Protein Alignment Med and smad9

DIOPT Version :10

• Sequence 1: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0288966
• Length: 771
• Species: Drosophila melanogaster
• Sequence 2: NP_001315428.1
• Gene: smad9 / 445564
• ZFINID: ZDB-GENE-031014-1
• Length: 466
• Species: Danio rerio
• Alignment Length: 744
• Identity: 209/744 - (28%)
• Similarity: 288/744 - (38%)
• Gaps: 307/744 - (41%)

  Fly    36 NAPTSADACLSI----VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHP 96
            ::.||..:..|.    |..|:..:||.|.|.:|::|::|||||||:|:..::.|..|::..| .|
Zfish     2 HSSTSITSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMEELEKALSCPG-QP 65

  Fly    97 SKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYH 160
            ||||||.|:|||||||:.|||.|||||.|:||||||.. :|||.:..|.|.|..|...:|:||||
Zfish    66 SKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKALDCCEFPFGSKQKEICINPYH 130

  Fly   161 YERVVSPGIDLSGLSLQSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQG 225
            |.||.:|.:          |..||.                      :|
Zfish   131 YRRVETPVL----------PPVLVP----------------------RH---------------- 147

  Fly   226 PSEYVGDANPMSAMFPTGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQ 290
             ||:    ||..::....|
Zfish   148 -SEF----NPQHSLLAKFR---------------------------------------------- 161

  Fly   291 QQQAQSQAAAHSLPVPHGMPGMPGPMNPGPVMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALA 355
                  .|:.|:.|:                     .||.|..|.         :.|..|.|:.:
Zfish   162 ------NASLHNEPL---------------------MPQNATFPD---------SFPAMPCSSFS 190

  Fly   356 MQQQQQQQQQQQQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPS 420
            ..                       |:.|:|.                              :|:
Zfish   191 SS-----------------------PSSSLNP------------------------------SPA 202

  Fly   421 VHAQQNGYVSQPGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWT 485
            .|       |.|.|..||            ..|..|.|    :.|.|
Zfish   203 AH-------SFPNSPSSA------------TEPGSPYQ----ITAET------------------ 226

  Fly   486 GPNTLTYTQSMQPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQP--------- 541
                        ||.|.|:    ..||.|.|:         :..:..:.:|:...|
Zfish   227 ------------PPPPYSM----MESSPSEDV---------KPAESSENKLILTAPQRDLRPVCY 266

  Fly   542 -PPEYWCSIAYFELDTQVGETFKVPSAKPNVIIDGYVDPSGG-NRFCLGALSNVHRTEQSERARL 604
             .||||||:||:||:.:|||||.. ||: ::::||:.|||.. ||||||.||||:|....|..|.
Zfish   267 EEPEYWCSVAYYELNNRVGETFHA-SAR-SILVDGFTDPSNNKNRFCLGLLSNVNRNSTIEHTRR 329

  Fly   605 HIGKGVQLDLRGEGDVWLRCLSDNSVFVQSYYLDREAGRTPGDAVHKIYPAAC-IKVFDLRQCHQ 668
            ||||||.|...| |:|:..||||:|:||||...:.:.|..| ..|.|| |:.| :|:|: .|...
Zfish   330 HIGKGVHLYYVG-GEVYAECLSDSSIFVQSRNCNYQHGFHP-TTVCKI-PSGCSLKIFN-NQLFA 390

  Fly   669 QMHSLATNAQAAAAAQAAAVAGVANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYP 733
            |:.|.:.|.....                             |.:|.::|.:|:|||||||.:|.
Zfish   391 QLLSQSVNHGFEV-----------------------------VYELTKMCTIRMSFVKGWGAEYH 426

  Fly   734 RQSIKETPCWIEVHLHRALQLLDEVLHAM 762
            ||.:..||||||:|||..||.||:||..|
Zfish   427 RQDVTSTPCWIEIHLHGPLQWLDKVLTQM 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	65/128 (51%)
		MH2_SMAD_4	543..760	CDD:199823	95/218 (44%)
smad9	NP_001315428.1	MH1_SMAD_1_5_9	13..136	CDD:199814	64/123 (52%)
		MH2_SMAD_1_5_9	266..466	CDD:199822	97/225 (43%)