 99
            :|.|||.||||||||||||||||||||.||||||||||||||||:||||||||||||||||||||
Zfish     4 TNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKC 68

  Fly   100 VTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCAFAFDLKCDSVCVNPYHYERV 164
            ||||||||||||||||||||||||||:|||||||||||||||||.||||||||||||||||||||
Zfish    69 VTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQFAFDLKCDSVCVNPYHYERV 133

  Fly   165 VSPGIDLSGLSLQ-SGPSRL-VKDEYSAGPLVGSMDIDG--------NDIGTIQHHPTQMVGPGG 219
            ||||||||||:|. ||||.| |||||         |.||        ..:.||||.|::.|
Zfish   134 VSPGIDLSGLTLSGSGPSGLMVKDEY---------DYDGPPSLPSTEGHMQTIQHPPSRAV---- 185

  Fly   220 YGYPQGPSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQ 284
               .|.|             |.|...:|
Zfish   186 ---TQEP-------------FSTPALLP------------------------------------- 197

  Fly   285 TPQPTQQQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTD 349
               |.:...:.|.:|..|:.|                                       .|.|.
Zfish   198 ---PAEGSSSASSSAFSSIAV---------------------------------------GSTTQ 220

  Fly   350 PASALAMQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGG 414
            |.|.|:.........|......|..||: |.|.|..:.         |:..|      ..:....
Zfish   221 PGSVLSGSHSSDSLLQIASGTGQGSQQN-GFPPGQTST---------YHHNP------TSSWSRN 269

  Fly   415 TSVAPSVHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGG 479
            ::..|||...|||:
Zfish   270 SNFTPSVPHHQNGH--------------------------------------------------- 283

  Fly   480 AAGTWTGPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPE 544
                            :|...|.:.|..:|               |...:...||.:.:....||
Zfish   284 ----------------LQHHPPMAHPAHYW---------------PVHNEIAFQPPISNHPAAPE 317

  Fly   545 YWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKG 609
            |||||||||:|.||||||||||:.|.|.:|||||||||:|||||.||||||||..||||||||||
Zfish   318 YWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKG 382

  Fly   610 VQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLA 674
            |||:.:||||||:|||||::||||||||||||||.||||||||||:|.||||||||||:||...|
Zfish   383 VQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQA 447

  Fly   675 TNAQAAAAAQAAAVAG-VANQQMGGG---GRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQ 735
            ..|||||||||||||| :......||   ..|::|||||||||||||||||:|||||||||||||
Zfish   448 ATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQ 512

  Fly   736 SIKETPCWIEVHLHRALQLLDEVLHAMPIDGP 767
            ||||||||||:||||||||||||||.|||..|
Zfish   513 SIKETPCWIEIHLHRALQLLDEVLHTMPIADP 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	119/123 (97%)
		MH2_SMAD_4	543..760	CDD:199823	177/220 (80%)
smad4a	XP_017213465.1	MH1_SMAD_4	11..135	CDD:199816	119/123 (97%)
		PAT1	<164..>314	CDD:401645	43/346 (12%)
		MH2_SMAD_4	316..537	CDD:199823	177/220 (80%)